Q5QNQ6
PR
Gene name |
Osbp2 |
Protein name |
Oxysterol-binding protein 2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74309 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5QNQ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5QNQ6-F1 | Predicted | AlphaFoldDB |
41 variants for Q5QNQ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs582741522 | 67 | K>E | No | EVA | |
| rs3389140515 | 81 | E>D | No | EVA | |
| rs582159949 | 125 | A>P | No | EVA | |
| rs217864118 | 168 | S>L | No | EVA | |
| rs3389127037 | 186 | L>F | No | EVA | |
| rs3389150238 | 242 | L>I | No | EVA | |
| rs3389103749 | 303 | T>S | No | EVA | |
| rs3389077382 | 309 | L>Q | No | EVA | |
| rs3389136625 | 313 | D>A | No | EVA | |
| rs3389103721 | 320 | L>P | No | EVA | |
| rs3389136651 | 323 | K>* | No | EVA | |
| rs3389137844 | 327 | A>T | No | EVA | |
| rs3389144501 | 333 | N>H | No | EVA | |
| rs3389140477 | 346 | E>K | No | EVA | |
| rs3389140290 | 377 | E>D | No | EVA | |
| rs3389103713 | 406 | K>* | No | EVA | |
| rs3389148827 | 413 | R>W | No | EVA | |
| rs3389148809 | 426 | S>I | No | EVA | |
| rs3389138048 | 428 | S>C | No | EVA | |
| rs3389140461 | 433 | S>G | No | EVA | |
| rs3389138120 | 440 | E>G | No | EVA | |
| rs3389127017 | 453 | A>S | No | EVA | |
| rs222563281 | 464 | V>I | No | EVA | |
| rs3389140348 | 516 | Y>C | No | EVA | |
| rs3389148869 | 531 | E>* | No | EVA | |
| rs3389111232 | 580 | F>L | No | EVA | |
| rs3389077412 | 596 | F>I | No | EVA | |
| rs3389114051 | 653 | K>E | No | EVA | |
| rs3389140519 | 659 | P>S | No | EVA | |
| rs3389150235 | 686 | I>F | No | EVA | |
| rs3389127034 | 736 | Q>R | No | EVA | |
| rs3389140468 | 748 | D>V | No | EVA | |
| rs3389137924 | 752 | E>K | No | EVA | |
| rs3389150297 | 783 | Y>N | No | EVA | |
| rs3401695971 | 794 | Y>* | No | EVA | |
| rs3401792559 | 794 | Y>H | No | EVA | |
| rs3401942826 | 795 | F>L | No | EVA | |
| rs3389137911 | 819 | D>N | No | EVA | |
| rs3389140466 | 854 | T>M | No | EVA | |
| rs3389103767 | 868 | Y>H | No | EVA | |
| rs3389148851 | 876 | R>S | No | EVA |
No associated diseases with Q5QNQ6
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical dendrite | A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| perinuclear endoplasmic reticulum | The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cholesterol binding | Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| sterol binding | Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. |
| sterol transporter activity | Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| spermatid development | The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P22059 | OSBP | Oxysterol-binding protein 1 | Homo sapiens (Human) | PR |
| Q969R2 | OSBP2 | Oxysterol-binding protein 2 | Homo sapiens (Human) | PR |
| Q8BX94 | Osbpl2 | Oxysterol-binding protein-related protein 2 | Mus musculus (Mouse) | PR |
| B9EJ86 | Osbpl8 | Oxysterol-binding protein-related protein 8 | Mus musculus (Mouse) | PR |
| Q3B7Z2 | Osbp | Oxysterol-binding protein 1 | Mus musculus (Mouse) | PR |
| Q8S8P9 | ORP1B | Oxysterol-binding protein-related protein 1B | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SAF0 | ORP1D | Oxysterol-binding protein-related protein 1D | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8L751 | ORP1C | Oxysterol-binding protein-related protein 1C | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKAAALSRG | GGCAGRSRGL | SSLFTVVPCL | SCHTAAPGMN | SSAFGSGPAS | KPQLQPVQAP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ERELLSKQVC | QPISEPASRS | EPGSQTTSVP | RPSGVGQESE | LQGLWPGSEN | GTRSVSIIKA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPELAMPSPL | QSTVGSLPVT | KPESKLVPKT | QSFLRQGQAK | ISVGTPVSGI | GVQMVSPPLD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SYKGWLLKWT | NYLKGYQRRW | FVLGNGLLSY | YRNQGEMAHT | CRATINLAST | HFETEDSCGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLCNGARTYH | LKASSEVDRQ | HWITALELAK | AKAIRVMKTQ | SDDSGDDDEE | PAAPADNSEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HHTLKTLSLK | LNDLSTCNDL | IAKHGAALQR | SLNELDSLKI | PSECGEKLKV | VNERATLFRI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TSNAMINACR | DFLELAETHS | RKWQRALNYE | QEQRVHLEET | IEQLAKQHNS | LERAFCNTPG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GPASSSKSFS | EGSFLTSKGE | NSEEDEDTEY | FDAMEDSTSF | ITVVTEAKED | RKPESGPGTT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TVDWTSADNV | LDGASFMPKN | SCKVKRRVRI | PDKPNYSLNL | WSIMKNCIGR | ELSRIPMPVN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FNEPLSMLQR | LTEDLEYHHL | LDKAVNCTSS | VEQMCLVAAF | SVSSYSTTVH | RIAKPFNPML |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GETFELDRME | DMGLRSLCEQ | VSHHPPSAAH | HVFSKHGWSL | WQEITIASKF | RGKYISIMPL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GAIHLEFQAS | GNHYVWRKST | STVHNIIVGK | LWIDQSGDIE | IVNHKTKDRC | QLKFVPYSYF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SKEAARKVTG | VVSDSQGKAH | YVLSGSWDDQ | MECSKIVHSS | PSSDGRQKTV | YQTLPAKLLW |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RKYPLPENAE | NMYYFSELAL | TLNEQEDGVA | PTDSRLRPDQ | RLMERGRWDE | ANTEKQRLEE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KQRLSRRRRL | ESCTAGCGGE | EEKESDGYVP | LWFEKRLDPL | TGEMACMYKG | GYWEAKEKKD |
| WHMCPNIF |