Q8L751
PR
Gene name |
ORP1C (At4g08180, T12G13.20) |
Protein name |
Oxysterol-binding protein-related protein 1C |
Names |
OSBP-related protein 1C |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G08180 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8L751
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8L751-F1 | Predicted | AlphaFoldDB |
64 variants for Q8L751
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_5169798_A_C | 24 | Q>H | No | 1000Genomes | |
| ENSVATH06562228 | 25 | P>S | No | 1000Genomes | |
| ENSVATH06562229 | 31 | A>S | No | 1000Genomes | |
| ENSVATH06562229 | 31 | A>T | No | 1000Genomes | |
| tmp_4_5169821_C_T | 32 | A>V | No | 1000Genomes | |
| tmp_4_5169829_G_T | 35 | G>C | No | 1000Genomes | |
| ENSVATH00477260 | 51 | Y>C | No | 1000Genomes | |
|
ENSVATH06562231 tmp_4_5169895_T_C |
57 | F>L | No | 1000Genomes | |
| ENSVATH06562232 | 64 | S>I | No | 1000Genomes | |
| ENSVATH00477261 | 76 | D>N | No | 1000Genomes | |
| ENSVATH06562234 | 88 | A>V | No | 1000Genomes | |
| tmp_4_5170045_G_A | 107 | A>T | No | 1000Genomes | |
| ENSVATH14075910 | 141 | D>Y | No | 1000Genomes | |
| tmp_4_5170211_G_A | 162 | R>H | No | 1000Genomes | |
| ENSVATH00477263 | 168 | N>H | No | 1000Genomes | |
| tmp_4_5170259_A_C | 178 | Q>P | No | 1000Genomes | |
| tmp_4_5170403_G_A | 197 | S>N | No | 1000Genomes | |
| ENSVATH00477264 | 219 | T>M | No | 1000Genomes | |
| ENSVATH06562238 | 256 | T>M | No | 1000Genomes | |
| ENSVATH00477265 | 259 | I>L | No | 1000Genomes | |
| tmp_4_5171085_T_C | 331 | C>R | No | 1000Genomes | |
| ENSVATH06562247 | 333 | G>A | No | 1000Genomes | |
| tmp_4_5171091_G_T | 333 | G>C | No | 1000Genomes | |
| tmp_4_5171100_A_G | 336 | R>G | No | 1000Genomes | |
| tmp_4_5171101_G_A | 336 | R>K | No | 1000Genomes | |
| tmp_4_5171105_C_T,A | 337 | H>Q | No | 1000Genomes | |
| tmp_4_5171310_T_C | 369 | F>L | No | 1000Genomes | |
| ENSVATH06562251 | 396 | D>N | No | 1000Genomes | |
| ENSVATH14075946 | 397 | E>D | No | 1000Genomes | |
| ENSVATH06562252 | 402 | S>F | No | 1000Genomes | |
| ENSVATH06562252 | 402 | S>Y | No | 1000Genomes | |
| ENSVATH00477272 | 404 | D>E | No | 1000Genomes | |
| ENSVATH06562253 | 405 | D>G | No | 1000Genomes | |
| tmp_4_5171450_C_G | 415 | C>W | No | 1000Genomes | |
| tmp_4_5171461_G_A | 419 | R>H | No | 1000Genomes | |
| tmp_4_5171468_A_T | 421 | K>N | No | 1000Genomes | |
| tmp_4_5171473_G_C | 423 | R>T | No | 1000Genomes | |
| ENSVATH02737397 | 428 | D>E | No | 1000Genomes | |
| tmp_4_5171604_C_G | 467 | Q>E | No | 1000Genomes | |
| ENSVATH06562256 | 482 | A>S | No | 1000Genomes | |
| tmp_4_5171658_T_A | 485 | Y>N | No | 1000Genomes | |
| tmp_4_5171794_G_A | 503 | V>I | No | 1000Genomes | |
| ENSVATH11244865 | 528 | D>N | No | 1000Genomes | |
| ENSVATH00477275 | 595 | S>C | No | 1000Genomes | |
| ENSVATH06562262 | 622 | S>G | No | 1000Genomes | |
| ENSVATH06562262 | 622 | S>R | No | 1000Genomes | |
| ENSVATH00477276 | 650 | N>D | No | 1000Genomes | |
| ENSVATH00477277 | 667 | I>M | No | 1000Genomes | |
| tmp_4_5172781_A_T | 684 | M>L | No | 1000Genomes | |
| tmp_4_5172821_C_T | 697 | P>L | No | 1000Genomes | |
| tmp_4_5172829_G_C | 700 | A>P | No | 1000Genomes | |
| ENSVATH06562264 | 716 | T>A | No | 1000Genomes | |
| ENSVATH06562265 | 719 | L>F | No | 1000Genomes | |
| tmp_4_5172979_G_C | 722 | R>T | No | 1000Genomes | |
| ENSVATH02737417 | 739 | N>K | No | 1000Genomes | |
| tmp_4_5173044_A_T | 744 | M>L | No | 1000Genomes | |
| tmp_4_5173087_A_T | 758 | Q>L | No | 1000Genomes | |
| ENSVATH02737419 | 773 | M>K | No | 1000Genomes | |
