P15385
PR
Gene name |
Kcna4 |
Protein name |
Potassium voltage-gated channel subfamily A member 4 |
Names |
RCK4, RHK1, RK3, Voltage-gated potassium channel subunit Kv1.4 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:25469 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P15385
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1KN7 | NMR | - | A | 1-75 | PDB |
| 1ZTO | NMR | - | A | 1-36 | PDB |
| AF-P15385-F1 | Predicted | AlphaFoldDB |
No variants for P15385
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P15385 | |||||
No associated diseases with P15385
4 regional properties for P15385
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | BTB/POZ domain | 178 - 278 | IPR000210 |
| domain | Potassium channel tetramerisation-type BTB domain | 180 - 268 | IPR003131 |
| domain | Ion transport domain | 312 - 572 | IPR005821 |
| domain | Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain | 1 - 74 | IPR012897 |
14 GO annotations of cellular component
| Name | Definition |
|---|---|
| asymmetric synapse | A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| axon initial segment | Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| dendritic shaft | Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of postsynaptic membrane | The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of presynaptic membrane | The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| voltage-gated potassium channel complex | A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| delayed rectifier potassium channel activity | Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. |
| ion channel activity | Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). |
| potassium channel activity | Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| potassium ion binding | Binding to a potassium ion (K+). |
| voltage-gated potassium channel activity | Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05037 | KCNA4 | Potassium voltage-gated channel subfamily A member 4 | Bos taurus (Bovine) | PR |
| Q7T199 | KCNA10 | Potassium voltage-gated channel subfamily A member 10 | Gallus gallus (Chicken) | PR |
| Q96RP8 | KCNA7 | Potassium voltage-gated channel subfamily A member 7 | Homo sapiens (Human) | PR |
| P22001 | KCNA3 | Potassium voltage-gated channel subfamily A member 3 | Homo sapiens (Human) | PR |
| Q16322 | KCNA10 | Potassium voltage-gated channel subfamily A member 10 | Homo sapiens (Human) | PR |
| Q09470 | KCNA1 | Potassium voltage-gated channel subfamily A member 1 | Homo sapiens (Human) | PR |
| P16389 | KCNA2 | Potassium voltage-gated channel subfamily A member 2 | Homo sapiens (Human) | PR |
| P22459 | KCNA4 | Potassium voltage-gated channel subfamily A member 4 | Homo sapiens (Human) | PR |
| P16390 | Kcna3 | Potassium voltage-gated channel subfamily A member 3 | Mus musculus (Mouse) | PR |
| P16388 | Kcna1 | Potassium voltage-gated channel subfamily A member 1 | Mus musculus (Mouse) | PR |
| Q17ST2 | Kcna7 | Potassium voltage-gated channel subfamily A member 7 | Mus musculus (Mouse) | PR |
| Q61423 | Kcna4 | Potassium voltage-gated channel subfamily A member 4 | Mus musculus (Mouse) | PR |
| P15384 | Kcna3 | Potassium voltage-gated channel subfamily A member 3 | Rattus norvegicus (Rat) | PR |
| P63142 | Kcna2 | Potassium voltage-gated channel subfamily A member 2 | Rattus norvegicus (Rat) | PR |
| P10499 | Kcna1 | Potassium voltage-gated channel subfamily A member 1 | Rattus norvegicus (Rat) | PR |
| Q62897 | Kcnd3 | Potassium voltage-gated channel subfamily D member 3 | Rattus norvegicus (Rat) | PR |
| Q9ER26 | Kcns2 | Potassium voltage-gated channel subfamily S member 2 | Rattus norvegicus (Rat) | PR |
| P15387 | Kcnb1 | Potassium voltage-gated channel subfamily B member 1 | Rattus norvegicus (Rat) | PR |
| O88944 | Kcnq3 | Potassium voltage-gated channel subfamily KQT member 3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEVAMVSAES | SGCNSHMPYG | YAAQARARER | ERLAHSRAAA | AAAVAAATAA | VEGTGGSGGG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PHHHHQTRGA | YSSHDPQGSR | GSREEEATRT | EKKKKLHHRQ | SSFPHCSDLM | PSGSEEKILR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELSEEEEDEE | EEEEEEEEGR | FYYSEEDHGD | GCSYTDLLPQ | DDGGGGGYSS | VRYSDCCERV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VINVSGLRFE | TQMKTLAQFP | ETLLGDPEKR | TQYFDPLRNE | YFFDRNRPSF | DAILYYYQSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GRLKRPVNVP | FDIFTEEVKF | YQLGEEALLK | FREDEGFVRE | EEDRALPENE | FKKQIWLLFE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YPESSSPARG | IAIVSVLVIL | ISIVIFCLET | LPEFRDDRDL | IMALSAGGHS | RLLNDTSAPH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LENSGHTIFN | DPFFIVETVC | IVWFSFEFVV | RCFACPSQAL | FFKNIMNIID | IVSILPYFIT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LGTDLAQQQG | GGNGQQQQAM | SFAILRIIRL | VRVFRIFKLS | RHSKGLQILG | HTLRASMREL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GLLIFFLFIG | VILFSSAVYF | AEADEPTTHF | QSIPDAFWWA | VVTMTTVGYG | DMKPITVGGK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IVGSLCAIAG | VLTIALPVPV | IVSNFNYFYH | RETENEEQTQ | LTQNAVSCPY | LPSNLLKKFR |
| 610 | 620 | 630 | 640 | 650 | |
| SSTSSSLGDK | SEYLEMEEGV | KESLCGKEEK | CQGKGDDSET | DKNNCSNAKA | VETDV |