Q9LT77
Gene name |
RDL2 |
Protein name |
Probable cysteine protease RDL2 |
Names |
Probable cysteine proteinase At3g19400, RD21A-like protease 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G19400 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LT77
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LT77-F1 | Predicted | AlphaFoldDB |
38 variants for Q9LT77
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05863134 | 29 | T>A | No | 1000Genomes | |
| tmp_3_6725681_C_A | 58 | L>I | No | 1000Genomes | |
| ENSVATH10782553 | 64 | R>* | No | 1000Genomes | |
| ENSVATH00334163 | 65 | F>S | No | 1000Genomes | |
| ENSVATH00334165 | 97 | T>P | No | 1000Genomes | |
| tmp_3_6725822_T_C | 105 | Y>H | No | 1000Genomes | |
| tmp_3_6725826_T_C | 106 | L>S | No | 1000Genomes | |
| ENSVATH05863137 | 107 | R>T | No | 1000Genomes | |
| ENSVATH02165312 | 113 | T>N | No | 1000Genomes | |
| ENSVATH05863138 | 124 | Y>F | No | 1000Genomes | |
| tmp_3_6725892_A_G | 128 | D>G | No | 1000Genomes | |
| tmp_3_6725912_G_A | 135 | D>N | No | 1000Genomes | |
| tmp_3_6725960_TGTG_T | 151 | C>* | No | 1000Genomes | |
| ENSVATH10782605 | 156 | A>S | No | 1000Genomes | |
| tmp_3_6726071_C_T | 159 | A>V | No | 1000Genomes | |
| ENSVATH05863144 | 163 | V>L | No | 1000Genomes | |
| ENSVATH05863145 | 170 | T>S | No | 1000Genomes | |
| tmp_3_6726221_A_C | 209 | N>T | No | 1000Genomes | |
| ENSVATH02165314 | 213 | E>G | No | 1000Genomes | |
| tmp_3_6726236_C_T | 214 | T>I | No | 1000Genomes | |
| ENSVATH10782606 | 215 | D>N | No | 1000Genomes | |
| tmp_3_6726244_G_T,A | 217 | D>N | No | 1000Genomes | |
| tmp_3_6726244_G_T,A | 217 | D>Y | No | 1000Genomes | |
| ENSVATH00334168 | 225 | L>F | No | 1000Genomes | |
| ENSVATH10782609 | 234 | N>I | No | 1000Genomes | |
| ENSVATH05863146 | 244 | Y>N | No | 1000Genomes | |
| tmp_3_6726505_C_T | 274 | A>V | No | 1000Genomes | |
| tmp_3_6726523_C_G | 280 | S>C | No | 1000Genomes | |
| ENSVATH00334170 | 286 | T>I | No | 1000Genomes | |
| tmp_3_6726678_G_A | 297 | V>M | No | 1000Genomes | |
| tmp_3_6726724_G_A | 312 | R>H | No | 1000Genomes | |
| tmp_3_6726767_G_C | 326 | K>N | No | 1000Genomes | |
| ENSVATH05863150 | 327 | L>F | No | 1000Genomes | |
| ENSVATH10782613 | 331 | I>T | No | 1000Genomes | |
| ENSVATH00334171 | 332 | D>A | No | 1000Genomes | |
| ENSVATH10782614 | 353 | P>L | No | 1000Genomes | |
| ENSVATH05863151 | 354 | S>L | No | 1000Genomes | |
| ENSVATH02165316 | 359 | L>F | No | 1000Genomes |
No associated diseases with Q9LT77
5 regional properties for Q9LT77
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 187 - 195 | IPR000629 |
| domain | Helicase, C-terminal | 252 - 413 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 65 - 226 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 59 - 256 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 40 - 68 | IPR014014 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proteolysis involved in protein catabolic process | The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P09668 | CTSH | Pro-cathepsin H | Homo sapiens (Human) | PR |
| O70370 | Ctss | Cathepsin S | Mus musculus (Mouse) | PR |
| P49935 | Ctsh | Pro-cathepsin H | Mus musculus (Mouse) | PR |
| P00786 | Ctsh | Pro-cathepsin H | Rattus norvegicus (Rat) | PR |
| P22895 | P34 probable thiol protease | Glycine max (Soybean) (Glycine hispida) | PR | |
| O65493 | XCP1 | Cysteine protease XCP1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94B08 | GCP1 | Germination-specific cysteine protease 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43296 | RD19A | Cysteine protease RD19A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAATPIRVIV | SALVILSVLL | LSSSLGVATE | TEIERNETEV | RLMYEQWLVE | NRKNYNGLGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KERRFKIFKD | NLKFVDEHNS | VPDRTFEVGL | TRFADLTNEE | FRAIYLRKKM | ERTKDSVKTE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RYLYKEGDVL | PDEVDWRANG | AVVSVKDQGN | CGSCWAFSAV | GAVEGINQIT | TGELISLSEQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ELVDCDRGFV | NAGCDGGIMN | YAFEFIMKNG | GIETDQDYPY | NANDLGLCNA | DKNNNTRVVT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IDGYEDVPRD | DEKSLKKAVA | HQPVSVAIEA | SSQAFQLYKS | GVMTGTCGIS | LDHGVVVVGY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GSTSGEDYWI | IRNSWGLNWG | DSGYVKLQRN | IDDPFGKCGI | AMMPSYPTKS | SFPSSFDLLS |
| EI |