Q8BM88

PR
Gene name
Ctso
Protein name
Cathepsin O
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:229445
EC number
3.4.22.42: Cysteine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-121 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BM88

Entry ID Method Resolution Chain Position Source
AF-Q8BM88-F1 Predicted AlphaFoldDB

14 variants for Q8BM88

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388631798 11 L>V No EVA
rs260200478 18 R>H No EVA
rs13459564 19 H>R No EVA
rs3388638464 49 F>V No EVA
rs248508771 65 Y>H No EVA
rs249278726 80 Y>S No EVA
rs3388635399 83 A>T No EVA
rs3388630181 93 P>L No EVA
rs3388630230 112 N>K No EVA
rs3388617533 221 E>G No EVA
rs3388628220 229 F>C No EVA
rs3388635487 296 M>L No EVA
rs864271104 303 I>V No EVA
rs108731619 304 A>T No EVA

No associated diseases with Q8BM88

4 regional properties for Q8BM88

Type Name Position InterPro Accession
active_site Cysteine peptidase, cysteine active site 117 - 128 IPR000169
domain Peptidase C1A, papain C-terminal 99 - 311 IPR000668
active_site Cysteine peptidase, histidine active site 258 - 268 IPR025660
domain Papain-like cysteine endopeptidase 100 - 305 IPR039417

Functions

Description
EC Number 3.4.22.42 Cysteine endopeptidases
Subcellular Localization
  • Lysosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

1 GO annotations of molecular function

Name Definition
cysteine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

1 GO annotations of biological process

Name Definition
proteolysis involved in protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P56202 CTSW Cathepsin W Homo sapiens (Human) PR
P43234 CTSO Cathepsin O Homo sapiens (Human) PR
P56203 Ctsw Cathepsin W Mus musculus (Mouse) PR
O70370 Ctss Cathepsin S Mus musculus (Mouse) PR
P49935 Ctsh Pro-cathepsin H Mus musculus (Mouse) PR
P43296 RD19A Cysteine protease RD19A Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKPQLVNLLL LCCCCLGRHG VAGTWSWSHQ REAAALRESL HRHRYLNSFP HENSTAFYGV
70 80 90 100 110 120
NQFSYLFPEE FKALYLGSKY AWAPRYPAEG QRPIPNVSLP LRFDWRDKHV VNPVRNQEMC
130 140 150 160 170 180
GGCWAFSVVS AIESARAIQG KSLDYLSVQQ VIDCSFNNSG CLGGSPLCAL RWLNETQLKL
190 200 210 220 230 240
VADSQYPFKA VNGQCRHFPQ SQAGVSVKDF SAYNFRGQED EMARALLSFG PLVVIVDAMS
250 260 270 280 290 300
WQDYLGGIIQ HHCSSGEANH AVLITGFDRT GNTPYWMVRN SWGSSWGVEG YAHVKMGGNV
310
CGIADSVAAV FV