O65493
Gene name |
XCP1 |
Protein name |
Cysteine protease XCP1 |
Names |
Xylem cysteine peptidase 1, AtXCP1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G35350 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O65493
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O65493-F1 | Predicted | AlphaFoldDB |
21 variants for O65493
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14340588 | 5 | A>V | No | 1000Genomes | |
| tmp_4_16810547_T_A | 7 | S>T | No | 1000Genomes | |
| tmp_4_16810587_C_T | 20 | S>L | No | 1000Genomes | |
| tmp_4_16810595_C_G | 23 | L>V | No | 1000Genomes | |
| tmp_4_16810614_G_T | 29 | R>L | No | 1000Genomes | |
| ENSVATH06828946 | 47 | L>F | No | 1000Genomes | |
| ENSVATH02960568 | 64 | S>G | No | 1000Genomes | |
| ENSVATH12407878 | 85 | R>G | No | 1000Genomes | |
| ENSVATH12407879 | 100 | A>V | No | 1000Genomes | |
| tmp_4_16810887_C_T | 120 | S>F | No | 1000Genomes | |
| ENSVATH00553558 | 127 | A>D | No | 1000Genomes | |
| ENSVATH14340589 | 132 | R>S | No | 1000Genomes | |
| tmp_4_16810944_A_C | 139 | K>T | No | 1000Genomes | |
| tmp_4_16811170_C_T | 183 | S>L | No | 1000Genomes | |
| tmp_4_16811269_G_A | 216 | G>D | No | 1000Genomes | |
| tmp_4_16811481_A_T | 257 | E>V | No | 1000Genomes | |
| tmp_4_16811705_G_T | 300 | A>S | No | 1000Genomes | |
| tmp_4_16811709_C_G | 301 | A>G | No | 1000Genomes | |
| tmp_4_16811768_C_G | 321 | P>A | No | 1000Genomes | |
| ENSVATH14340593 | 325 | E>D | No | 1000Genomes | |
| ENSVATH06828954 | 332 | K>E | No | 1000Genomes |
No associated diseases with O65493
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| programmed cell death involved in cell development | The activation of endogenous cellular processes that result in the death of a cell as part of its development. |
| proteolysis involved in protein catabolic process | The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P09668 | CTSH | Pro-cathepsin H | Homo sapiens (Human) | PR |
| O70370 | Ctss | Cathepsin S | Mus musculus (Mouse) | PR |
| P49935 | Ctsh | Pro-cathepsin H | Mus musculus (Mouse) | PR |
| P00786 | Ctsh | Pro-cathepsin H | Rattus norvegicus (Rat) | PR |
| P22895 | P34 probable thiol protease | Glycine max (Soybean) (Glycine hispida) | PR | |
| Q94B08 | GCP1 | Germination-specific cysteine protease 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LT77 | RDL2 | Probable cysteine protease RDL2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43296 | RD19A | Cysteine protease RD19A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFSAPSLSK | FSLLVAISAS | ALLCCAFARD | FSIVGYTPEH | LTNTDKLLEL | FESWMSEHSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AYKSVEEKVH | RFEVFRENLM | HIDQRNNEIN | SYWLGLNEFA | DLTHEEFKGR | YLGLAKPQFS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RKRQPSANFR | YRDITDLPKS | VDWRKKGAVA | PVKDQGQCGS | CWAFSTVAAV | EGINQITTGN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSSLSEQELI | DCDTTFNSGC | NGGLMDYAFQ | YIISTGGLHK | EDDYPYLMEE | GICQEQKEDV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ERVTISGYED | VPENDDESLV | KALAHQPVSV | AIEASGRDFQ | FYKGGVFNGK | CGTDLDHGVA |
| 310 | 320 | 330 | 340 | 350 | |
| AVGYGSSKGS | DYVIVKNSWG | PRWGEKGFIR | MKRNTGKPEG | LCGINKMASY | PTKTK |