AiPD: Autoinhibited Protein Database

P22059

Gene name	OSBP
Protein name	Oxysterol-binding protein 1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5007
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-115 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-115 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for P22059

Entry ID	Method	Resolution	Chain	Position	Source
2RR3	NMR	-	B	346-379	PDB
7V62	X-ray	325 A	A/B/C/D	406-807	PDB
AF-P22059-F1	Predicted				AlphaFoldDB

433 variants for P22059

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA380794659 rs1183694496	2	A>V		No	ClinGen gnomAD
rs1365796297 CA380794654	3	A>S		No	ClinGen TOPMed
rs1474518974 CA380794652	3	A>V		No	ClinGen gnomAD
CA223209081 rs1032971651	9	V>L		No	ClinGen TOPMed
CA223209076 rs902678365	11	G>E		No	ClinGen TOPMed gnomAD
CA380794574 rs1590682224	11	G>R		No	ClinGen Ensembl
rs1192199441 CA380794562	12	P>L		No	ClinGen gnomAD
CA223209074 rs534529690	15	A>P		No	ClinGen Ensembl
CA223209069 rs1013660475	16	A>G		No	ClinGen TOPMed
CA380794513 rs1288045626	17	I>T		No	ClinGen TOPMed gnomAD
rs1565123164 CA380794500	18	A>G		No	ClinGen Ensembl
CA380794509 rs1475957711	18	A>T		No	ClinGen TOPMed
rs1590682201 CA380794498	19	A>P		No	ClinGen Ensembl
CA380794491 rs1181729191	19	A>V		No	ClinGen TOPMed
rs1289906341 CA380794442	24	G>S		No	ClinGen gnomAD
rs1455351345 CA380794421	26	G>S		No	ClinGen TOPMed
CA380794411 rs1322169645	27	P>A		No	ClinGen TOPMed
TCGA novel	28	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA223209047 rs937972849	30	V>L		No	ClinGen TOPMed
rs1381327670 CA380794335	34	G>D		No	ClinGen TOPMed
CA380794341 rs1255747197	34	G>S		No	ClinGen gnomAD
rs568719199 CA223209045	35	G>S		No	ClinGen 1000Genomes TOPMed gnomAD
CA380794318 rs1366750243	36	R>H		No	ClinGen gnomAD
rs1038016073 CA223209042	39	A>G		No	ClinGen TOPMed gnomAD
CA380794287 rs1326512397	39	A>T		No	ClinGen gnomAD
rs1038016073 CA380794283	39	A>V		No	ClinGen TOPMed gnomAD
rs1207006009 CA380794269	40	G>A		No	ClinGen TOPMed
CA380794188 rs1447873121	47	S>L		No	ClinGen TOPMed
CA380794166 rs1209939891	49	T>K		No	ClinGen TOPMed
CA380794152 rs1474084894	51	V>I		No	ClinGen TOPMed
rs1188003281 CA380794141	52	A>T		No	ClinGen TOPMed
rs1590682136 CA380794126	53	A>S		No	ClinGen Ensembl
rs1410528214 CA380794122	53	A>V		No	ClinGen TOPMed
rs1478006296 CA380794112	54	A>V		No	ClinGen TOPMed gnomAD
CA380794103 rs1197034604	55	A>G		No	ClinGen gnomAD
rs983277231 CA223209018	58	P>A		No	ClinGen TOPMed gnomAD
CA223209015 rs933173423	60	P>L		No	ClinGen TOPMed gnomAD
rs550652114 CA6019875	62	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs550652114 CA380794041	62	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs974525360 CA223209000	63	G>V		No	ClinGen TOPMed
rs1226654072 CA380794014	64	G>V		No	ClinGen TOPMed
rs1281484762 CA380794012	65	V>M		No	ClinGen TOPMed
CA380793978 rs1319585461	68	A>S		No	ClinGen gnomAD
rs1346698077 CA380793960	70	P>L		No	ClinGen TOPMed gnomAD
CA6019874 rs770727659	71	A>V		No	ClinGen ExAC gnomAD
CA380793952 rs1440089956	72	P>S		No	ClinGen gnomAD
CA6019873 rs749016554	73	A>V		No	ClinGen ExAC gnomAD
rs773165924 CA6019872	74	P>T		No	ClinGen ExAC gnomAD
rs769818876 CA6019871	76	T>P		No	ClinGen ExAC TOPMed gnomAD
CA6019870 rs748005178	78	G>C		No	ClinGen ExAC TOPMed gnomAD
rs768604232 CA6019868	79	S>L		No	ClinGen ExAC TOPMed gnomAD
rs528977360 CA6019869	79	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA380793909 rs1231771485	80	G>D		No	ClinGen gnomAD
CA380793905 rs200837578	81	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6019866 rs200837578	81	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA380793896 rs1260943265	82	S>L		No	ClinGen gnomAD
CA6019865 rs528395741	83	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1304016193 CA380793891	83	G>V		No	ClinGen gnomAD
