Q5XET5

PR
Gene name
HESO1
Protein name
Protein HESO1
Names
HEN1 suppressor 1, RNA uridylyltransferase
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G39740
EC number
2.7.7.52: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

204-276 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5XET5

Entry ID Method Resolution Chain Position Source
AF-Q5XET5-F1 Predicted AlphaFoldDB

40 variants for Q5XET5

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_16576336_C_G 29 I>M No 1000Genomes
tmp_2_16576384_A_T 45 L>F No 1000Genomes
ENSVATH14599444 47 G>D No 1000Genomes
tmp_2_16576738_A_G 75 S>G No 1000Genomes
tmp_2_16576745_C_T 77 S>F No 1000Genomes
tmp_2_16576968_T_C 104 W>R No 1000Genomes
tmp_2_16576992_C_T 112 H>Y No 1000Genomes
ENSVATH01969225 150 E>K No 1000Genomes
tmp_2_16577484_C_T 211 A>V No 1000Genomes
ENSVATH01969229 232 A>S No 1000Genomes
tmp_2_16577726_A_G 260 K>E No 1000Genomes
ENSVATH05685944 321 A>T No 1000Genomes
tmp_2_16578212_C_G 348 H>Q No 1000Genomes
ENSVATH13586552 371 V>D No 1000Genomes
ENSVATH13586551 371 V>F No 1000Genomes
ENSVATH00266227 381 Q>H No 1000Genomes
ENSVATH05685945 385 M>V No 1000Genomes
tmp_2_16578325_A_G 386 Q>R No 1000Genomes
ENSVATH14599457 389 W>L No 1000Genomes
tmp_2_16578348_A_C 394 N>H No 1000Genomes
ENSVATH05685946 395 T>N No 1000Genomes
ENSVATH13586554 396 P>L No 1000Genomes
ENSVATH05685947 400 H>Y No 1000Genomes
tmp_2_16578382_C_T 405 T>I No 1000Genomes
tmp_2_16578381_A_C 405 T>P No 1000Genomes
tmp_2_16578409_C_T 414 T>I No 1000Genomes
tmp_2_16578424_G_C 419 R>T No 1000Genomes
tmp_2_16578435_G_C 423 G>R No 1000Genomes
ENSVATH00266229 428 Q>H No 1000Genomes
tmp_2_16578506_T_A 446 Y>* No 1000Genomes
tmp_2_16578510_A_T 448 S>C No 1000Genomes
tmp_2_16578520_G_A 451 R>Q No 1000Genomes
tmp_2_16578531_A_C 455 N>H No 1000Genomes
ENSVATH05685949 465 G>D No 1000Genomes
tmp_2_16578585_C_T 473 H>Y No 1000Genomes
ENSVATH14599458 483 A>T No 1000Genomes
tmp_2_16578645_C_T 493 P>S No 1000Genomes
tmp_2_16578652_C_A 495 S>* No 1000Genomes
ENSVATH05685950 502 G>E No 1000Genomes
ENSVATH13586566 509 H>Q No 1000Genomes

No associated diseases with Q5XET5

No regional properties for Q5XET5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5XET5

Functions

Description
EC Number 2.7.7.52 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, P-body
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

2 GO annotations of molecular function

Name Definition
nucleotidyltransferase activity Catalysis of the transfer of a nucleotidyl group to a reactant.
RNA uridylyltransferase activity Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1).

3 GO annotations of biological process

Name Definition
regulation of miRNA-mediated gene silencing A process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs).
RNA 3' uridylation The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule.
RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5VYS8 TUT7 Terminal uridylyltransferase 7 Homo sapiens (Human) PR
Q5BLK4 Tut7 Terminal uridylyltransferase 7 Mus musculus (Mouse) PR
A8WHT1 C53A5.17 tRNA (guanine(37)-N1)-methyltransferase Caenorhabditis elegans PR
Q0VFA3 tent2 Poly(A) RNA polymerase GLD2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q503I9 tent2 Poly(A) RNA polymerase GLD2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSRNPFLDPT LQEILQVIKP TRADRDTRIT VIDQLRDVLQ SVECLRGATV QPFGSFVSNL
70 80 90 100 110 120
FTRWGDLDIS VDLFSGSSIL FTGKKQKQTL LGHLLRALRA SGLWYKLQFV IHARVPILKV
130 140 150 160 170 180
VSGHQRISCD ISIDNLDGLL KSRFLFWISE IDGRFRDLVL LVKEWAKAHN INDSKTGTFN
190 200 210 220 230 240
SYSLSLLVIF HFQTCVPAIL PPLRVIYPKS AVDDLTGVRK TAEESIAQVT AANIARFKSE
250 260 270 280 290 300
RAKSVNRSSL SELLVSFFAK FSDINVKAQE FGVCPFTGRW ETISSNTTWL PKTYSLFVED
310 320 330 340 350 360
PFEQPVNAAR SVSRRNLDRI AQVFQITSRR LVSECNRNSI IGILTGQHIQ ESLYRTISLP
370 380 390 400 410 420
SQHHANGMHN VRNLHGQARP QNQQMQQNWS QSYNTPNPPH WPPLTQSRPQ QNWTQNNPRN
430 440 450 460 470 480
LQGQPPVQGQ TWPVITQTQT QQKSPYKSGN RPLKNTSAGS SQNQGHIGKP SGHMNGVNSA
490 500 510
RPAYTNGVNS ARPPSKIPSQ GGQIWRPRHE Q