O70370

PR
Gene name
Ctss (Cats)
Protein name
Cathepsin S
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:13040
EC number
3.4.22.27: Cysteine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

71-146 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for O70370

Entry ID Method Resolution Chain Position Source
4BPV X-ray 200 A A/B/C/D/E/K 116-340 PDB
4BQV X-ray 170 A A/B/C/D/E/F/G/H 116-340 PDB
4BS5 X-ray 125 A A 116-340 PDB
4BS6 X-ray 120 A A/B 116-340 PDB
4BSQ X-ray 196 A A 116-340 PDB
4MZO X-ray 147 A A/B/C/D/E/F/G/H 116-340 PDB
4MZS X-ray 185 A A/B 116-340 PDB
AF-O70370-F1 Predicted AlphaFoldDB

17 variants for O70370

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388642662 38 L>I No EVA
rs250718036 72 L>F No EVA
rs228354008 97 L>S No EVA
rs246388285 99 R>Q No EVA
rs3388642975 101 G>D No EVA
rs3388648662 103 L>M No EVA
rs217318565 106 P>L No EVA
rs3388646409 114 T>S No EVA
rs3388651698 126 T>A No EVA
rs3388645023 132 K>N No EVA
rs3388645062 145 G>R No EVA
rs3388644615 168 I>L No EVA
rs253031261 187 K>E No EVA
rs220525835 218 T>M No EVA
rs3388649821 269 F>I No EVA
rs3388648709 279 P>L No EVA
rs33128450 334 Y>D No EVA

No associated diseases with O70370

6 regional properties for O70370

Type Name Position InterPro Accession
active_site Cysteine peptidase, cysteine active site 141 - 152 IPR000169
domain Peptidase C1A, papain C-terminal 123 - 339 IPR000668
domain Cathepsin propeptide inhibitor domain (I29) 36 - 96 IPR013201
active_site Cysteine peptidase, histidine active site 285 - 295 IPR025660
active_site Cysteine peptidase, asparagine active site 302 - 321 IPR025661
domain Papain-like cysteine endopeptidase 124 - 338 IPR039417

Functions

Description
EC Number 3.4.22.27 Cysteine endopeptidases
Subcellular Localization
  • Lysosome
  • Secreted
  • Cytoplasmic vesicle, phagosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
early endosome lumen The volume enclosed by the membrane of an early endosome.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

7 GO annotations of molecular function

Name Definition
collagen binding Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
cysteine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
cysteine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
fibronectin binding Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
laminin binding Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells.
peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
proteoglycan binding Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

13 GO annotations of biological process

Name Definition
antigen processing and presentation of exogenous peptide antigen via MHC class II The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
antigen processing and presentation of peptide antigen The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.
basement membrane disassembly The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.
bone resorption The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
collagen catabolic process The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.
immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
positive regulation of cation channel activity Any process that activates or increases the frequency, rate or extent of cation channel activity.
positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response.
protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
proteolysis involved in protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
regulation of sensory perception of pain Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
response to acidic pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P09668 CTSH Pro-cathepsin H Homo sapiens (Human) PR
P49935 Ctsh Pro-cathepsin H Mus musculus (Mouse) PR
P56203 Ctsw Cathepsin W Mus musculus (Mouse) PR
Q8BM88 Ctso Cathepsin O Mus musculus (Mouse) PR
P00786 Ctsh Pro-cathepsin H Rattus norvegicus (Rat) PR
P22895 P34 probable thiol protease Glycine max (Soybean) (Glycine hispida) PR
O65493 XCP1 Cysteine protease XCP1 Arabidopsis thaliana (Mouse-ear cress) PR
Q94B08 GCP1 Germination-specific cysteine protease 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LT77 RDL2 Probable cysteine protease RDL2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRAPGHAAIR WLFWMPLVCS VAMEQLQRDP TLDYHWDLWK KTHEKEYKDK NEEEVRRLIW
70 80 90 100 110 120
EKNLKFIMIH NLEYSMGMHT YQVGMNDMGD MTNEEILCRM GALRIPRQSP KTVTFRSYSN
130 140 150 160 170 180
RTLPDTVDWR EKGCVTEVKY QGSCGACWAF SAVGALEGQL KLKTGKLISL SAQNLVDCSN
190 200 210 220 230 240
EEKYGNKGCG GGYMTEAFQY IIDNGGIEAD ASYPYKATDE KCHYNSKNRA ATCSRYIQLP
250 260 270 280 290 300
FGDEDALKEA VATKGPVSVG IDASHSSFFF YKSGVYDDPS CTGNVNHGVL VVGYGTLDGK
310 320 330
DYWLVKNSWG LNFGDQGYIR MARNNKNHCG IASYCSYPEI