rs1590682039 CA380793888	84	A>S		No	ClinGen Ensembl
CA6019864 rs750765114	84	A>V		No	ClinGen ExAC
rs757826892 CA6019862	85	G>V		No	ClinGen ExAC gnomAD
CA380793878 rs1184037322	86	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1184037322 CA380793880	86	G>S		No	ClinGen TOPMed gnomAD
rs1034147270 CA223208922	87	S>L		No	ClinGen TOPMed
CA6019859 rs201962555	89	S>A		No	ClinGen 1000Genomes ExAC
rs1469079592 CA380793855	90	A>G		No	ClinGen TOPMed gnomAD
CA6019857 rs200764299	90	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA380793854 rs1469079592	90	A>V		No	ClinGen TOPMed gnomAD
CA223208911 rs866560928	91	R>L		No	ClinGen Ensembl
CA380793841 rs1194887225	93	G>S		No	ClinGen gnomAD
CA380793828 rs1177995319	94	W>C		No	ClinGen gnomAD
CA380793794 rs1417173633	99	T>A		No	ClinGen gnomAD
rs1407170785 CA380793755	104	G>D		No	ClinGen gnomAD
rs1441068824 CA380793740	106	Q>*		No	ClinGen gnomAD
CA223208902 rs374783673	106	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA380793724 rs1252590974	109	W>R		No	ClinGen gnomAD
CA6019853 TCGA novel CA380793710 rs761868177	110	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC TOPMed gnomAD
CA380793714 rs1590681975	110	F>V		No	ClinGen Ensembl
CA380793701 rs1248096653	112	L>P		No	ClinGen TOPMed
rs776371465 CA6019852	113	S>N		No	ClinGen ExAC gnomAD
CA380793687 rs1287444371	114	N>S		No	ClinGen gnomAD
rs1381637467 CA380793666	118	S>G		No	ClinGen gnomAD
rs375768205 CA6019833	121	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1590679648 CA380793570	129	T>P		No	ClinGen Ensembl
rs1590679635 CA380793544	133	T>P		No	ClinGen Ensembl
rs1590679630 CA380793527	135	N>T		No	ClinGen Ensembl
CA380793517 rs1268888381	137	A>T		No	ClinGen gnomAD
rs746162986 CA6019829	139	A>V		No	ClinGen ExAC gnomAD
CA6019828 rs376305185	140	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA380793442 rs1226924510	143	V>M		No	ClinGen gnomAD
rs373860788 CA6019826	146	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	148	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1278534804 CA380793386	150	I>L		No	ClinGen gnomAD
CA6019825 rs778367742	152	S>F		No	ClinGen ExAC gnomAD
rs1343558185 CA380793353	155	G>C		No	ClinGen gnomAD
CA223206308 rs778154083	158	T>I		No	ClinGen Ensembl
rs758027822 CA223206299	161	L>V		No	ClinGen gnomAD
rs537706135 CA380793299	163	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6019823 rs537706135	163	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757845623 CA6019821	171	R>C		No	ClinGen ExAC gnomAD
CA380793243 rs1173270765	171	R>H		No	ClinGen gnomAD
rs1173270765 CA380793244	171	R>L		No	ClinGen gnomAD
CA380793227 rs1590679573	173	V>G		No	ClinGen Ensembl
rs1479695225 CA380793221	174	T>M		No	ClinGen gnomAD
TCGA novel	180	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs924821619 CA223206285	186	M>L		No	ClinGen TOPMed
rs1458328975 CA380793137	187	L>P		No	ClinGen gnomAD
CA380793139 rs764652006	187	L>V		No	ClinGen ExAC TOPMed gnomAD
CA380793135 rs1378281093	188	A>T		No	ClinGen gnomAD
rs1455063424 CA380793119	190	S>A		No	ClinGen TOPMed
rs1455063424 CA380793121	190	S>T		No	ClinGen TOPMed
CA6019797 rs753528162	200	S>L		No	ClinGen ExAC TOPMed gnomAD
CA380792891 rs1258952741	204	K>E		No	ClinGen TOPMed gnomAD
CA380792884 rs1238764417	204	K>R		No	ClinGen TOPMed gnomAD
rs752689363 CA6019794	205	T>S		No	ClinGen ExAC gnomAD
rs568879919 CA6019793	208	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA6019790 rs766453014	212	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	212	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1335189573 CA380792774	212	R>W	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1383417980 CA380792758	213	T>I		No	ClinGen gnomAD
