Q0VFA3
Gene name |
tent2 (gld2, papd4) |
Protein name |
Poly(A) RNA polymerase GLD2 |
Names |
PAP-associated domain-containing protein 4 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:780377 |
EC number |
2.7.7.19: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0VFA3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0VFA3-F1 | Predicted | AlphaFoldDB |
No variants for Q0VFA3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q0VFA3 | |||||
No associated diseases with Q0VFA3
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.19 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end. |
| adenylyltransferase activity | Catalysis of the transfer of an adenylyl group to an acceptor. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| nucleotidyltransferase activity | Catalysis of the transfer of a nucleotidyl group to a reactant. |
| polynucleotide adenylyltransferase activity | Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA polyadenylation | The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. |
| negative regulation of miRNA catabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process. |
| oogenesis | The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. |
| RNA 3'-end processing | Any process involved in forming the mature 3' end of an RNA molecule. |
| RNA stabilization | Prevention of degradation of RNA molecules. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5VYS8 | TUT7 | Terminal uridylyltransferase 7 | Homo sapiens (Human) | PR |
| Q5BLK4 | Tut7 | Terminal uridylyltransferase 7 | Mus musculus (Mouse) | PR |
| A8WHT1 | C53A5.17 | tRNA (guanine(37)-N1)-methyltransferase | Caenorhabditis elegans | PR |
| Q5XET5 | HESO1 | Protein HESO1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q503I9 | tent2 | Poly(A) RNA polymerase GLD2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYPNSPSQGR | IPLPLPCEQQ | QPPLEQSQEQ | PLQPQPLQPQ | QASGYLSKLP | VSVAPELLSP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EQFIQASINL | HNNVNFARML | MNANLLAVPP | VSPPPWSYRD | QSPLISPASP | SSSFQNRKRR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SDEGNIAYDV | KRQKFQSPQE | QTVNHQAVPL | RGDLGCSYPG | SPAFPLLQSP | SPPVLKGHVP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSGECWLYDH | VDTTLPVAKD | KLSKQILELF | QALQQQVCDL | KKKDICRAEL | QREIQQIFPQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SRLYLVGSSL | NGFGTRSSDA | DLCLVLKDEP | MNQHTEARHI | LSLLHKHFYT | RLSYIERPQF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IKAKVPIVKF | RDKVSGAEFD | LNVNNVVGIR | NTFLLRTYAY | IENRVRPLVL | VIKMWANYHG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LNDASRGTLS | SYTLVLMALH | YLQTLPEPII | PSLQKKYPEC | FDSTMQLHLV | HHAPRNIPKY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSKNETPLGD | LLLGFLKYFA | IEFDWSKDII | SVREAKALPR | SDDYEWRNKF | ICVEEPYDRT |
| 490 | 500 | 510 | 520 | ||
| NTARAVYERQ | KFDMIRAEFL | RAWVALRDNR | DLYSLLPWKG | IMKKMNSL |