Q62897

PR
Gene name
Kcnd3
Protein name
Potassium voltage-gated channel subfamily D member 3
Names
Voltage-gated potassium channel subunit Kv4.3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:65195
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

497-605 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q62897

Entry ID Method Resolution Chain Position Source
2I2R X-ray 335 A A/B/C/D/I/J/K/L 2-143 PDB
AF-Q62897-F1 Predicted AlphaFoldDB

No variants for Q62897

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q62897

No associated diseases with Q62897

5 regional properties for Q62897

Type Name Position InterPro Accession
domain BTB/POZ domain 40 - 139 IPR000210
domain Potassium channel tetramerisation-type BTB domain 42 - 131 IPR003131
domain Ion transport domain 184 - 413 IPR005821
domain Shal-type voltage-gated potassium channels, N-terminal 3 - 31 IPR021645
domain Potassium channel, voltage dependent, Kv4, C-terminal 469 - 562 IPR024587

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Cell membrane, sarcolemma ; Multi-pass membrane protein
  • Cell projection, dendrite
  • Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

17 GO annotations of cellular component

Name Definition
caveola A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
GABA-ergic synapse A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of postsynaptic specialization membrane The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
perinuclear endoplasmic reticulum The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
potassium channel complex An ion channel complex through which potassium ions pass.
sarcolemma The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

6 GO annotations of molecular function

Name Definition
A-type (transient outward) potassium channel activity Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential.
ion channel activity Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
metal ion binding Binding to a metal ion.
potassium channel activity Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

11 GO annotations of biological process

Name Definition
cellular response to BMP stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus.
membrane repolarization The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
membrane repolarization during ventricular cardiac muscle cell action potential The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
potassium ion export across plasma membrane The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.
potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
potassium ion transport The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of heart rate by cardiac conduction A cardiac conduction process that modulates the frequency or rate of heart contraction.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
ventricular cardiac muscle cell membrane repolarization The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UK17 KCND3 Potassium voltage-gated channel subfamily D member 3 Homo sapiens (Human) PR
Q9Z0V1 Kcnd3 Potassium voltage-gated channel subfamily D member 3 Mus musculus (Mouse) PR
P15385 Kcna4 Potassium voltage-gated channel subfamily A member 4 Rattus norvegicus (Rat) PR
P15384 Kcna3 Potassium voltage-gated channel subfamily A member 3 Rattus norvegicus (Rat) PR
P63142 Kcna2 Potassium voltage-gated channel subfamily A member 2 Rattus norvegicus (Rat) PR
P10499 Kcna1 Potassium voltage-gated channel subfamily A member 1 Rattus norvegicus (Rat) PR
Q9ER26 Kcns2 Potassium voltage-gated channel subfamily S member 2 Rattus norvegicus (Rat) PR
P15387 Kcnb1 Potassium voltage-gated channel subfamily B member 1 Rattus norvegicus (Rat) PR
O88944 Kcnq3 Potassium voltage-gated channel subfamily KQT member 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAAGVAAWLP FARAAAIGWM PVANCPMPLA PADKNKRQDE LIVLNVSGRR FQTWRTTLER
70 80 90 100 110 120
YPDTLLGSTE KEFFFNEDTK EYFFDRDPEV FRCVLNFYRT GKLHYPRYEC ISAYDDELAF
130 140 150 160 170 180
YGILPEIIGD CCYEEYKDRK RENAERLMDD NESENNQESM PSLSFRQTMW RAFENPHTST
190 200 210 220 230 240
LALVFYYVTG FFIAVSVITN VVETVPCGTV PGSKELPCGE RYSVAFFCLD TACVMIFTVE
250 260 270 280 290 300
YLLRLFAAPS RYRFIRSVMS IIDVVAIMPY YIGLVMTNNE DVSGAFVTLR VFRVFRIFKF
310 320 330 340 350 360
SRHSQGLRIL GYTLKSCASE LGFLLFSLTM AIIIFATVMF YAEKGSSASK FTSIPASFWY
370 380 390 400 410 420
TIVTMTTLGY GDMVPKTIAG KIFGSICSLS GVLVIALPVP VIVSNFSRIY HQNQRADKRR
430 440 450 460 470 480
AQKKARLARI RVAKTGSSNA YLHSKRNGLL NEALELTGTP EEEHMGKTTS LIESQHHHLL
490 500 510 520 530 540
HCLEKTTGLS YLVDDPLLSV RTSTIKNHEF IDEQMFEQNC MESSMQNYPS TRSPSLSSHS
550 560 570 580 590 600
GLTTTCCSRR SKKTTHLPNS NLPATRLRSM QELSTIHIQG SEQPSLTTSR SSLNLKADDG
610 620 630 640 650
LRPNCKTSQI TTAIISIPTP PALTPEGESR PPPASPGPNT NIPSITSNVV KVSVL