A8WHT1
Gene name |
C53A5.17 |
Protein name |
tRNA (guanine(37)-N1)-methyltransferase |
Names |
M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5 homolog |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C53A5.17 |
EC number |
2.1.1.228: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A8WHT1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A8WHT1-F1 | Predicted | AlphaFoldDB |
No variants for A8WHT1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A8WHT1 | |||||
No associated diseases with A8WHT1
1 regional properties for A8WHT1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SAM-dependent methyltransferase TRM5/TYW2-type | 144 - 441 | IPR030382 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.228 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| tRNA (guanine(37)-N(1))-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. |
| tRNA (guanine-N1-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. |
| tRNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial tRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule. |
| tRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. |
| tRNA N1-guanine methylation | The process whereby a guanine in tRNA is methylated at position N1 of the guanine. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38793 | TRM5 | tRNA (guanine(37)-N1)-methyltransferase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| F6HH45 | VIT_11s0016g04350 | tRNA (guanine(37)-N1)-methyltransferase 2 | Vitis vinifera (Grape) | PR |
| Q5VYS8 | TUT7 | Terminal uridylyltransferase 7 | Homo sapiens (Human) | PR |
| Q32P41 | TRMT5 | tRNA (guanine(37)-N1)-methyltransferase | Homo sapiens (Human) | PR |
| Q5BLK4 | Tut7 | Terminal uridylyltransferase 7 | Mus musculus (Mouse) | PR |
| C5XX79 | Sb04g025390 | tRNA (guanine(37)-N1)-methyltransferase | Sorghum bicolor (Sorghum) (Sorghum vulgare) | PR |
| Q5XET5 | HESO1 | Protein HESO1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93YU6 | At3g56120 | tRNA (guanine(37)-N1)-methyltransferase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0VFA3 | tent2 | Poly(A) RNA polymerase GLD2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q503I9 | tent2 | Poly(A) RNA polymerase GLD2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIILKRLFSN | MSILQPPEVV | RGMTKLEKEA | FRMPVDFPVI | EIEARDAGIV | GRRVRLEPYL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IGHKLKPLKN | LVDSEKDGKK | YLVFHPDKVQ | EDETRFKILE | LLKRELGNEK | LLDWTTLSKD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LTFENWDAKS | IFKAVLPVGI | DYSSYTQTGH | IIHCNFADEI | LPFRFIIAEV | LLDKVNNCKT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVQKGNIITN | VYRNLDLELL | AGEDNYVTEV | KETGLRFKMD | FSKVYWNSRL | SHEHERVSGM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FNTQSLVYDA | CCGIGPFVLP | ATLKRKPKRV | VANDLNPESV | KWLKVNVGLN | KIKEERIEIH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NMDAKMFIKE | NVADDVVRLM | LEESTAGEFE | NEVPKPMSEV | HVVMNLPAYA | VNFLPAFRGA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSRFKDEIEK | VPLDKRYKWN | VYCYLFAKSH | VDVPDSWYED | EARRMCDEKT | KWERSLVVKC |
| 430 | 440 | 450 | 460 | 470 | |
| HNVRTVSSRK | EMFCAQLELP | YEFLLAEPFP | DEPEAQCESE | EAEEPSSKRI | KVDT |