rs1383417980 CA380792761	213	T>N		No	ClinGen gnomAD
CA380792727 rs1420348286	216	S>C		No	ClinGen gnomAD
CA380792725 rs1382203904	216	S>N		No	ClinGen gnomAD
CA6019787 rs770147188	217	K>N		No	ClinGen ExAC gnomAD
rs773362900 CA6019788	217	K>T		No	ClinGen ExAC gnomAD
CA380792620 rs1289383818	223	T>M		No	ClinGen TOPMed
CA6019786 rs762121813	225	N>S		No	ClinGen ExAC gnomAD
rs200597145 CA6019782	231	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769090571 CA6019784	231	H>Y		No	ClinGen ExAC gnomAD
CA6019781 rs770463074	237	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs748966536 CA6019780 COSM929071	237	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs748966536 CA380792514	237	R>L		No	ClinGen ExAC gnomAD
TCGA novel	240	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6019779 rs373171037	240	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6019778 rs756005928	246	K>R		No	ClinGen ExAC gnomAD
CA380792424 rs1463324994	251	S>N		No	ClinGen Ensembl
CA6019776 rs781114937 COSM1746359	255	I>M	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
rs1027216304 CA223205091	255	I>T		No	ClinGen TOPMed gnomAD
TCGA novel	256	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA223205086 rs960677903	256	K>R		No	ClinGen TOPMed
rs751500508 CA6019774	260	E>K		No	ClinGen ExAC gnomAD
rs763023093 CA6019772	261	R>G		No	ClinGen ExAC gnomAD
CA223205076 rs1033671469	263	T>A		No	ClinGen TOPMed
CA6019765 rs776009854	267	I>K		No	ClinGen ExAC gnomAD
CA6019766 rs545855578	267	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA6019764 rs767353802	269	S>C		No	ClinGen ExAC TOPMed gnomAD
rs1157833641 CA380792299	270	N>S		No	ClinGen TOPMed gnomAD
TCGA novel	271	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761712190 CA6019762	274	N>S		No	ClinGen ExAC gnomAD
rs1276625973 CA380791616	277	R>G		No	ClinGen gnomAD
VAR_036099	278	D>A	a colorectal cancer sample; somatic mutation [UniProt]	No	UniProt
TCGA novel	278	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370601390 CA6019739	281	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs566418356 CA380791564	281	M>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs566418356 CA6019738	281	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs370601390 CA6019740	281	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs746769792 CA6019737	283	A>D		No	ClinGen ExAC TOPMed gnomAD
CA380791544 rs1339153440	283	A>T		No	ClinGen TOPMed
CA380791536 rs746769792	283	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA380791507 rs1305497015	285	T>I		No	ClinGen TOPMed
rs1336953005 CA380791497	286	H>R		No	ClinGen TOPMed
rs200496917 CA6019736	287	S>G		No	ClinGen ExAC TOPMed gnomAD
CA6019735 rs758368853	287	S>N		No	ClinGen ExAC TOPMed gnomAD
CA380791446 rs1343426450	289	K>I		No	ClinGen TOPMed gnomAD
CA6019734 rs745797894	289	K>N		No	ClinGen ExAC gnomAD
rs779020373 CA6019733	295	Q>R		No	ClinGen ExAC gnomAD
CA380791398 rs1317561583	296	Y>H		No	ClinGen gnomAD
CA6019731 rs539140126 CA6019730	299	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs532172095 CA6019728	300	Q>H		No	ClinGen ExAC gnomAD
rs764340556 CA6019729	300	Q>R		No	ClinGen ExAC gnomAD
rs753154427 CA6019727	303	R>L		No	ClinGen ExAC gnomAD
rs1590675877 CA380791291	307	T>P		No	ClinGen Ensembl
TCGA novel	312	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380791093 rs1173933535	316	N>D		No	ClinGen TOPMed gnomAD
CA380791069 rs1590675851	317	H>P		No	ClinGen Ensembl
rs1420946983 CA380791071	317	H>Y		No	ClinGen TOPMed
rs376924625 CA6019720	326	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1469004266 CA380790882	326	T>M		No	ClinGen gnomAD
CA6019718 rs141158743	329	P>L		No	ClinGen ESP ExAC gnomAD
CA380790802 rs1360040684	332	T>A		No	ClinGen TOPMed
rs1429527614 CA380790792	332	T>I		No	ClinGen gnomAD
