P63142

PR
Gene name
Kcna2
Protein name
Potassium voltage-gated channel subfamily A member 2
Names
RAK, RBK2, RCK5, Voltage-gated potassium channel subunit Kv1.2
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25468
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

392-494 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

17 structures for P63142

Entry ID Method Resolution Chain Position Source
1DSX X-ray 160 A A/B/C/D/E/F/G/H 33-119 PDB
1QDV X-ray 160 A A/B/C/D 33-131 PDB
1QDW X-ray 210 A A/B/C/D/E/F/G/H 33-119 PDB
2A79 X-ray 290 A B 1-499 PDB
2R9R X-ray 240 A B/H 1-499 PDB
3LNM X-ray 290 A PDB
3LUT X-ray 290 A B 1-499 PDB
4JTA X-ray 250 A PDB
4JTC X-ray 256 A PDB
4JTD X-ray 254 A PDB
5WIE X-ray 330 A B/H 1-42 PDB
6EBK EM 330 A PDB
6EBL EM 300 A PDB
6EBM EM 400 A PDB
7SIT X-ray 332 A B/D 1-499 PDB
7SIZ X-ray 310 A B/D 1-499 PDB
AF-P63142-F1 Predicted AlphaFoldDB

No variants for P63142

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P63142

No associated diseases with P63142

3 regional properties for P63142

Type Name Position InterPro Accession
domain BTB/POZ domain 33 - 133 IPR000210
domain Potassium channel tetramerisation-type BTB domain 35 - 125 IPR003131
domain Ion transport domain 163 - 420 IPR005821

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Membrane
  • Cell projection, axon
  • Synapse
  • Synapse, synaptosome
  • Presynaptic cell membrane
  • Cell projection, dendrite
  • Endoplasmic reticulum membrane
  • Cell projection, lamellipodium membrane
  • Endosome
  • Perikaryon
  • Cell junction, paranodal septate junction
  • KCNA2 by itself is detected both at the endoplasmic reticulum and at the cell membrane
  • Coexpression with KCNA4 or with beta subunits promotes expression at the cell membrane (PubMed:10896669, PubMed:16770729, PubMed:18003609)
  • Coexpression with KCNA1 inhibits cell surface expression (PubMed:10896669)
  • Surface levels are regulated both by steady-state and stimulus-induced clathrin-dependent endocytosis (PubMed:19403695)
  • Expression at the cell surface is down-regulated in response to CHRM1 activation (PubMed:9635436)
  • Expression at the cell surface is increased in response to the activation of beta-adrenergic receptors and increased cAMP levels (PubMed:18003609)
  • Detected on presynaptic and postsynaptic axon segments (PubMed:12777451)
  • In myelinated peripheral axons, clustered in the juxtaparadonal region and at an internodal line located along the mesaxon and below the Schmidt-Lanterman incisures (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

18 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axon initial segment Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
axon terminus Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
calyx of Held The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
endosome A vacuole to which materials ingested by endocytosis are delivered.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of presynaptic membrane The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
juxtaparanode region of axon A region of an axon near a node of Ranvier that is between the paranode and internode regions.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
lamellipodium membrane The portion of the plasma membrane surrounding a lamellipodium.
neuronal cell body membrane The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
paranodal junction A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
potassium channel complex An ion channel complex through which potassium ions pass.
voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

4 GO annotations of molecular function

Name Definition
delayed rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
kinesin binding Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
outward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force.
voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

9 GO annotations of biological process

Name Definition
neuronal action potential An action potential that occurs in a neuron.
optic nerve structural organization The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
potassium ion export across plasma membrane The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of circadian sleep/wake cycle, non-REM sleep Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.
regulation of dopamine secretion Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
sensory perception of pain The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q05037 KCNA4 Potassium voltage-gated channel subfamily A member 4 Bos taurus (Bovine) PR
Q7T199 KCNA10 Potassium voltage-gated channel subfamily A member 10 Gallus gallus (Chicken) PR
Q96RP8 KCNA7 Potassium voltage-gated channel subfamily A member 7 Homo sapiens (Human) PR
P22459 KCNA4 Potassium voltage-gated channel subfamily A member 4 Homo sapiens (Human) PR
P22001 KCNA3 Potassium voltage-gated channel subfamily A member 3 Homo sapiens (Human) PR
Q16322 KCNA10 Potassium voltage-gated channel subfamily A member 10 Homo sapiens (Human) PR
Q09470 KCNA1 Potassium voltage-gated channel subfamily A member 1 Homo sapiens (Human) PR
P16389 KCNA2 Potassium voltage-gated channel subfamily A member 2 Homo sapiens (Human) PR
Q61423 Kcna4 Potassium voltage-gated channel subfamily A member 4 Mus musculus (Mouse) PR
P16390 Kcna3 Potassium voltage-gated channel subfamily A member 3 Mus musculus (Mouse) PR
P16388 Kcna1 Potassium voltage-gated channel subfamily A member 1 Mus musculus (Mouse) PR
Q17ST2 Kcna7 Potassium voltage-gated channel subfamily A member 7 Mus musculus (Mouse) PR
P10499 Kcna1 Potassium voltage-gated channel subfamily A member 1 Rattus norvegicus (Rat) PR
P15384 Kcna3 Potassium voltage-gated channel subfamily A member 3 Rattus norvegicus (Rat) PR
Q9ER26 Kcns2 Potassium voltage-gated channel subfamily S member 2 Rattus norvegicus (Rat) PR
P15385 Kcna4 Potassium voltage-gated channel subfamily A member 4 Rattus norvegicus (Rat) PR
Q62897 Kcnd3 Potassium voltage-gated channel subfamily D member 3 Rattus norvegicus (Rat) PR
P15387 Kcnb1 Potassium voltage-gated channel subfamily B member 1 Rattus norvegicus (Rat) PR
O88944 Kcnq3 Potassium voltage-gated channel subfamily KQT member 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MTVATGDPVD EAAALPGHPQ DTYDPEADHE CCERVVINIS GLRFETQLKT LAQFPETLLG
70 80 90 100 110 120
DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR PVNVPLDIFS EEIRFYELGE
130 140 150 160 170 180
EAMEMFREDE GYIKEEERPL PENEFQRQVW LLFEYPESSG PARIIAIVSV MVILISIVSF
190 200 210 220 230 240
CLETLPIFRD ENEDMHGGGV TFHTYSNSTI GYQQSTSFTD PFFIVETLCI IWFSFEFLVR
250 260 270 280 290 300
FFACPSKAGF FTNIMNIIDI VAIIPYFITL GTELAEKPED AQQGQQAMSL AILRVIRLVR
310 320 330 340 350 360
VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE ADERDSQFPS
370 380 390 400 410 420
IPDAFWWAVV SMTTVGYGDM VPTTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE
430 440 450 460 470 480
TEGEEQAQYL QVTSCPKIPS SPDLKKSRSA STISKSDYME IQEGVNNSNE DFREENLKTA
490
NCTLANTNYV NITKMLTDV