F4IXN6

PR
Gene name
PUX6
Protein name
Plant UBX domain-containing protein 6
Names
PUX6
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G21660
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

189-285 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F4IXN6

Entry ID Method Resolution Chain Position Source
AF-F4IXN6-F1 Predicted AlphaFoldDB

70 variants for F4IXN6

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07968777 3 V>F No 1000Genomes
ENSVATH05879372 4 N>D No 1000Genomes
ENSVATH05879371 6 P>A No 1000Genomes
tmp_3_7626632_G_A 8 T>M No 1000Genomes
ENSVATH05879370 9 T>R No 1000Genomes
tmp_3_7626511_G_A 23 P>S No 1000Genomes
tmp_3_7626484_G_T,C 32 L>I No 1000Genomes
tmp_3_7626484_G_T,C 32 L>V No 1000Genomes
ENSVATH00338563 41 P>A No 1000Genomes
ENSVATH00338562 43 L>R No 1000Genomes
tmp_3_7626447_C_T 44 R>Q No 1000Genomes
tmp_3_7626433_T_A 49 T>S No 1000Genomes
ENSVATH05879367 65 R>Q No 1000Genomes
ENSVATH05879366 73 P>S No 1000Genomes
ENSVATH05879365 79 A>T No 1000Genomes
tmp_3_7626327_G_T 84 S>Y No 1000Genomes
ENSVATH10832433 96 V>F No 1000Genomes
ENSVATH02174255 99 D>N No 1000Genomes
ENSVATH05879363 101 F>I No 1000Genomes
tmp_3_7626273_G_T 102 S>Y No 1000Genomes
ENSVATH05879362 108 D>H No 1000Genomes
ENSVATH10832432 108 D>V No 1000Genomes
tmp_3_7626243_G_C 112 A>G No 1000Genomes
ENSVATH05879361 119 E>K No 1000Genomes
ENSVATH05879360 122 R>T No 1000Genomes
tmp_3_7626015_C_T 134 M>I No 1000Genomes
tmp_3_7626008_C_G 137 E>Q No 1000Genomes
tmp_3_7625995_G_A 141 S>F No 1000Genomes
ENSVATH10832431 146 E>K No 1000Genomes
tmp_3_7625950_G_T 156 T>K No 1000Genomes
ENSVATH05879357 162 F>L No 1000Genomes
tmp_3_7625893_G_T 175 P>Q No 1000Genomes
tmp_3_7625715_C_T 191 R>H No 1000Genomes
tmp_3_7625692_G_C 199 Q>E No 1000Genomes
ENSVATH00338557 204 S>R No 1000Genomes
tmp_3_7625534_G_A 225 P>S No 1000Genomes
ENSVATH05879350 237 I>L No 1000Genomes
tmp_3_7625260_G_T 242 Q>K No 1000Genomes
ENSVATH00338556 247 L>M No 1000Genomes
ENSVATH05879347 252 D>N No 1000Genomes
ENSVATH05879346 259 Q>R No 1000Genomes
tmp_3_7625200_C_T 262 E>K No 1000Genomes
tmp_3_7625169_G_C 272 T>S No 1000Genomes
ENSVATH00338555 273 V>L No 1000Genomes
tmp_3_7625143_T_A 281 T>S No 1000Genomes
tmp_3_7625136_T_C 283 D>G No 1000Genomes
ENSVATH00338554 284 D>Y No 1000Genomes
tmp_3_7625127_G_A 286 P>L No 1000Genomes
tmp_3_7625118_C_T 289 S>N No 1000Genomes
ENSVATH10832362 302 M>I No 1000Genomes
ENSVATH00338553 307 K>T No 1000Genomes
tmp_3_7624964_G_A 312 T>M No 1000Genomes
ENSVATH02174252 340 P>L No 1000Genomes
ENSVATH05879341 346 Q>* No 1000Genomes
tmp_3_7624743_C_T 354 V>M No 1000Genomes
ENSVATH10832361 363 S>* No 1000Genomes
ENSVATH10832360 365 Q>P No 1000Genomes
ENSVATH00338552 375 V>D No 1000Genomes
ENSVATH05879339 388 R>* No 1000Genomes
ENSVATH05879338 388 R>P No 1000Genomes
tmp_3_7624603_T_A 400 K>N No 1000Genomes
tmp_3_7624598_TAGTCTTTGG_CAGTCTTTGG,T 402 Y>C No 1000Genomes
ENSVATH05879337 403 Q>E No 1000Genomes
ENSVATH10832358 407 M>T No 1000Genomes
tmp_3_7624571_G_A 411 P>L No 1000Genomes
ENSVATH00338550 414 L>V No 1000Genomes
ENSVATH05879336 424 A>P No 1000Genomes
ENSVATH05879336 424 A>S No 1000Genomes
ENSVATH10832357 430 V>F No 1000Genomes
ENSVATH00338549 434 K>N No 1000Genomes

