P0C627
Gene name |
Ubxn2b |
Protein name |
UBX domain-containing protein 2B |
Names |
NSFL1 cofactor p37, p97 cofactor p37 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:312965 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0C627
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0C627-F1 | Predicted | AlphaFoldDB |
No variants for P0C627
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0C627 | |||||
No associated diseases with P0C627
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spindle pole centrosome | A centrosome from which one pole of a mitotic or meiotic spindle is organized. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome assembly | The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. |
| establishment of mitotic spindle orientation | A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. |
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| membrane fusion | The membrane organization process that joins two lipid bilayers to form a single membrane. |
| negative regulation of protein localization to centrosome | Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome. |
| nuclear membrane reassembly | The reformation of the nuclear membranes following their breakdown in the context of a normal process. |
| positive regulation of mitotic centrosome separation | Any process that activates or increases the frequency, rate or extent of centrosome separation. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SZC4 | NSFL1C | NSFL1 cofactor p47 | Bos taurus (Bovine) | PR |
| Q5ZK10 | NSFL1C | NSFL1 cofactor p47 | Gallus gallus (Chicken) | PR |
| Q5T124 | UBXN11 | UBX domain-containing protein 11 | Homo sapiens (Human) | PR |
| Q9UNZ2 | NSFL1C | NSFL1 cofactor p47 | Homo sapiens (Human) | PR |
| Q14CS0 | UBXN2B | UBX domain-containing protein 2B | Homo sapiens (Human) | PR |
| Q9D572 | Ubxn11 | UBX domain-containing protein 11 | Mus musculus (Mouse) | PR |
| Q99KJ0 | Ubxn2a | UBX domain-containing protein 2A | Mus musculus (Mouse) | PR |
| Q9CZ44 | Nsfl1c | NSFL1 cofactor p47 | Mus musculus (Mouse) | PR |
| Q0KL01 | Ubxn2b | UBX domain-containing protein 2B | Mus musculus (Mouse) | PR |
| O35987 | Nsfl1c | NSFL1 cofactor p47 | Rattus norvegicus (Rat) | PR |
| Q8R512 | Ubxn11 | UBX domain-containing protein 11 | Rattus norvegicus (Rat) | PR |
| F4IXN6 | PUX6 | Plant UBX domain-containing protein 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEGGGAEPE | EQERRSSRPR | PPSARDLQLA | LAELYEDEMK | CKSSKPDRST | ATAFKSPRTP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PLRLYSGDQE | YGGLHIAQPP | TGKIVNELFK | EAREHGAVPL | NEATRSSSDD | KAKSFTGGGY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLGSSFYKRS | EYIYGENQLQ | DVQILLRLWS | NGFSLDDGEL | RPYSDPTNAQ | FLESVKRGEI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLELQRLVHG | SQVSLDMEDH | QDQEYIKPRL | RFKAFSGEGQ | KLGSLTPEIV | STPSSPEEED |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSILNAAVLI | DDSVPTTKIQ | IRLADGSRLI | QRFNSTHRIL | DVRDFIVQSR | PEFATTDFIL |
| 310 | 320 | 330 | |||
| VTSFPSKELT | DESVTLQDAD | ILNTVILQQL | K |