rs778758910 CA6019715	334	G>S		No	ClinGen ExAC gnomAD
rs757362760 CA6019714	335	N>H		No	ClinGen ExAC gnomAD
rs1158741752 CA380790725	335	N>I		No	ClinGen TOPMed gnomAD
CA380790722 rs1158741752	335	N>S		No	ClinGen TOPMed gnomAD
CA6019713 rs749342934	337	G>C		No	ClinGen ExAC TOPMed gnomAD
CA223201836 rs912726234	341	D>G		No	ClinGen Ensembl
rs1218870076 CA380790029	342	Q>*		No	ClinGen TOPMed gnomAD
rs1218870076 CA380790031	342	Q>E		No	ClinGen TOPMed gnomAD
CA223201833 rs749111906	342	Q>R		No	ClinGen TOPMed
CA6019694 rs749150844	343	C>R		No	ClinGen ExAC gnomAD
CA223201816 rs564502273	344	C>W		No	ClinGen 1000Genomes TOPMed gnomAD
CA6019693 rs777977015	347	K>R		No	ClinGen ExAC TOPMed gnomAD
CA380789892 rs1264252415	349	D>E		No	ClinGen TOPMed
TCGA novel	349	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	350	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1323746866 CA380789844	352	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA380789796 rs1294829309	354	D>G		No	ClinGen gnomAD
rs1294829309 CA380789793	354	D>V		No	ClinGen gnomAD
CA380789782 rs1383985326	355	D>H		No	ClinGen TOPMed
CA6019691 rs201724760	356	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA380789767 rs1216644970	356	E>K		No	ClinGen gnomAD
TCGA novel	358	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	359	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	360	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380789646 rs1344220031	363	P>S		No	ClinGen TOPMed
rs1290300974 CA380789633	364	E>*		No	ClinGen TOPMed
CA380789627 rs1365580532	364	E>V		No	ClinGen TOPMed
CA6019690 rs781522087	366	I>M		No	ClinGen ExAC gnomAD
CA223201806 rs868209558	369	P>S		No	ClinGen Ensembl
rs146158916 CA6019689	373	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA223201800 rs746499770	374	H>L		No	ClinGen Ensembl
CA380789456 rs1292452530	375	K>R		No	ClinGen gnomAD
COSM1739798 CA6019671 rs202073964	376	R>C	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA6019670 rs142125325	376	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	378	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750942135 CA6019668	379	S>N		No	ClinGen ExAC gnomAD
rs369375135 CA380789310	380	N>I		No	ClinGen ESP TOPMed gnomAD
rs369375135 CA223201528	380	N>S		No	ClinGen ESP TOPMed gnomAD
rs1458404433 CA380789278	382	S>N		No	ClinGen gnomAD
rs1024164431 CA223201506	384	A>V		No	ClinGen TOPMed
CA6019667 rs779250604	386	S>G		No	ClinGen ExAC
rs1325918870 CA380789190	388	I>T		No	ClinGen Ensembl
CA6019665 rs752257399	390	L>F		No	ClinGen ExAC gnomAD
rs181415530 CA223201485	393	Q>E		No	ClinGen 1000Genomes
rs779315004 CA6019650	394	Y>C		No	ClinGen ExAC
rs1353953805 CA380789051	395	K>N		No	ClinGen gnomAD
CA6019649 rs200726039	395	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA380789033 rs1280976331	396	H>R		No	ClinGen gnomAD
CA223201301 rs944567129	397	Q>P		No	ClinGen TOPMed gnomAD
rs200153690 CA6019647	401	T>I		No	ClinGen ExAC TOPMed gnomAD
rs754431059 CA6019646	405	K>R		No	ClinGen ExAC TOPMed gnomAD
CA6019644 rs138158355	408	R>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs78163577 CA223201270	411	Y>*		No	ClinGen gnomAD
rs1410414498 CA380788776	411	Y>N		No	ClinGen gnomAD
rs1367616252 CA380788713	413	P>R		No	ClinGen gnomAD
rs765073139 CA6019640	418	N>H		No	ClinGen ExAC gnomAD
TCGA novel	418	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6019637 rs374348079	423	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	424	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380788270 rs1355230615	430	E>G		No	ClinGen gnomAD
rs1215214989 CA380788063	437	P>L		No	ClinGen TOPMed gnomAD
rs1215214989 CA380788065	437	P>Q		No	ClinGen TOPMed gnomAD
CA380785084 rs1237894248	439	N>K		No	ClinGen gnomAD