No associated diseases with F4IXN6

3 regional properties for F4IXN6

Type Name Position InterPro Accession
domain UBX domain 357 - 434 IPR001012
domain SEP domain 146 - 222 IPR012989-1
domain SEP domain 264 - 352 IPR012989-2

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

5 GO annotations of biological process

Name Definition
autophagosome assembly The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
membrane fusion The membrane organization process that joins two lipid bilayers to form a single membrane.
nuclear membrane reassembly The reformation of the nuclear membranes following their breakdown in the context of a normal process.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZC4 NSFL1C NSFL1 cofactor p47 Bos taurus (Bovine) PR
Q5ZK10 NSFL1C NSFL1 cofactor p47 Gallus gallus (Chicken) PR
Q5T124 UBXN11 UBX domain-containing protein 11 Homo sapiens (Human) PR
Q14CS0 UBXN2B UBX domain-containing protein 2B Homo sapiens (Human) PR
Q9UNZ2 NSFL1C NSFL1 cofactor p47 Homo sapiens (Human) PR
Q9D572 Ubxn11 UBX domain-containing protein 11 Mus musculus (Mouse) PR
Q0KL01 Ubxn2b UBX domain-containing protein 2B Mus musculus (Mouse) PR
Q99KJ0 Ubxn2a UBX domain-containing protein 2A Mus musculus (Mouse) PR
Q9CZ44 Nsfl1c NSFL1 cofactor p47 Mus musculus (Mouse) PR
Q8R512 Ubxn11 UBX domain-containing protein 11 Rattus norvegicus (Rat) PR
O35987 Nsfl1c NSFL1 cofactor p47 Rattus norvegicus (Rat) PR
P0C627 Ubxn2b UBX domain-containing protein 2B Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDVNSPETTE KHLNEVSADA AKPNVPNPND ELLRRNPSSF PNLRIKIPTS SFSTFDGSSG
70 80 90 100 110 120
YSPSRLQLRP PWPSLKRAAA NPFSRQNKRR QGAGNVRIDD FSGGTGSDSD EAVEHYGGEE
130 140 150 160 170 180
NRAIERPEQS SRSMSEETVS SELEEEPQKV FTHTVTSWSN GFTVDDSSLK TLDDPENATF
190 200 210 220 230 240
LEIISSMESP RELGQVRVQV KIISREEENY TESQAGSDSA STKPPPALAM RAKESAIERS
250 260 270 280 290 300
EQSSKVLSGE TDSAELQEQQ QEDQPYEVVT YTVTIWRNGF TVDDDPFKSL DDPENAAFLE
310 320 330 340 350 360
YMPEDNKFGV PTTTRSTSCS SQTHQELQTL AGSESTSTEP PLTTTQPPSM SSLVVDPAAP
370 380 390 400 410 420
TTSIQLILAD STRIVTQFNT HHTIRDIRCF IDTSRPDGSK DYQLLIMGSP PTPLSDFDQT
430
IEKAGIANSV LVQKF