AiPD: Autoinhibited Protein Database

Gene name	Osbpl2
Protein name	Oxysterol-binding protein-related protein 2
Names	ORP-2, OSBP-related protein 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:228983
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-166 (Predicted disordered autoinhibitory region) PR

1-166 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BX94-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388618381	2	N>H	No	EVA
rs3388615212	14	F>L	No	EVA
rs3388614380	14	F>Y	No	EVA
rs47839858	21	I>T	No	EVA
rs27694430	49	E>D	No	EVA
rs255592831	75	S>T	No	EVA
rs3388620818	81	K>N	No	EVA
rs27694384	137	A>S	No	EVA
rs3388618243	199	S>Y	No	EVA
rs3388615293	221	L>Q	No	EVA
rs3388615287	222	E>V	No	EVA
rs3388620827	231	T>S	No	EVA
rs3388610204	240	H>L	No	EVA
rs3388618433	259	N>H	No	EVA
rs27679344	315	E>D	No	EVA
rs3388615297	321	E>K	No	EVA
rs236627914	335	G>S	No	EVA
rs3388619928	343	V>L	No	EVA
rs3388619957	351	V>L	No	EVA
rs3392626059	409	R>H	No	EVA
rs3388615196	411	D>G	No	EVA
rs3388602846	433	K>R	No	EVA
rs3388615292	447	E>*	No	EVA
rs3388602861	482	D>A	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Oxysterol-binding protein, conserved site	174 - 184	IPR018494

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Lipid droplet Cell membrane ; Peripheral membrane protein ; Cytoplasmic side	Detected on the surface of cytosolic lipid droplets Recruited to the cell membrane by phosphatidylinositol-phosphate binding
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of cytoplasmic side of plasma membrane	The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
lipid droplet	An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

Name	Definition
cholesterol binding	Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
cholesterol transfer activity	Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
phosphatidylinositol transfer activity	Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
phosphatidylinositol-4,5-bisphosphate binding	Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
sterol binding	Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.
sterol transporter activity	Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

Name	Definition
cholesterol transport	The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
intracellular cholesterol transport	The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
phospholipid transport	The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
plasma membrane organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
protein homotetramerization	The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9H1P3	OSBPL2	Oxysterol-binding protein-related protein 2	Homo sapiens (Human)	PR
Q5QNQ6	Osbp2	Oxysterol-binding protein 2	Mus musculus (Mouse)	PR
B9EJ86	Osbpl8	Oxysterol-binding protein-related protein 8	Mus musculus (Mouse)	PR
Q3B7Z2	Osbp	Oxysterol-binding protein 1	Mus musculus (Mouse)	PR