CA380785009 COSM689526 rs770322746	442	E>D	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1277179939 CA380784965	444	L>F		No	ClinGen gnomAD
CA380784953 rs1218687865	445	S>C		No	ClinGen gnomAD
TCGA novel	446	M>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1182201158 CA380784896	447	L>F		No	ClinGen TOPMed
rs1348629156 CA380784797	451	T>A		No	ClinGen gnomAD
TCGA novel	453	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1245963763 CA380784668	455	E>D		No	ClinGen TOPMed
rs1205391819 CA380784578	457	H>R		No	ClinGen gnomAD
CA380784503 rs1376449593	458	E>V		No	ClinGen TOPMed gnomAD
rs745510303 CA6019601	461	D>E		No	ClinGen ExAC gnomAD
rs778586297 CA6019600	462	R>*		No	ClinGen ExAC gnomAD
CA223198304 rs551492583	462	R>Q		No	ClinGen TOPMed gnomAD
CA6019599 rs757138847	465	K>N		No	ClinGen ExAC gnomAD
CA6019598 rs753738134	466	C>S		No	ClinGen ExAC gnomAD
rs777682124 CA6019597	467	E>G		No	ClinGen ExAC TOPMed gnomAD
CA223198279 rs201345633	473	L>F		No	ClinGen Ensembl
CA223198259 rs919043317	474	C>S		No	ClinGen TOPMed
rs1167414323 CA380783778	475	Y>H		No	ClinGen TOPMed
TCGA novel	477	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380783671 rs1393405258	478	A>V		No	ClinGen TOPMed
rs1209967124 CA380783594	481	V>M		No	ClinGen TOPMed gnomAD
rs1282477340 CA380783414	486	T>A		No	ClinGen gnomAD
CA380783277 COSM929065 rs1353247419	490	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1308041218 CA380783259	490	R>H		No	ClinGen gnomAD
CA380782937 rs1224102128	500	G>R		No	ClinGen gnomAD
CA380782729 RCV000736214 rs1565117343	507	R>*		No	ClinGen ClinVar Ensembl dbSNP
CA380782724 rs1245181314 COSM929064	507	R>Q	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1375206443 CA380782704	508	L>S		No	ClinGen gnomAD
rs373967138 CA223198195	510	E>A		No	ClinGen ESP TOPMed
CA223198191 rs908640685	510	E>D		No	ClinGen gnomAD
COSM1218908 rs149764564 CA6019587	514	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1314163252 CA380782427	515	S>T		No	ClinGen gnomAD
rs1221840609 CA380782326	517	C>S		No	ClinGen TOPMed gnomAD
rs758673285 CA6019573	528	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6019571 rs765590019	530	H>D		No	ClinGen ExAC gnomAD
CA6019570 rs762196934	532	E>K		No	ClinGen ExAC gnomAD
rs777025517 CA6019569	534	K>Q		No	ClinGen ExAC gnomAD
rs1462343262 CA380781622	534	K>R		No	ClinGen gnomAD
CA380781489 rs1167421043	538	T>I		No	ClinGen gnomAD
CA380781432 rs1565117241	540	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA6019567 rs761057427	540	R>H		No	ClinGen ExAC gnomAD
CA6019565 rs770551481	543	I>M		No	ClinGen ExAC gnomAD
CA6019566 rs774073983	543	I>V		No	ClinGen ExAC gnomAD
CA6019564 rs748962701	546	T>A		No	ClinGen ExAC gnomAD
rs1265134050 CA380781256	546	T>I		No	ClinGen gnomAD
TCGA novel	548	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1407629159 CA380781159	550	R>Q		No	ClinGen gnomAD
rs1212807077 CA380781108	552	K>R		No	ClinGen gnomAD
CA223197802 rs777673716	556	I>V		No	ClinGen gnomAD
rs1274836208	559	L>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	560	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380775797 rs1460606967	564	C>G		No	ClinGen TOPMed
rs372017413 CA6019550	569	T>A		No	ClinGen ESP ExAC gnomAD
TCGA novel	569	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6019548 rs776084128	571	H>Q		No	ClinGen ExAC gnomAD
CA6019549 rs148193754	571	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA380775389 rs1302094511	575	W>G		No	ClinGen gnomAD
rs1039058199 CA223189868	576	K>N		No	ClinGen TOPMed gnomAD
rs762517186 CA6019547	577	K>N		No	ClinGen ExAC gnomAD
TCGA novel	578	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380775182 rs1284628712	580	T>I		No	ClinGen TOPMed gnomAD
CA223189859 rs1049721797	589	K>R		No	ClinGen TOPMed
