AiPD: Autoinhibited Protein Database

Q5VYS8

Gene name	TUT7
Protein name	Terminal uridylyltransferase 7
Names	TUTase 7, Zinc finger CCHC domain-containing protein 6
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79670
EC number	2.7.7.52: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

23-94 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

23-94 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for Q5VYS8

Entry ID	Method	Resolution	Chain	Position	Source
5W0B	X-ray	261 A	A/B/C	983-1365	PDB
5W0M	X-ray	230 A	A/B/C	983-1365	PDB
5W0N	X-ray	250 A	A/B/C	963-1365	PDB
5W0O	X-ray	249 A	A/B	983-1365	PDB
AF-Q5VYS8-F1	Predicted				AlphaFoldDB

942 variants for Q5VYS8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs779155171	1	M>?	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1162919713 CA373965774	2	G>E		No	ClinGen TOPMed
TCGA novel	3	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757461681 CA5109356	5	A>T		No	ClinGen ExAC gnomAD
CA195565930 rs145203227	10	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5109355 rs145203227	10	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142251867 CA5109354	12	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs201201332 CA5109353	12	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373965681 rs201201332	12	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	12	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5109352 rs753020716	13	T>S		No	ClinGen ExAC gnomAD
rs774587503 CA195565913	14	K>E		No	ClinGen TOPMed
rs1244526966 CA373965644	15	D>E		No	ClinGen TOPMed
rs1365365704 CA373965647	15	D>G		No	ClinGen TOPMed
CA195565889 rs753161080	16	R>Q		No	ClinGen TOPMed gnomAD
rs767133738 CA5109350	16	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1057214856 CA195565881	17	G>E		No	ClinGen TOPMed gnomAD
rs143304464 CA5109349	18	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373965605 rs1207139166	19	M>T		No	ClinGen TOPMed
CA5109347 rs751025075	19	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1482057472 CA373965580	21	D>A		No	ClinGen gnomAD
CA373965574 rs1282088250	22	D>H		No	ClinGen gnomAD
CA373965572 rs1282088250	22	D>N		No	ClinGen gnomAD
rs765841200 CA5109346	23	D>N		No	ClinGen ExAC gnomAD
rs762512323 CA5109345	24	F>C		No	ClinGen ExAC gnomAD
CA373965531 rs1241737151	24	F>L		No	ClinGen TOPMed gnomAD
rs773185841 CA5109344	25	R>G		No	ClinGen ExAC TOPMed gnomAD
CA195565862 rs2378699	25	R>K		No	ClinGen Ensembl
TCGA novel	27	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA195565861 rs143390882	27	G>S		No	ClinGen ESP TOPMed
rs927433414 CA195565860	29	P>L		No	ClinGen TOPMed
CA5109343 rs149202228	30	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs2889967 CA195565856	30	Q>H		No	ClinGen gnomAD
rs2378698 CA195565857	30	Q>P		No	ClinGen Ensembl
rs2378698 CA373965395	30	Q>R		No	ClinGen Ensembl
CA5109341 rs776319572	32	D>G		No	ClinGen ExAC TOPMed gnomAD
rs761600677 CA5109342	32	D>N		No	ClinGen ExAC TOPMed gnomAD
rs2378697 CA195565830	33	Y>F		No	ClinGen Ensembl
CA373965303 rs1359597267	34	L>*		No	ClinGen gnomAD
CA373965270 rs1322150245	35	I>M		No	ClinGen TOPMed
CA5109340 rs772370653	35	I>V		No	ClinGen ExAC TOPMed
CA373965253 rs1407110267	36	I>V		No	ClinGen TOPMed gnomAD
CA195565819 rs931556377	37	D>G		No	ClinGen TOPMed gnomAD
