P43296
PR
Gene name |
RD19A |
Protein name |
Cysteine protease RD19A |
Names |
Protein RESPONSIVE TO DEHYDRATION 19, RD19 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G39090 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P43296
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P43296-F1 | Predicted | AlphaFoldDB |
19 variants for P43296
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_18217305_A_G | 8 | F>L | No | 1000Genomes | |
| ENSVATH14359678 | 13 | L>M | No | 1000Genomes | |
| ENSVATH02978677 | 15 | F>L | No | 1000Genomes | |
| ENSVATH02978676 | 19 | S>L | No | 1000Genomes | |
| tmp_4_18217254_C_T,G | 25 | V>I | No | 1000Genomes | |
| tmp_4_18217254_C_T,G | 25 | V>L | No | 1000Genomes | |
| tmp_4_18217152_C_A,T | 59 | G>R | No | 1000Genomes | |
| tmp_4_18217152_C_A,T | 59 | G>W | No | 1000Genomes | |
| ENSVATH02978675 | 77 | A>T | No | 1000Genomes | |
| ENSVATH12495331 | 84 | R>H | No | 1000Genomes | |
| tmp_4_18217049_G_C | 93 | T>S | No | 1000Genomes | |
| ENSVATH06851736 | 111 | H>Y | No | 1000Genomes | |
| ENSVATH12495329 | 175 | A>S | No | 1000Genomes | |
| tmp_4_18216655_G_A | 187 | L>F | No | 1000Genomes | |
| ENSVATH12495312 | 323 | P>S | No | 1000Genomes | |
| ENSVATH06851729 | 333 | E>D | No | 1000Genomes | |
| ENSVATH02978673 | 368 | H>N | No | 1000Genomes | |
| ENSVATH02978673 | 368 | H>Y | No | 1000Genomes | |
| ENSVATH04355290 | 369 | H>del | No | 1000Genomes |
No associated diseases with P43296
6 regional properties for P43296
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Cysteine peptidase, cysteine active site | 153 - 164 | IPR000169 |
| domain | Peptidase C1A, papain C-terminal | 135 - 360 | IPR000668 |
| domain | Cathepsin propeptide inhibitor domain (I29) | 51 - 107 | IPR013201 |
| active_site | Cysteine peptidase, histidine active site | 300 - 310 | IPR025660 |
| active_site | Cysteine peptidase, asparagine active site | 324 - 343 | IPR025661 |
| domain | Papain-like cysteine endopeptidase | 136 - 359 | IPR039417 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| lytic vacuole | A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| proteolysis involved in protein catabolic process | The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. |
| response to osmotic stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. |
| response to salt stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43234 | CTSO | Cathepsin O | Homo sapiens (Human) | PR |
| P56202 | CTSW | Cathepsin W | Homo sapiens (Human) | PR |
| P56203 | Ctsw | Cathepsin W | Mus musculus (Mouse) | PR |
| Q8BM88 | Ctso | Cathepsin O | Mus musculus (Mouse) | PR |
| Q9LT77 | RDL2 | Probable cysteine protease RDL2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O65493 | XCP1 | Cysteine protease XCP1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94B08 | GCP1 | Germination-specific cysteine protease 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRLKLYFSV | FVLSFFIVSV | SSSDVNDGDD | LVIRQVVGGA | EPQVLTSEDH | FSLFKRKFGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VYASNEEHDY | RFSVFKANLR | RARRHQKLDP | SATHGVTQFS | DLTRSEFRKK | HLGVRSGFKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKDANKAPIL | PTENLPEDFD | WRDHGAVTPV | KNQGSCGSCW | SFSATGALEG | ANFLATGKLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLSEQQLVDC | DHECDPEEAD | SCDSGCNGGL | MNSAFEYTLK | TGGLMKEEDY | PYTGKDGKTC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLDKSKIVAS | VSNFSVISID | EEQIAANLVK | NGPLAVAINA | GYMQTYIGGV | SCPYICTRRL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NHGVLLVGYG | AAGYAPARFK | EKPYWIIKNS | WGETWGENGF | YKICKGRNIC | GVDSMVSTVA |
| ATVSTTAH |