rs773023625 CA6019545	594	Q>E		No	ClinGen ExAC gnomAD
CA380774028 rs1256794395	597	E>G		No	ClinGen gnomAD
rs764637254 CA6019522	597	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1565113718 CA380773894	600	I>M		No	ClinGen Ensembl
rs1210953565 CA380773887	601	V>L		No	ClinGen gnomAD
rs776075863 CA6019520	602	N>T		No	ClinGen ExAC gnomAD
CA380773772 rs1204126880	603	H>Q		No	ClinGen TOPMed gnomAD
CA380773731 rs1281630531	604	K>N		No	ClinGen TOPMed gnomAD
rs1350948676 CA380773752	604	K>R		No	ClinGen gnomAD
rs546173084 CA223189103	607	D>H		No	ClinGen 1000Genomes
rs765286860 CA6019519	608	K>E		No	ClinGen ExAC gnomAD
CA380773493 rs1294480779	610	N>K		No	ClinGen gnomAD
CA380773329 rs1323946250	614	V>A		No	ClinGen TOPMed
rs1295806311 CA380773273	617	S>R		No	ClinGen gnomAD
rs1045633212 CA223189101	618	Y>C		No	ClinGen TOPMed
CA380773178 rs1417199515	623	V>I		No	ClinGen gnomAD
CA380773145 rs1242140867	624	A>V		No	ClinGen TOPMed
CA6019505 rs751950026	628	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA380796852 rs1191465717	630	E>A		No	ClinGen TOPMed
CA6019502 rs375035258	630	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA380796803 rs1393381440	633	D>E		No	ClinGen gnomAD
CA6019501 rs763784991	633	D>G		No	ClinGen ExAC TOPMed gnomAD
CA380796786 rs1165385524	634	P>S		No	ClinGen gnomAD
CA223235495 rs867902192	635	S>L		No	ClinGen Ensembl
rs775328755 CA6019499	637	K>E		No	ClinGen ExAC gnomAD
rs1269475983 CA380796712	638	V>I		No	ClinGen gnomAD
rs1166780481 CA380796651	641	A>G		No	ClinGen gnomAD
CA6019498 rs767288006	645	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1191312517 CA380796581	647	D>Y		No	ClinGen gnomAD
rs1467766752 CA380796512	650	M>I		No	ClinGen gnomAD
CA223235467 CA223235469 rs75832665	653	F>L		No	ClinGen Ensembl
CA6019496 rs774089477	656	Q>H		No	ClinGen ExAC gnomAD
rs1253953151 CA380796370	656	Q>L		No	ClinGen gnomAD
CA380796344 rs1363863199	658	V>A		No	ClinGen TOPMed
CA223235456 rs1020987135	659	I>L		No	ClinGen Ensembl
CA380796327 rs1294392978	660	G>W		No	ClinGen TOPMed
rs201177669 CA223235452	661	E>D		No	ClinGen 1000Genomes
rs183109024 CA6019495	663	G>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs183109024 CA380796293	663	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773323590 CA6019493	664	G>R		No	ClinGen ExAC TOPMed gnomAD
CA380796286 rs1341497547	664	G>V		No	ClinGen gnomAD
rs1000589949 CA223235437	670	G>C		No	ClinGen TOPMed gnomAD
rs755324935 CA6019489	672	E>D		No	ClinGen ExAC TOPMed gnomAD
rs144553266 CA6019490	672	E>G		No	ClinGen ESP ExAC gnomAD
rs1210335027 CA380796203	673	A>T		No	ClinGen gnomAD
CA380796196 rs1321039265	673	A>V		No	ClinGen gnomAD
rs1328052536 CA380796193	674	E>K		No	ClinGen gnomAD
CA380796146 rs1410488739	677	R>S		No	ClinGen gnomAD
TCGA novel	678	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs139689203 CA6019488	678	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA6019487 rs559003347	679	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	680	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	682	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758915891 CA6019486	685	P>S		No	ClinGen ExAC TOPMed gnomAD
rs758915891 CA380796075	685	P>T		No	ClinGen ExAC TOPMed gnomAD
CA380796067 rs1241192701	686	L>S		No	ClinGen TOPMed
CA6019485 rs753329392	687	P>L		No	ClinGen ExAC gnomAD
CA223235373 rs867239503	687	P>S		No	ClinGen Ensembl
CA6019466 rs777278745	688	K>R		No	ClinGen ExAC gnomAD
rs925162428 CA223234809	689	N>H		No	ClinGen TOPMed
rs1282588011 CA380796033	690	A>T		No	ClinGen gnomAD
rs1213840643 CA380796028	690	A>V		No	ClinGen gnomAD
CA380796025 rs1316562453	691	E>*		No	ClinGen gnomAD
CA380795994 rs1437710401	695	Y>H		No	ClinGen gnomAD
CA223234792 rs1043632118	697	S>L		No	ClinGen TOPMed
CA380795971 rs1352232253	698	E>K		No	ClinGen gnomAD