CA195565800 rs2378696	38	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs905498668 CA195565794	38	D>E		No	ClinGen Ensembl
rs746065141 CA5109339	38	D>N		No	ClinGen ExAC gnomAD
CA195565793 rs2378695	40	A>G		No	ClinGen 1000Genomes
CA195565792 rs2378695 VAR_053753	40	A>V		No	ClinGen UniProt 1000Genomes dbSNP
CA373965164 rs1186206491	41	K>N		No	ClinGen gnomAD
CA373965161 rs1421612307	42	G>S		No	ClinGen gnomAD
rs2378694 CA195565791	44	G>A		No	ClinGen Ensembl
rs1188145613 CA373965017	48	E>D		No	ClinGen gnomAD
CA195565786 rs2378693	48	E>K		No	ClinGen Ensembl
CA195565780 rs2378692	51	L>F		No	ClinGen Ensembl
rs1023869795 CA195565769	54	K>E		No	ClinGen Ensembl
rs369091628	54	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771131890 CA195565737	56	I>L		No	ClinGen ExAC TOPMed gnomAD
rs771131890 CA5109337	56	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1207299882 CA373964932	57	T>I		No	ClinGen gnomAD
rs2378691 CA195565732	57	T>P		No	ClinGen 1000Genomes
rs2378691 CA195565729	57	T>S		No	ClinGen 1000Genomes
CA373964922 rs1392084844	59	G>E		No	ClinGen gnomAD
TCGA novel	59	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1265432712 CA373964917	60	N>Y		No	ClinGen gnomAD
CA5109336 rs749386390	61	Y>S		No	ClinGen ExAC gnomAD
CA195565695 rs1052561423	63	N>S		No	ClinGen Ensembl
rs935474599 CA195565689	65	P>H		No	ClinGen Ensembl
CA195565687 rs2889966	66	R>K		No	ClinGen Ensembl
rs375238747 CA5109333	70	C>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs375238747 CA5109332	70	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA373964847 rs1428363799	71	A>P		No	ClinGen gnomAD
rs1338754762 CA373964845	71	A>V		No	ClinGen TOPMed gnomAD
CA373964840 rs932006399	72	V>I		No	ClinGen TOPMed gnomAD
CA195565663 rs932006399	72	V>L		No	ClinGen TOPMed gnomAD
CA373964833 rs1564107888	73	S>P		No	ClinGen Ensembl
rs1162512699 CA373964826	74	S>G		No	ClinGen gnomAD
rs755372864 CA5109331	74	S>R		No	ClinGen ExAC gnomAD
rs751203925 CA5109330	76	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs757863738 CA5109328	77	Y>H		No	ClinGen ExAC gnomAD
CA373964799 rs1260651519	78	A>S		No	ClinGen gnomAD
CA373964776 rs1588034374	81	N>T		No	ClinGen Ensembl
CA195565630 rs145331258	83	I>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA5109326 rs145331258	83	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs749904383 CA5109327	83	I>V		No	ClinGen ExAC gnomAD
CA373964757 rs1208521513	84	Y>C		No	ClinGen gnomAD
rs1267116436 CA373964760	84	Y>H		No	ClinGen gnomAD
TCGA novel	85	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373964738 rs761678664	86	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA373964732 rs1273848344	87	P>L		No	ClinGen gnomAD
CA195565622 rs941917171	88	A>T		No	ClinGen TOPMed gnomAD
TCGA novel	89	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5109323 rs763951582	89	W>C		No	ClinGen ExAC TOPMed gnomAD
CA373964716 rs1326745314	90	M>L		No	ClinGen gnomAD
CA373964698 rs1438568010	92	D>A		No	ClinGen gnomAD
rs1438568010 CA373964697	92	D>G		No	ClinGen gnomAD
rs371050255 CA5109321	93	S>T		No	ClinGen ESP ExAC gnomAD
rs749325538 CA5109319	94	H>L		No	ClinGen ExAC TOPMed gnomAD
CA5109320 rs771293279	94	H>N		No	ClinGen ExAC gnomAD
CA373964679 rs1245718284	95	K>E		No	ClinGen TOPMed gnomAD
rs150436658 CA195565595	96	D>V		No	ClinGen ESP
rs191747222 CA5109318	99	K>M		No	ClinGen 1000Genomes ExAC gnomAD
