P56203
Gene name |
Ctsw |
Protein name |
Cathepsin W |
Names |
Lymphopain |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13041 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P56203
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P56203-F1 | Predicted | AlphaFoldDB |
28 variants for P56203
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs16789981 | 26 | T>I | No | EVA | |
| rs3389427626 | 29 | A>V | No | EVA | |
| rs3389517649 | 42 | L>M | No | EVA | |
| rs3389521788 | 44 | Q>H | No | EVA | |
| rs3389517665 | 53 | N>D | No | EVA | |
| rs3389512056 | 105 | R>K | No | EVA | |
| rs16790002 | 108 | E>K | No | EVA | |
| rs3389510548 | 138 | I>T | No | EVA | |
| rs16790003 | 146 | G>E | No | EVA | |
| rs3389531099 | 147 | S>R | No | EVA | |
| rs16790005 | 171 | F>L | No | EVA | |
| rs3389511977 | 211 | K>* | No | EVA | |
| rs3389527586 | 218 | D>N | No | EVA | |
| rs3389485081 | 223 | R>T | No | EVA | |
| rs16790013 | 250 | H>R | No | EVA | |
| rs16790014 | 254 | V>M | No | EVA | |
| rs3389510517 | 279 | P>L | No | EVA | |
| rs3389466014 | 282 | C>S | No | EVA | |
| rs3389427650 | 292 | L>M | No | EVA | |
| rs3409288365 | 305 | T>K | No | EVA | |
| rs3389518680 | 319 | S>F | No | EVA | |
| rs3389532905 | 330 | A>S | No | EVA | |
| rs211894509 | 331 | H>Q | No | EVA | |
| rs3389485107 | 347 | C>R | No | EVA | |
| rs16790016 | 349 | V>I | No | EVA | |
| rs3389527570 | 358 | V>M | No | EVA | |
| rs225000819 | 366 | R>Q | No | EVA | |
| rs16789887 | 367 | T>I | No | EVA |
No associated diseases with P56203
5 regional properties for P56203
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase C1A, papain C-terminal | 126 - 357 | IPR000668 |
| domain | Cathepsin propeptide inhibitor domain (I29) | 40 - 97 | IPR013201 |
| active_site | Cysteine peptidase, histidine active site | 287 - 297 | IPR025660 |
| active_site | Cysteine peptidase, asparagine active site | 321 - 340 | IPR025661 |
| domain | Papain-like cysteine endopeptidase | 127 - 356 | IPR039417 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proteolysis involved in protein catabolic process | The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43234 | CTSO | Cathepsin O | Homo sapiens (Human) | PR |
| P56202 | CTSW | Cathepsin W | Homo sapiens (Human) | PR |
| Q8BM88 | Ctso | Cathepsin O | Mus musculus (Mouse) | PR |
| O70370 | Ctss | Cathepsin S | Mus musculus (Mouse) | PR |
| P49935 | Ctsh | Pro-cathepsin H | Mus musculus (Mouse) | PR |
| P43296 | RD19A | Cysteine protease RD19A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTLTAHLSYF | LVLLLAGQGL | SDSLLTKDAG | PRPLELKEVF | KLFQIRFNRS | YWNPAEYTRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LSIFAHNLAQ | AQRLQQEDLG | TAEFGETPFS | DLTEEEFGQL | YGQERSPERT | PNMTKKVESN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TWGESVPRTC | DWRKAKNIIS | SVKNQGSCKC | CWAMAAADNI | QALWRIKHQQ | FVDVSVQELL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DCERCGNGCN | GGFVWDAYLT | VLNNSGLASE | KDYPFQGDRK | PHRCLAKKYK | KVAWIQDFTM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSNNEQAIAH | YLAVHGPITV | TINMKLLQHY | QKGVIKATPS | SCDPRQVDHS | VLLVGFGKEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EGMQTGTVLS | HSRKRRHSSP | YWILKNSWGA | HWGEKGYFRL | YRGNNTCGVT | KYPFTAQVDS |
| 370 | |||||
| PVKKARTSCP | P |