AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

17-322 (Predicted disordered autoinhibitory region) PR

17-322 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3SZC4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs799207850	4	E>G	No	EVA
rs441314114	7	D>G	No	EVA
rs471107650	7	D>H	No	EVA
rs474809592	8	A>G	No	EVA
rs459513270	8	A>P	No	EVA
rs441932083	11	E>G	No	EVA
rs463699379	12	F>V	No	EVA
rs481795608	13	V>G	No	EVA
rs445627517	15	V>G	No	EVA
rs457759595	16	T>P	No	EVA
rs466159917	20	E>G	No	EVA
rs481460477	21	D>G	No	EVA
rs448691441	23	A>G	No	EVA
rs470336555	24	R>P	No	EVA
rs452385947	26	F>L	No	EVA
rs464586671	27	L>M	No	EVA
rs434832554	28	E>V	No	EVA
rs453470665	29	S>A	No	EVA
rs453470665	29	S>T	No	EVA
rs441868960	33	D>G	No	EVA
rs457213099	34	L>P	No	EVA
rs475676100	35	Q>H	No	EVA
rs456016288	47	D>V	No	EVA
rs210494282	86	E>K	No	EVA
rs435695345	88	E>*	No	EVA
rs467997833	149	P>T	No	EVA
rs432384182	171	E>K	No	EVA
rs453993375	174	R>G	No	EVA
rs472650493	179	D>E	No	EVA
rs433391323	287	I>N	No	EVA
rs451937721	288	S>*	No	EVA
rs474266185	303	A>D	No	EVA
rs463360171	303	A>S	No	EVA
rs456504942	304	D>G	No	EVA
rs438528040	306	G>A	No	EVA
rs460377991	307	R>G	No	EVA
rs442749345	308	L>R	No	EVA
rs478906434	308	L>V	No	EVA
rs460897690	309	V>G	No	EVA
rs482640700	310	Q>E	No	EVA
rs449787864	310	Q>R	No	EVA
rs465027761	311	K>R	No	EVA
rs477120455	312	F>V	No	EVA
rs460011543	314	H>P	No	EVA
rs445343002	314	H>Q	No	EVA
rs467200918	316	H>P	No	EVA
rs452666393	319	S>R	No	EVA
rs471219832	324	F>L	No	EVA
rs460035618	332	M>L	No	EVA
rs442013883	335	T>N	No	EVA
rs481733165	335	T>P	No	EVA
rs463758511	336	S>G	No	EVA
rs482278689	342	T>S	No	EVA
rs446203746	343	F>S	No	EVA
rs457941828	345	N>I	No	EVA

Type	Name	Position	InterPro Accession
domain	UBX domain	287 - 369	IPR001012
domain	SEP domain	176 - 270	IPR012989

		Description
EC Number
Subcellular Localization	Nucleus Golgi apparatus, Golgi stack Chromosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	Predominantly nuclear in interphase cells Bound to the axial elements of sex chromosomes in pachytene spermatocytes A small proportion of the protein is cytoplasmic, associated with Golgi stacks Localizes to centrosome during mitotic prophase and metaphase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi stack	The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
microtubule organizing center	An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
lipid binding	Binding to a lipid.
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

Name	Definition
autophagosome assembly	The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
establishment of mitotic spindle orientation	A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
membrane fusion	The membrane organization process that joins two lipid bilayers to form a single membrane.
negative regulation of protein localization to centrosome	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome.
nuclear membrane reassembly	The reformation of the nuclear membranes following their breakdown in the context of a normal process.
positive regulation of mitotic centrosome separation	Any process that activates or increases the frequency, rate or extent of centrosome separation.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZK10	NSFL1C	NSFL1 cofactor p47	Gallus gallus (Chicken)	PR
Q5T124	UBXN11	UBX domain-containing protein 11	Homo sapiens (Human)	PR
Q14CS0	UBXN2B	UBX domain-containing protein 2B	Homo sapiens (Human)	PR
Q9UNZ2	NSFL1C	NSFL1 cofactor p47	Homo sapiens (Human)	PR
Q9D572	Ubxn11	UBX domain-containing protein 11	Mus musculus (Mouse)	PR
Q99KJ0	Ubxn2a	UBX domain-containing protein 2A	Mus musculus (Mouse)	PR
Q0KL01	Ubxn2b	UBX domain-containing protein 2B	Mus musculus (Mouse)	PR
Q9CZ44	Nsfl1c	NSFL1 cofactor p47	Mus musculus (Mouse)	PR
Q8R512	Ubxn11	UBX domain-containing protein 11	Rattus norvegicus (Rat)	PR
O35987	Nsfl1c	NSFL1 cofactor p47	Rattus norvegicus (Rat)	PR
P0C627	Ubxn2b	UBX domain-containing protein 2B	Rattus norvegicus (Rat)	PR
F4IXN6	PUX6	Plant UBX domain-containing protein 6	Arabidopsis thaliana (Mouse-ear cress)	PR