rs1565112858 CA380795959	700	A>S		No	ClinGen Ensembl
CA6019463 rs767109972	702	T>S		No	ClinGen ExAC gnomAD
COSM1746358 CA223234784 rs945182920	704	N>S	urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1304083176 CA380795925	705	A>V		No	ClinGen gnomAD
CA380795913 rs1565112845	707	E>K		No	ClinGen Ensembl
rs898000579 CA223234779	710	T>P		No	ClinGen Ensembl
CA6019461 rs200625839	712	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs112258923 CA223234775	713	T>A		No	ClinGen Ensembl
rs1402844425 CA380795873	713	T>I		No	ClinGen gnomAD
CA380795855 rs1416181943 COSM929060	716	R>W	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs762860195 CA6019459	718	R>*		No	ClinGen ExAC gnomAD
CA223234767 rs777564295	718	R>Q		No	ClinGen Ensembl
rs750315614 CA6019458	719	P>T		No	ClinGen ExAC gnomAD
TCGA novel	720	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1184928493 CA380795826	721	Q>E		No	ClinGen TOPMed gnomAD
TCGA novel	727	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6019457 COSM1355015 rs765435028	728	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA380795777 rs765435028	728	R>G		No	ClinGen ExAC TOPMed gnomAD
rs761932791 CA6019456	728	R>H		No	ClinGen ExAC gnomAD
CA380795767 rs1216203206	729	W>*		No	ClinGen gnomAD
TCGA novel	732	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768805720 CA6019455	734	A>V		No	ClinGen ExAC TOPMed gnomAD
CA223234730 rs931665341	738	R>C		No	ClinGen TOPMed gnomAD
rs775775277 CA6019452 COSM3383622	738	R>H	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA380795676 rs775775277	738	R>L		No	ClinGen ExAC TOPMed gnomAD
CA380795594 rs772422914	746	S>A		No	ClinGen ExAC gnomAD
CA380795588 rs1433304291	746	S>C		No	ClinGen TOPMed
rs772422914 CA6019451	746	S>P		No	ClinGen ExAC gnomAD
rs765405208 CA223234712	752	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA380795499 rs1244615136	753	E>D		No	ClinGen TOPMed
rs142554412 CA6019448	755	M>I		No	ClinGen ESP ExAC
CA6019449 rs779352340	755	M>V		No	ClinGen ExAC gnomAD
CA6019446 rs780652604	757	A>T		No	ClinGen ExAC gnomAD
rs1043034048 CA223234670	759	E>K		No	ClinGen Ensembl
CA6019444 rs529893810	759	E>V		No	ClinGen 1000Genomes ExAC gnomAD
rs779715318 CA6019443	760	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	760	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380795390 rs1259760978	761	G>S		No	ClinGen TOPMed
CA6019427 rs200097455	763	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs148420169 CA6019424	767	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA380795276 rs1333144383	768	K>E		No	ClinGen gnomAD
rs1305329785 CA380795261	769	A>S		No	ClinGen gnomAD
CA6019420 rs375857883	774	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6019421 rs778846078	774	R>W		No	ClinGen ExAC TOPMed gnomAD
rs374098760 CA6019419	778	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1396864644 CA380795147	785	H>R		No	ClinGen gnomAD
CA6019418 rs764085013	787	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	788	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380795123 rs1404584173	789	G>R		No	ClinGen gnomAD
rs559425511 CA6019416	793	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1239111627 CA380795088	793	E>G		No	ClinGen TOPMed
rs1182468515 CA380795082	794	C>Y		No	ClinGen TOPMed
rs1418420832 CA380795025	799	D>H		No	ClinGen gnomAD
rs1418420832 CA380795024	799	D>N		No	ClinGen gnomAD
CA6019414 rs759725539	801	S>T		No	ClinGen ExAC gnomAD
CA6019412 rs61755077	804	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6019409 rs202156177	805	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1018777721 CA223234530	805	D>N		No	ClinGen TOPMed
CA380794918 rs1238839857	808	F>C		No	ClinGen gnomAD
rs1259331834 CA380794924	808	F>R		No	ClinGen gnomAD

