O64564
Gene name |
HSP18.5 (At2g19310, F27F23.11) |
Protein name |
18.5 kDa class IV heat shock protein |
Names |
18.5 kDa heat shock protein, AtHsp18.5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G19310 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O64564
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O64564-F1 | Predicted | AlphaFoldDB |
25 variants for O64564
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05532857 | 3 | M>I | No | 1000Genomes | |
| ENSVATH01844021 | 9 | R>S | No | 1000Genomes | |
| ENSVATH05532856 | 10 | R>W | No | 1000Genomes | |
| ENSVATH05532855 | 11 | R>G | No | 1000Genomes | |
| ENSVATH01844020 | 35 | A>S | No | 1000Genomes | |
| ENSVATH14520212 | 41 | H>R | No | 1000Genomes | |
| ENSVATH13279226 | 43 | P>L | No | 1000Genomes | |
| ENSVATH01844018 | 48 | E>D | No | 1000Genomes | |
| ENSVATH01844017 | 52 | Q>P | No | 1000Genomes | |
| tmp_2_8370223_G_C | 53 | T>S | No | 1000Genomes | |
| ENSVATH13279224 | 57 | T>S | No | 1000Genomes | |
| ENSVATH05532852 | 68 | P>S | No | 1000Genomes | |
| ENSVATH05532850 | 75 | A>T | No | 1000Genomes | |
| ENSVATH00238514 | 75 | A>V | No | 1000Genomes | |
| ENSVATH00238513 | 87 | A>V | No | 1000Genomes | |
| ENSVATH05532849 | 88 | F>I | No | 1000Genomes | |
| ENSVATH13279223 | 91 | E>D | No | 1000Genomes | |
| ENSVATH13279222 | 98 | C>* | No | 1000Genomes | |
| ENSVATH01844014 | 119 | V>I | No | 1000Genomes | |
| ENSVATH00238509 | 121 | A>V | No | 1000Genomes | |
| ENSVATH00238508 | 133 | E>A | No | 1000Genomes | |
| ENSVATH14520209 | 136 | A>G | No | 1000Genomes | |
| ENSVATH05532847 | 154 | V>I | No | 1000Genomes | |
| ENSVATH13279220 | 159 | G>S | No | 1000Genomes | |
| tmp_2_8369903_C_T | 160 | D>N | No | 1000Genomes |
1 associated diseases with O64564
[MIM: 618752]: Neutropenia, severe congenital 8, autosomal dominant (SCN8)
A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. {ECO:0000269|PubMed:28972538, ECO:0000269|PubMed:29914977, ECO:0000269|PubMed:34020957}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. {ECO:0000269|PubMed:28972538, ECO:0000269|PubMed:29914977, ECO:0000269|PubMed:34020957}. Note=The disease is caused by variants affecting the gene represented in this entry.
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein self-association | Binding to a domain within the same polypeptide. |
| unfolded protein binding | Binding to an unfolded protein. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| protein complex oligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| response to hydrogen peroxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| response to salt stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P02511 | CRYAB | Alpha-crystallin B chain | Homo sapiens (Human) | PR |
| Q9UJY1 | HSPB8 | Heat shock protein beta-8 | Homo sapiens (Human) | PR |
| Q943E7 | HSP16.9C | 16.9 kDa class I heat shock protein 3 | Oryza sativa subsp japonica (Rice) | PR |
| P27777 | HSP16.9A | 16.9 kDa class I heat shock protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q943E6 | HSP16.9B | 16.9 kDa class I heat shock protein 2 | Oryza sativa subsp japonica (Rice) | PR |
| Q6K7E9 | HSP18.6 | 18.6 kDa class III heat shock protein | Oryza sativa subsp japonica (Rice) | PR |
| Q84Q77 | HSP17.9A | 17.9 kDa class I heat shock protein | Oryza sativa subsp japonica (Rice) | PR |
| P31673 | HSP17.4 | 17.4 kDa class I heat shock protein | Oryza sativa subsp japonica (Rice) | PR |
| Q84Q72 | HSP18.1 | 18.1 kDa class I heat shock protein | Oryza sativa subsp japonica (Rice) | PR |
| Q84J50 | HSP17.7 | 17.7 kDa class I heat shock protein | Oryza sativa subsp japonica (Rice) | PR |
| P30236 | HSP22.0 | 22.0 kDa class IV heat shock protein | Glycine max (Soybean) (Glycine hispida) | PR |
| O49710 | HSP15.4 | 15.4 kDa class V heat shock protein | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P19037 | HSP18.1 | 18.1 kDa class I heat shock protein | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38806 | HSP22.0 | 22.0 kDa heat shock protein | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9XIE3 | HSP17.6A | 17.6 kDa class I heat shock protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P30221 | 17.8 kDa class I heat shock protein | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSMIPISNRR | RLSPGDRIWE | PFELMNTFLD | FPSPALFLSH | HFPSLSREIF | PQTSSSTVNT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLNWTETPTA | HVFKAYLPGV | DQDEVIAFVD | EEGYLQICTG | DNKFMSRFKL | PNNALTDQVT |
| 130 | 140 | 150 | 160 | ||
| AWMEDEFLVV | FVEKDASSSP | PQLPEIEENR | NVRVVEITGD | DD |