Q7T199

PR
Gene name
KCNA10
Protein name
Potassium voltage-gated channel subfamily A member 10
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395116
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

445-516 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7T199

Entry ID Method Resolution Chain Position Source
AF-Q7T199-F1 Predicted AlphaFoldDB

29 variants for Q7T199

Variant ID(s) Position Change Description Diseaes Association Provenance
rs735105571 10 M>R No Ensembl
rs733031903 12 V>G No Ensembl
rs735668130 32 D>A No Ensembl
rs739416509 33 L>P No Ensembl
rs316025449 34 S>T No Ensembl
rs735214711 74 E>G No Ensembl
rs739970614 80 V>G No Ensembl
rs732052839 84 V>G No Ensembl
rs740883012 87 E>G No Ensembl
rs731258309 108 T>P No Ensembl
rs741738772 122 K>E No Ensembl
rs737347183 218 S>R No Ensembl
rs735292583 242 T>P No Ensembl
rs735838506 325 T>P No Ensembl
rs738870510 362 H>P No Ensembl
rs740080358 405 E>G No Ensembl
rs732220412 413 I>L No Ensembl
rs741048558 425 T>A No Ensembl
rs1060312506 448 I>T No Ensembl
rs1057580890 449 A>V No Ensembl
rs1060445586 450 G>E No Ensembl
rs1058265883 451 V>A No Ensembl
rs1058048147 452 L>P No Ensembl
rs1057950243 463 S>* No Ensembl
rs1058860260 466 N>D No Ensembl
rs1060125085 467 Y>N No Ensembl
rs740613293 480 I>L No Ensembl
rs734415880 486 E>G No Ensembl
rs732350395 492 V>G No Ensembl

No associated diseases with Q7T199

3 regional properties for Q7T199

Type Name Position InterPro Accession
domain BTB/POZ domain 91 - 191 IPR000210
domain Potassium channel tetramerisation-type BTB domain 93 - 184 IPR003131
domain Ion transport domain 224 - 472 IPR005821

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

2 GO annotations of molecular function

Name Definition
delayed rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

3 GO annotations of biological process

Name Definition
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q05037 KCNA4 Potassium voltage-gated channel subfamily A member 4 Bos taurus (Bovine) PR
Q96RP8 KCNA7 Potassium voltage-gated channel subfamily A member 7 Homo sapiens (Human) PR
P22459 KCNA4 Potassium voltage-gated channel subfamily A member 4 Homo sapiens (Human) PR
P22001 KCNA3 Potassium voltage-gated channel subfamily A member 3 Homo sapiens (Human) PR
Q09470 KCNA1 Potassium voltage-gated channel subfamily A member 1 Homo sapiens (Human) PR
P16389 KCNA2 Potassium voltage-gated channel subfamily A member 2 Homo sapiens (Human) PR
Q16322 KCNA10 Potassium voltage-gated channel subfamily A member 10 Homo sapiens (Human) PR
Q61423 Kcna4 Potassium voltage-gated channel subfamily A member 4 Mus musculus (Mouse) PR
P16390 Kcna3 Potassium voltage-gated channel subfamily A member 3 Mus musculus (Mouse) PR
P16388 Kcna1 Potassium voltage-gated channel subfamily A member 1 Mus musculus (Mouse) PR
Q17ST2 Kcna7 Potassium voltage-gated channel subfamily A member 7 Mus musculus (Mouse) PR
P15385 Kcna4 Potassium voltage-gated channel subfamily A member 4 Rattus norvegicus (Rat) PR
P15384 Kcna3 Potassium voltage-gated channel subfamily A member 3 Rattus norvegicus (Rat) PR
P10499 Kcna1 Potassium voltage-gated channel subfamily A member 1 Rattus norvegicus (Rat) PR
P63142 Kcna2 Potassium voltage-gated channel subfamily A member 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MMDVSSWKEM EVALVSFDNA DQIVEDPCYS NDLSPASQSR KGHPSCANLL SNWRILINSE
70 80 90 100 110 120
NANNETIFSR FSAEFSEHLV GERVGMEEGD QRVIINIAGL RFETRLKTLN QFPETLLGDP
130 140 150 160 170 180
EKRMRYFDSM RNEYFFDRNR PSFDGILYYY QSGGKIRRPA NVPIDVFADE ITFYELGDEA
190 200 210 220 230 240
MDQFREDEGF IKDPETLLPT NDFHRQFWLL FEYPESSSAA RGVALVSVLV IVISIIIFCM
250 260 270 280 290 300
ETLPEFREER EYKSTQELSK NTTDTLLAHS TFTDPFFVIE TACIIWFSFE LFVRFIVCPS
310 320 330 340 350 360
KTEFFKNIMN IIDIVSIIPY FVTLTTELIQ QSELNGQQNM SLAILRIIRL VRVFRIFKLS
370 380 390 400 410 420
RHSKGLQILG QTLKASMREL GLLIFFLFIG VILFSSAVYF AEVDEPQSHF SSIPDGFWWA
430 440 450 460 470 480
VVTMTTVGYG DMCPTTLGGK IVGTLCAIAG VLTIALPVPV IVSNFNYFYH RETENEEKQI
490 500 510
LPGEVERILN SVVTGNDSME SLNKTNGGYP RDKAKK