No associated diseases with P22059

2 regional properties for P22059

Type	Name	Position	InterPro Accession
domain	Pleckstrin homology domain	88 - 183	IPR001849
conserved_site	Oxysterol-binding protein, conserved site	518 - 528	IPR018494

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Cytoplasm, perinuclear region Golgi apparatus membrane; Peripheral membrane protein Endoplasmic reticulum membrane; Peripheral membrane protein Golgi apparatus, trans-Golgi network	Predominantly cytosolic
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

14 GO annotations of cellular component

Name	Definition
cell junction	A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
perinuclear endoplasmic reticulum	The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
trans-Golgi network	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

6 GO annotations of molecular function

Name	Definition
oxysterol binding	Binding to oxysterol, an oxidized form of cholesterol.
phosphatidylinositol-4-phosphate binding	Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
protein domain specific binding	Binding to a specific domain of a protein.
sterol binding	Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.
sterol transfer activity	Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
sterol transporter activity	Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

9 GO annotations of biological process

Name	Definition
bile acid biosynthetic process	The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
ceramide transport	The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.
intracellular cholesterol transport	The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
phospholipid transport	The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
positive regulation of insulin secretion involved in cellular response to glucose stimulus	Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
positive regulation of secretory granule organization	Any process that activates or increases the frequency, rate or extent of secretory granule organization.
positive regulation of tyrosine phosphorylation of STAT protein	Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
sphingomyelin biosynthetic process	The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
sterol transport	The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9BZF1	OSBPL8	Oxysterol-binding protein-related protein 8	Homo sapiens (Human)	PR
Q9H0X9	OSBPL5	Oxysterol-binding protein-related protein 5	Homo sapiens (Human)	PR
Q969R2	OSBP2	Oxysterol-binding protein 2	Homo sapiens (Human)	PR
Q9H1P3	OSBPL2	Oxysterol-binding protein-related protein 2	Homo sapiens (Human)	PR
Q5QNQ6	Osbp2	Oxysterol-binding protein 2	Mus musculus (Mouse)	PR
Q3B7Z2	Osbp	Oxysterol-binding protein 1	Mus musculus (Mouse)	PR
Q8S8P9	ORP1B	Oxysterol-binding protein-related protein 1B	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SAF0	ORP1D	Oxysterol-binding protein-related protein 1D	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8L751	ORP1C	Oxysterol-binding protein-related protein 1C	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MAATELRGVV	GPGPAAIAAL	GGGGAGPPVV	GGGGGRGDAG	PGSGAASGTV	VAAAAGGPGP
70	80	90	100	110	120
GAGGVAAAGP	APAPPTGGSG	GSGAGGSGSA	REGWLFKWTN	YIKGYQRRWF	VLSNGLLSYY
130	140	150	160	170	180
RSKAEMRHTC	RGTINLATAN	ITVEDSCNFI	ISNGGAQTYH	LKASSEVERQ	RWVTALELAK
190	200	210	220	230	240
AKAVKMLAES	DESGDEESVS	QTDKTELQNT	LRTLSSKVED	LSTCNDLIAK	HGTALQRSLS
250	260	270	280	290	300
ELESLKLPAE	SNEKIKQVNE	RATLFRITSN	AMINACRDFL	MLAQTHSKKW	QKSLQYERDQ
310	320	330	340	350	360
RIRLEETLEQ	LAKQHNHLER	AFRGATVLPA	NTPGNVGSGK	DQCCSGKGDM	SDEDDENEFF
370	380	390	400	410	420
DAPEIITMPE	NLGHKRTGSN	ISGASSDISL	DEQYKHQLEE	TKKEKRTRIP	YKPNYSLNLW
430	440	450	460	470	480
SIMKNCIGKE	LSKIPMPVNF	NEPLSMLQRL	TEDLEYHELL	DRAAKCENSL	EQLCYVAAFT
490	500	510	520	530	540
VSSYSTTVFR	TSKPFNPLLG	ETFELDRLEE	NGYRSLCEQV	SHHPPAAAHH	AESKNGWTLR
550	560	570	580	590	600
QEIKITSKFR	GKYLSIMPLG	TIHCIFHATG	HHYTWKKVTT	TVHNIIVGKL	WIDQSGEIDI
610	620	630	640	650	660
VNHKTGDKCN	LKFVPYSYFS	RDVARKVTGE	VTDPSGKVHF	ALLGTWDEKM	ECFKVQPVIG
670	680	690	700	710	720
ENGGDARQRG	HEAEESRVML	WKRNPLPKNA	ENMYYFSELA	LTLNAWESGT	APTDSRLRPD
730	740	750	760	770	780
QRLMENGRWD	EANAEKQRLE	EKQRLSRKKR	EAEAMKATED	GTPYDPYKAL	WFERKKDPVT
790	800
KELTHIYRGE	YWECKEKQDW	SSCPDIF