| tmp_4_5173243_A_T | 776 | K>N | No | 1000Genomes | |
| tmp_4_5173242_A_C | 776 | K>T | No | 1000Genomes | |
| ENSVATH02737421 | 792 | E>A | No | 1000Genomes | |
| tmp_4_5173304_G_A | 797 | V>I | No | 1000Genomes | |
| tmp_4_5173334_G_C | 807 | D>H | No | 1000Genomes | |
| tmp_4_5173351_G_A | 812 | M>I | No | 1000Genomes |
No associated diseases with Q8L751
11 regional properties for Q8L751
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Hemopexin-like domain | 288 - 475 | IPR000585 |
| domain | Peptidase M10, metallopeptidase | 106 - 262 | IPR001818 |
| domain | Peptidoglycan binding-like | 27 - 85 | IPR002477 |
| domain | Peptidase, metallopeptidase | 103 - 263 | IPR006026 |
| conserved_site | Hemopexin, conserved site | 327 - 342 | IPR018486 |
| repeat | Hemopexin-like repeats | 285 - 336 | IPR018487-1 |
| repeat | Hemopexin-like repeats | 335 - 381 | IPR018487-2 |
| repeat | Hemopexin-like repeats | 383 - 433 | IPR018487-3 |
| repeat | Hemopexin-like repeats | 432 - 475 | IPR018487-4 |
| binding_site | Peptidase M10A, cysteine switch, zinc binding site | 88 - 95 | IPR021158 |
| domain | Peptidase M10A, catalytic domain | 106 - 262 | IPR033739 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| sterol binding | Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. |
| sterol transporter activity | Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P22059 | OSBP | Oxysterol-binding protein 1 | Homo sapiens (Human) | PR |
| Q969R2 | OSBP2 | Oxysterol-binding protein 2 | Homo sapiens (Human) | PR |
| Q3B7Z2 | Osbp | Oxysterol-binding protein 1 | Mus musculus (Mouse) | PR |
| Q5QNQ6 | Osbp2 | Oxysterol-binding protein 2 | Mus musculus (Mouse) | PR |
| Q8S8P9 | ORP1B | Oxysterol-binding protein-related protein 1B | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SAF0 | ORP1D | Oxysterol-binding protein-related protein 1D | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHPFCCVTTV | SDHSPSMPPL | PEPQPPLPNY | AADFGSARSE | PIITRSASQS | YNHSGQFNNN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIHSLSFNHH | QSDVTDRLGQ | RVLALPAAVR | EPPVDVKIND | IVGNGIAGIL | YKWVNYGRGW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RPRWFVLQDG | VLSYYKIHGP | DKIFVSPETE | KGSKVIGDES | ARMISRHNRR | GGSSSSCQLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RKPFGEVHLK | VSSVRESRSD | DKRFSIFTGT | KRLHLRAETR | EDRTTWVEAL | QAVKDMFPRM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SNSELMAPTN | NLAMSTEKIR | LRLIEEGVSE | LAIQDCEQIM | KSEFSALQSQ | LVLLKQKQWL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LIDTLRQLET | EKVDLENTVV | DESQRQADNG | CSGELRHEKF | SEGTATESDD | DNERGDAAEE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EFDEEENTFF | DTRDFLSSSS | FKSSGSGFRT | SSFSSDEDGF | ESEDDIDPSI | KSIGCNYPRV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KRRKNLPDPV | EKEKSVSLWS | MIKDNIGKDL | TKVCLPVYFN | EPLSSLQKCF | EDLEYSYLLD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RAFEYGKRGN | SLMRILNVAA | FAVSGYASTE | GRICKPFNPL | LGETYEADYP | DKGLRFFSEK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VSHHPMVVAC | HCDGTGWKFW | GDSNLRSKFW | GRSIQLDPVG | VLTLQFDDGE | ILQWSKVTTS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IYNLILGKLY | CDHYGTMRIE | GSAEYSCKLK | FKEQSIIDRN | PHQVHGIVQN | KSGKTVATMF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GKWDESIHFV | TGDCSGKGKL | SEDMSGAQLL | WKRSKPPGNA | TKYNLTRFAI | TLNELTPGLK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ERLPPTDSRL | RPDQRYLENG | EFEMANTEKL | RLEQRQRQAR | KMQERGWKPR | WFMKEKGSES |
| 790 | 800 | 810 | |||
| YRYKGGYWEA | REDGSWVDCP | DIFGHIDSDQ | QMIE |