CA373964644 rs1303950079 COSM1490202	99	K>N	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs781711083 CA5109315	105	E>K		No	ClinGen ExAC gnomAD
rs1470199287 CA373964598	106	H>Y		No	ClinGen gnomAD
rs1254235921 CA373964576	109	N>S		No	ClinGen gnomAD
CA5109314 rs141619272	111	D>V		No	ClinGen ESP ExAC
rs1290648051 CA373964554	112	N>K		No	ClinGen TOPMed
rs140978834 CA5109313	112	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs186823288 CA5109312	114	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5109310 COSM287141 rs749897372	119	G>R	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA373964498 rs1344618774	120	P>R		No	ClinGen TOPMed gnomAD
rs373690069 CA195565537	121	R>G		No	ClinGen ESP TOPMed
CA373964492 rs1273996993	121	R>S		No	ClinGen gnomAD
rs1231868739 CA373964468	125	I>T		No	ClinGen gnomAD
rs764631192 CA373964453	127	R>L		No	ClinGen ExAC gnomAD
rs764631192 CA5109309	127	R>Q		No	ClinGen ExAC gnomAD
CA373964438 rs1210824615	129	R>S		No	ClinGen TOPMed
rs756832197 CA5109308	130	K>I		No	ClinGen ExAC gnomAD
CA5109307 rs753824494	130	K>N		No	ClinGen ExAC TOPMed gnomAD
CA195565505 rs1032127384	132	S>F		No	ClinGen TOPMed
rs1330333745 CA373964393	136	N>D		No	ClinGen gnomAD
CA5109306 rs764186753	136	N>K		No	ClinGen ExAC TOPMed gnomAD
rs370276327 CA5109305	138	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA195565498 rs979862289	138	D>N		No	ClinGen TOPMed gnomAD
CA373964370 rs1189160391	139	G>D		No	ClinGen TOPMed
CA5109304 rs752548118	139	G>S		No	ClinGen ExAC gnomAD
rs1588033742 CA373964344	143	Q>K		No	ClinGen Ensembl
CA373964325 rs1455900150	145	T>K		No	ClinGen gnomAD
CA373964322 rs1564107169	146	R>G		No	ClinGen Ensembl
rs766672211 CA373964313	147	G>A		No	ClinGen ExAC TOPMed gnomAD
CA5109303 rs766672211	147	G>D		No	ClinGen ExAC TOPMed gnomAD
rs969718854 CA195565471	147	G>S		No	ClinGen Ensembl
CA373964304 rs1588033653	148	C>W		No	ClinGen Ensembl
rs144572642 CA5109302	149	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs769754248 CA5109300	150	T>I		No	ClinGen ExAC gnomAD
CA5109301 rs199687338	150	T>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	151	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA195565443 rs1021238837	153	R>G		No	ClinGen TOPMed
TCGA novel	153	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5109299 rs762007355	154	L>Q		No	ClinGen ExAC gnomAD
CA373964265 rs1276842358	155	F>L		No	ClinGen gnomAD
rs777061932 CA5109298	156	H>R		No	ClinGen ExAC gnomAD
CA373964246 rs1588033525	158	D>A		No	ClinGen Ensembl
rs1280799744 CA373964247	158	D>H		No	ClinGen gnomAD
CA195565409 rs966948420	159	L>V		No	ClinGen TOPMed gnomAD
CA5109296 rs201566816	160	T>I		No	ClinGen ExAC TOPMed gnomAD
rs201566816 COSM3780173 CA373964233	160	T>R	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5109295 rs142341283	161	S>C		No	ClinGen ESP ExAC gnomAD
rs1031189976 CA195565389	161	S>N		No	ClinGen Ensembl
rs745478644 CA5109294	162	L>I		No	ClinGen ExAC TOPMed gnomAD
CA373964224 rs1339498384	162	L>P		No	ClinGen TOPMed gnomAD
CA373964222 rs1219910861	163	E>Q		No	ClinGen TOPMed
COSM753969 CA195565321 rs1020835849	165	T>M	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA373964186 rs1465436619	168	M>K		No	ClinGen Ensembl
CA373963921 rs1588015323	174	E>V		No	ClinGen Ensembl
rs151232839 CA5109255	175	N>K		No	ClinGen ESP ExAC TOPMed
