Q3B7Z2

PR
Gene name
Osbp (Kiaa4220)
Protein name
Oxysterol-binding protein 1
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:76303
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3B7Z2

Entry ID Method Resolution Chain Position Source
AF-Q3B7Z2-F1 Predicted AlphaFoldDB

27 variants for Q3B7Z2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs6343747 43 P>S No EVA
rs6343747 43 P>T No EVA
rs228185369 52 T>A No EVA
rs3389522582 188 S>* No EVA
rs3409346073 239 E>D No EVA
rs3412866943 278 L>I No EVA
rs255915497 329 N>D No EVA
rs3389528658 350 D>N No EVA
rs3389493551 392 Y>* No EVA
rs3389476278 392 Y>F No EVA
rs3389521119 435 P>Q No EVA
rs3389523083 482 Y>C No EVA
rs3389485381 483 S>P No EVA
rs3389528635 490 S>T No EVA
rs3389508732 500 T>I No EVA
rs3389476257 515 C>Y No EVA
rs3389540012 565 H>Q No EVA
rs3408268792 580 V>G No EVA
rs3389485348 585 V>L No EVA
rs3389436675 665 R>L No EVA
rs238616994 668 G>A No EVA
rs3389508721 671 A>P No EVA
rs3389436662 703 A>V No EVA
rs3389493572 722 M>K No EVA
rs3412978444 741 Q>* No EVA
rs3389436708 742 R>L No EVA
rs3408951766 756 T>A No EVA

No associated diseases with Q3B7Z2

2 regional properties for Q3B7Z2

Type Name Position InterPro Accession
domain Pleckstrin homology domain 86 - 181 IPR001849
conserved_site Oxysterol-binding protein, conserved site 516 - 526 IPR018494

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Cytoplasm, perinuclear region
  • Golgi apparatus membrane ; Peripheral membrane protein
  • Endoplasmic reticulum membrane ; Peripheral membrane protein
  • Predominantly cytosolic
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

14 GO annotations of cellular component

Name Definition
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
perinuclear endoplasmic reticulum The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

5 GO annotations of molecular function

Name Definition
phosphatidylinositol-4-phosphate binding Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
protein domain specific binding Binding to a specific domain of a protein.
sterol binding Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.
sterol transfer activity Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
sterol transporter activity Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

8 GO annotations of biological process

Name Definition
ceramide transport The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.
intracellular cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
phospholipid transport The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
positive regulation of insulin secretion involved in cellular response to glucose stimulus Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
positive regulation of secretory granule organization Any process that activates or increases the frequency, rate or extent of secretory granule organization.
positive regulation of tyrosine phosphorylation of STAT protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
sphingomyelin biosynthetic process The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
sterol transport The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q969R2 OSBP2 Oxysterol-binding protein 2 Homo sapiens (Human) PR
P22059 OSBP Oxysterol-binding protein 1 Homo sapiens (Human) PR
B9EJ86 Osbpl8 Oxysterol-binding protein-related protein 8 Mus musculus (Mouse) PR
Q5QNQ6 Osbp2 Oxysterol-binding protein 2 Mus musculus (Mouse) PR
Q8BX94 Osbpl2 Oxysterol-binding protein-related protein 2 Mus musculus (Mouse) PR
Q8S8P9 ORP1B Oxysterol-binding protein-related protein 1B Arabidopsis thaliana (Mouse-ear cress) PR
Q9SAF0 ORP1D Oxysterol-binding protein-related protein 1D Arabidopsis thaliana (Mouse-ear cress) PR
Q8L751 ORP1C Oxysterol-binding protein-related protein 1C Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAATELRGVV GPGPAAIAAP GGGGAGPPAV GGGGGRGDAG PGPGVAAATA ATAGGPGPGA
70 80 90 100 110 120
GGVAAGGPGS APPAAGSGGS GAGGSGSARE GWLFKWTNYI KGYQRRWFVL SNGLLSYYRS
130 140 150 160 170 180
KAEMRHTCRG TINLATANIT VEDSCNFIIS NGGAQTYHLK ASSEVERQRW VTALELAKAK
190 200 210 220 230 240
AVKMLAESDD SGDEESVSQT DKTELQSTLR TLSSKVEDLS TCNDLIAKHG TALQRSLSEL
250 260 270 280 290 300
ESLKLPAESN EKIKQVNERA TLFRITSNAM INACRDFLML AQTHSKKWQK SLQYERDQRI
310 320 330 340 350 360
RLEETLEQLA KQHNHLERAF RGATVLPANP PGSAGSGKDQ CCSGKGDMSD EDDENEFFDA
370 380 390 400 410 420
PEIITMPENL GHKRTGSNIS GASSDVSLDE QYKHQLEETK KEKRTRIPYK PNYSLNLWSI
430 440 450 460 470 480
MKNCIGKELS KIPMPVNFNE PLSMLQRLTE DLEYHELLDR AAKCENSLEQ LCYVAAFTVS
490 500 510 520 530 540
SYSTTVFRTS KPFNPLLGET FELDRLEENG YRSICEQVSH HPPAAAHHAE SKNGWTLRQE
550 560 570 580 590 600
IKITSKFRGK YLSIMPLGTI HCIFHSTGHH YTWKKVTTTV HNIIVGKLWI DQSGEIDIVN
610 620 630 640 650 660
HKTGDKCNLK FVPYSYFSRD VARKVTGEVT DPSGKVHFAL LGTWDEKMDC FKVQAASGEN
670 680 690 700 710 720
GGDARQRGHE AEDSRVMLWK RNPLPKNAEN MYYFSELALT LNAWEGGTAP TDSRLRPDQR
730 740 750 760 770 780
LMENGRWDEA NAEKQRLEEK QRLSRKKREA EAAKATEDGT PHDPYKALWF ERKKDPVTRE
790 800
LTHIYSGEYW ECKEKQDWGS CPDIF