AiPD: Autoinhibited Protein Database

Gene name	Ubxn2b
Protein name	UBX domain-containing protein 2B
Names	NSFL1 cofactor p37, p97 cofactor p37
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:68053
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-281 (Predicted disordered autoinhibitory region) PR

1-281 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q0KL01-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388671738	37	D>G	No	EVA
rs212080445	53	T>A	No	EVA
rs3388659174	59	T>I	No	EVA
rs3388672937	123	G>R	No	EVA
rs232265510	150	R>S	No	EVA
rs27694152	164	S>N	No	EVA
rs251829532	184	L>F	No	EVA
rs244918482	191	A>G	No	EVA
rs3393660925	192	Q>R	No	EVA
rs3388675118	195	L>Q	No	EVA
rs3388672377	196	D>V	No	EVA
rs3388675696	215	F>Y	No	EVA
rs27694129	246	A>T	No	EVA
rs3411829525	250	I>V	No	EVA
rs3388672942	266	G>R	No	EVA
rs3388651265	276	T>R	No	EVA
rs212699076	288	R>Q	No	EVA
rs3388669662	292	E>D	No	EVA
rs3388666845	298	F>Y	No	EVA
rs3388669222	300	L>F	No	EVA
rs27694122	313	T>S	No	EVA

Type	Name	Position	InterPro Accession
domain	UBX domain	251 - 330	IPR001012
domain	SEP domain	138 - 232	IPR012989

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm, cytosol Endoplasmic reticulum Golgi apparatus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	Localizes to centrosome during mitotic prophase and metaphase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle pole centrosome	A centrosome from which one pole of a mitotic or meiotic spindle is organized.

Name	Definition
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

Name	Definition
autophagosome assembly	The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
establishment of mitotic spindle orientation	A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
membrane fusion	The membrane organization process that joins two lipid bilayers to form a single membrane.
negative regulation of protein localization to centrosome	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome.
nuclear membrane reassembly	The reformation of the nuclear membranes following their breakdown in the context of a normal process.
positive regulation of mitotic centrosome separation	Any process that activates or increases the frequency, rate or extent of centrosome separation.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3SZC4	NSFL1C	NSFL1 cofactor p47	Bos taurus (Bovine)	PR
Q5ZK10	NSFL1C	NSFL1 cofactor p47	Gallus gallus (Chicken)	PR
Q5T124	UBXN11	UBX domain-containing protein 11	Homo sapiens (Human)	PR
Q9UNZ2	NSFL1C	NSFL1 cofactor p47	Homo sapiens (Human)	PR
Q14CS0	UBXN2B	UBX domain-containing protein 2B	Homo sapiens (Human)	PR
Q99KJ0	Ubxn2a	UBX domain-containing protein 2A	Mus musculus (Mouse)	PR
Q9CZ44	Nsfl1c	NSFL1 cofactor p47	Mus musculus (Mouse)	PR
Q9D572	Ubxn11	UBX domain-containing protein 11	Mus musculus (Mouse)	PR
O35987	Nsfl1c	NSFL1 cofactor p47	Rattus norvegicus (Rat)	PR
Q8R512	Ubxn11	UBX domain-containing protein 11	Rattus norvegicus (Rat)	PR
P0C627	Ubxn2b	UBX domain-containing protein 2B	Rattus norvegicus (Rat)	PR
F4IXN6	PUX6	Plant UBX domain-containing protein 6	Arabidopsis thaliana (Mouse-ear cress)	PR