CA5109254 rs774811677	176	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA373963872 rs1430542061	181	R>K		No	ClinGen gnomAD
rs1186926017 CA373963851	184	K>T		No	ClinGen gnomAD
rs1353741708 CA373963845	185	P>T		No	ClinGen TOPMed
CA5109252 rs201715276	186	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5109253 rs370301209	186	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1215013588 CA373963832	187	K>M		No	ClinGen gnomAD
rs61747122 RCV000965109 CA5109249	188	T>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5109251 rs773043739	188	T>S		No	ClinGen ExAC
rs61747122 CA5109250	188	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373963826 rs1280824907	189	R>G		No	ClinGen TOPMed
rs1250282994 CA15602817	190	N>S		No	ClinGen TOPMed gnomAD
rs1253827556 CA373963812	191	E>K		No	ClinGen gnomAD
CA5109248 rs780921499	192	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5109247 rs371940964	201	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs375488484 CA5109245	205	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1048638948 CA195560806	206	E>D		No	ClinGen TOPMed
rs1399574621 CA373963697	207	S>P		No	ClinGen TOPMed gnomAD
CA373963692 rs1253448307	208	V>I		No	ClinGen TOPMed
rs573749109 CA195560775	211	T>A		No	ClinGen Ensembl
rs754054941 CA5109243	211	T>M		No	ClinGen ExAC gnomAD
CA373963664 rs1170863673	212	K>N		No	ClinGen gnomAD
rs777924923 CA373963656	213	E>D		No	ClinGen ExAC gnomAD
rs941790084 CA195560726	213	E>K		No	ClinGen Ensembl
rs983094223 CA195560706	217	L>S		No	ClinGen Ensembl
CA5109239 rs767872713	218	Q>E		No	ClinGen ExAC gnomAD
rs202080089 CA5109238	219	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1454674483 CA373963617	220	A>S		No	ClinGen TOPMed gnomAD
CA373963619 rs1454674483	220	A>T		No	ClinGen TOPMed gnomAD
rs766822670 CA5109236	222	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	225	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375411108 CA5109233	226	R>T	Variant assessed as Somatic; 4.626e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs192099334 CA5109231	227	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768097673 CA5109230	229	I>T		No	ClinGen ExAC gnomAD
TCGA novel	231	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771841351 CA5109227	234	R>M		No	ClinGen ExAC TOPMed gnomAD
rs776184649 CA5109213	235	R>P		No	ClinGen ExAC TOPMed gnomAD
CA195560223 COSM287565 rs776184649	235	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1157805468 CA373963495	236	P>L		No	ClinGen gnomAD
rs139153052 CA5109212	237	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA5109211 rs529751930	238	N>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA373963474 rs1167701091	240	P>A		No	ClinGen TOPMed
CA5109209 rs772010962	240	P>L		No	ClinGen ExAC gnomAD
TCGA novel	241	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1394707353 CA373963466	241	T>I		No	ClinGen TOPMed
CA5109208 rs745612057	241	T>P		No	ClinGen ExAC gnomAD
rs1363825302 CA373963446	244	Y>F		No	ClinGen gnomAD
rs1411885801 CA373963429	247	R>G		No	ClinGen TOPMed
rs377220747 CA195560171	248	L>F		No	ClinGen ESP gnomAD
rs377220747 CA373963421	248	L>V		No	ClinGen ESP gnomAD
CA5109205 rs748376571	250	D>N		No	ClinGen ExAC TOPMed gnomAD
rs781323313 CA5109204	250	D>V		No	ClinGen ExAC gnomAD
CA373963399 rs755077966	251	V>A		No	ClinGen ExAC gnomAD
CA5109203 rs755077966	251	V>D		No	ClinGen ExAC gnomAD
