Q5BLK4
PR
Gene name |
Tut7 |
Protein name |
Terminal uridylyltransferase 7 |
Names |
TUTase 7, Zinc finger CCHC domain-containing protein 6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:214290 |
EC number |
2.7.7.52: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5BLK4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5BLK4-F1 | Predicted | AlphaFoldDB |
No variants for Q5BLK4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5BLK4 | |||||
No associated diseases with Q5BLK4
7 regional properties for Q5BLK4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, CCHC-type | 960 - 976 | IPR001878-1 |
| domain | Zinc finger, CCHC-type | 1342 - 1358 | IPR001878-2 |
| domain | Zinc finger, CCHC-type | 1448 - 1464 | IPR001878-3 |
| domain | PAP/25A-associated | 551 - 600 | IPR002058-1 |
| domain | PAP/25A-associated | 1230 - 1282 | IPR002058-2 |
| domain | TUTase nucleotidyltransferase domain | 195 - 411 | IPR045100-1 |
| domain | TUTase nucleotidyltransferase domain | 967 - 1114 | IPR045100-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.52 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| miRNA binding | Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. |
| nucleotidyltransferase activity | Catalysis of the transfer of a nucleotidyl group to a reactant. |
| RNA uridylyltransferase activity | Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1). |
| uridylyltransferase activity | Catalysis of the transfer of an uridylyl group to an acceptor. |
| zinc ion binding | Binding to a zinc ion (Zn). |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| miRNA metabolic process | The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression. |
| negative regulation of transposition, RNA-mediated | Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate. |
| oocyte maturation | A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. |
| polyuridylation-dependent mRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA. |
| pre-miRNA processing | A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. |
| RNA 3' uridylation | The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule. |
| RNA 3'-end processing | Any process involved in forming the mature 3' end of an RNA molecule. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5VYS8 | TUT7 | Terminal uridylyltransferase 7 | Homo sapiens (Human) | PR |
| A8WHT1 | C53A5.17 | tRNA (guanine(37)-N1)-methyltransferase | Caenorhabditis elegans | PR |
| Q5XET5 | HESO1 | Protein HESO1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0VFA3 | tent2 | Poly(A) RNA polymerase GLD2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q503I9 | tent2 | Poly(A) RNA polymerase GLD2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGDTAKPYFV | KRTKDRGIID | DDDFRRGHPQ | QDYLIMDDYA | KGHSSKMEKG | LPKKKISPGN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YGNTPRKGLY | GVSSNPYAFK | NPIYSQPAWM | NDNHKDQNKK | WLSDELAGNA | DSWREFKPGP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RIPVISRSRK | ESFQESDDAY | RWQEGRGCRA | VRRLFQKDLS | SLEAMSEMEA | GSPENKKQRS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RPRKPRRTRT | EDSEQDGDLD | GPVIDESVLS | TKELLGLQQA | EERLKRDCID | RLKRRPRNCP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TAKYTCKLCD | ALIDSIPFAH | KHIKEKRHKK | NLKEKQEEEL | LTTLPPPAPS | QIHAVGSAID |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RVVQEFGLHS | ENLDQRLEIK | RVMESVFRHK | LPDCSLRLYG | SSCSRLGFRD | SDVNIDVQFP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AVMSQPDVLL | LVQECLKNSD | SFIDVDADFH | ARVPVVVCRD | KQSGLLCKVS | AGNENAWLTT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KHLTALGKLE | PRLVPLVIAF | RYWAKLCSID | RPEEGGLPPY | VFALMAVFFL | QQRKEPLLPV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YLGSWIEEFS | LNKLGNFSLK | DVEKDSVVWE | YTDNSTGDTS | SAKEEAPKET | AAKKGQVPLT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FNIKHQPSVP | VGQLWVELLR | FYALEFNLAD | LVISIRVKEL | ISRESKDWPK | KRIAIEDPYS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VKRNVARTLN | NQPVFEYILH | CLRTTYKYFA | LPHKVTKPNL | TKPPSPVTCV | SDPYREAKNG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GPEPQATNID | KLGNAAVAQD | PGVQTSGDCR | AQLVTLKNTT | EEVGSPAKEK | TGGVHIPAHQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ESSGCVQAEV | SCEGLEDATA | ELPETGSDNE | EVRRKTKHPL | STDDQGLSSS | KHPELQNCGS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LCGLQADNTL | ELVAEECNSC | ASLDNKAEVN | EERIEGAEEL | EEAAALSCFS | PSVQSRTSAA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| MHFDDEEEEE | EEEEEEEPRL | SINLTEDEEG | VANEHQVDSR | YAGSGEEDAL | SEEDDLAEPA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KGEDTGECGE | NVGGTLLIDL | NRITLKEESF | PEEDLPGDQS | EFFYEFRKLT | FTKGKSPTVV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| CSLCKREGHL | KKDCPEDFKR | VQLEPLPPLT | PKFSNILDQV | CVQCYKDFSP | TIVEDQAREH |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| IRQNLESFIK | QDFPGTKLSL | FGSSKNGFGF | KQSDLDVCMT | INGHETAEGL | DCVRTIEELA |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RVLRKHSGLR | NILPITTAKV | PIVKFFHLRS | GLEVDISLYN | TLALHNTRLL | SAYSAIDPRV |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KYLCYTMKVF | TKMCDIGDAS | RGSLSSYAYT | LMVLYFLQQR | SPPVIPVLQE | IYKGEKKPEI |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LVDGWNIYFF | DQINELPTCW | PEYGKNTEPV | GQLWLGLLRF | YTEEFDFKEH | VISIRRKSLL |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| TTFKKQWTSK | YIVIEDPFDL | NHNLGAGLSR | KMTNFIMKAF | INGRRVFGIP | VKGFPKDNPS |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| KLAYFFDPDV | LTEGELAPND | RCCRICGKIG | HFMKDCPMRR | KVRRRRDQED | TPNQRYSESK |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| EKRSKEDKEI | QNKYTEKEVS | TKEDKLTPCA | AAKAKPVRAA | VDLGREKLLR | TPTEKWKRQD |
| 1450 | 1460 | 1470 | 1480 | 1490 | |
| DRDSREKRCF | ICGREGHIKK | ECPQFKGSPG | SLSSKYMTQG | RASVKRTQQE | S |