P22895

PR
Gene name
Protein name
P34 probable thiol protease
Names
Species
Glycine max (Soybean) (Glycine hispida)
KEGG Pathway
gmx:548062
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-161 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P22895

Entry ID Method Resolution Chain Position Source
AF-P22895-F1 Predicted AlphaFoldDB

No variants for P22895

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P22895

No associated diseases with P22895

4 regional properties for P22895

Type Name Position InterPro Accession
domain Peptidase C1A, papain C-terminal 135 - 356 IPR000668
domain Cathepsin propeptide inhibitor domain (I29) 44 - 103 IPR013201
active_site Cysteine peptidase, asparagine active site 316 - 335 IPR025661
domain Papain-like cysteine endopeptidase 136 - 355 IPR039417

Functions

Description
EC Number
Subcellular Localization
  • Vacuole
  • Protein storage vacuoles of seeds
  • This protein was wrongly thought to be associated with seed oil bodies
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

1 GO annotations of molecular function

Name Definition
cysteine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

1 GO annotations of biological process

Name Definition
proteolysis involved in protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P09668 CTSH Pro-cathepsin H Homo sapiens (Human) PR
O70370 Ctss Cathepsin S Mus musculus (Mouse) PR
P49935 Ctsh Pro-cathepsin H Mus musculus (Mouse) PR
P00786 Ctsh Pro-cathepsin H Rattus norvegicus (Rat) PR
Q9LT77 RDL2 Probable cysteine protease RDL2 Arabidopsis thaliana (Mouse-ear cress) PR
O65493 XCP1 Cysteine protease XCP1 Arabidopsis thaliana (Mouse-ear cress) PR
Q94B08 GCP1 Germination-specific cysteine protease 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGFLVLLLFS LLGLSSSSSI STHRSILDLD LTKFTTQKQV SSLFQLWKSE HGRVYHNHEE
70 80 90 100 110 120
EAKRLEIFKN NSNYIRDMNA NRKSPHSHRL GLNKFADITP QEFSKKYLQA PKDVSQQIKM
130 140 150 160 170 180
ANKKMKKEQY SCDHPPASWD WRKKGVITQV KYQGGCGRGW AFSATGAIEA AHAIATGDLV
190 200 210 220 230 240
SLSEQELVDC VEESEGSYNG WQYQSFEWVL EHGGIATDDD YPYRAKEGRC KANKIQDKVT
250 260 270 280 290 300
IDGYETLIMS DESTESETEQ AFLSAILEQP ISVSIDAKDF HLYTGGIYDG ENCTSPYGIN
310 320 330 340 350 360
HFVLLVGYGS ADGVDYWIAK NSWGFDWGED GYIWIQRNTG NLLGVCGMNY FASYPTKEES
370
ETLVSARVKG HRRVDHSPL