CA195560146 rs1006079147	256	I>T		No	ClinGen Ensembl
CA373963359 rs1365160653	256	I>V		No	ClinGen TOPMed
CA5109202 rs751608191	257	A>V		No	ClinGen ExAC gnomAD
TCGA novel	259	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	259	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA195560132 rs988777004	260	H>R		No	ClinGen TOPMed gnomAD
TCGA novel	261	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5109201 rs780661622	263	I>M		No	ClinGen ExAC TOPMed gnomAD
rs756079105 CA195560115	263	I>V		No	ClinGen Ensembl
CA5109200 rs759007947	267	R>G		No	ClinGen ExAC gnomAD
CA5109199 rs751009735	268	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA195560107 rs1047504972	269	K>E		No	ClinGen TOPMed
rs1588012354 CA373963158	270	K>I		No	ClinGen Ensembl
rs1294211562 CA373963145	271	N>S		No	ClinGen TOPMed gnomAD
CA373963139 rs1341161992	272	I>V		No	ClinGen TOPMed
TCGA novel	274	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA195559756 rs763655153	275	K>E		No	ClinGen Ensembl
CA5109184 rs768786445	277	E>K		No	ClinGen ExAC gnomAD
CA5109183 rs747049274	283	T>M		No	ClinGen ExAC gnomAD
rs758602115 CA5109181	284	L>S		No	ClinGen ExAC gnomAD
CA373962898 rs1438640659	286	P>L		No	ClinGen gnomAD
CA373962892 rs1198765083	287	P>A		No	ClinGen TOPMed
rs1427189763 CA373962889	287	P>Q		No	ClinGen TOPMed
CA373962894 rs1198765083	287	P>T		No	ClinGen TOPMed
rs1323678948 CA373962882	288	T>A		No	ClinGen gnomAD
CA5109180 rs78187627	288	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373962873 rs1588010551	289	P>A		No	ClinGen Ensembl
CA373962865 rs1176534324	289	P>L		No	ClinGen TOPMed
CA373962843 rs757575568	291	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs763753780 CA5109176	296	G>A		No	ClinGen ExAC gnomAD
CA195559668 rs948452921	296	G>C		No	ClinGen Ensembl
CA373962752 rs1300738991	299	I>V		No	ClinGen TOPMed
rs1366117592 CA373962732	300	D>A		No	ClinGen TOPMed
CA5109175 rs371329327	301	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	302	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373962699 rs1302433956	303	V>L		No	ClinGen TOPMed
CA5109174 rs752386065	305	E>G		No	ClinGen ExAC TOPMed gnomAD
rs903570419 CA195559667	305	E>K		No	ClinGen TOPMed
TCGA novel	307	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs914214054 CA195559651	309	H>P		No	ClinGen TOPMed
CA5109172 rs759102298	310	N>S		No	ClinGen ExAC TOPMed gnomAD
CA373962601 rs1289053596	312	N>H		No	ClinGen gnomAD
rs1221933903 CA373962543	315	Q>R		No	ClinGen TOPMed
rs1377583136 CA373962506	318	E>G		No	ClinGen gnomAD
TCGA novel	318	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	320	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766227229 CA5109170	321	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs762764983 CA5109169	321	R>H		No	ClinGen ExAC TOPMed gnomAD
CA5109168 rs772915611	322	I>L		No	ClinGen ExAC gnomAD
CA373962445 rs1373149418	323	M>V		No	ClinGen gnomAD
CA5109167 rs563321567	325	N>D		No	ClinGen ExAC gnomAD
CA5109164 rs772276191	326	V>A		No	ClinGen ExAC gnomAD
rs150701408 CA5109165	326	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150701408 CA5109166	326	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373962414 rs1330397024	327	F>C		No	ClinGen gnomAD
CA373962391 rs1426563876	329	H>P		No	ClinGen TOPMed
rs35653710 CA195558312	334	C>W		No	ClinGen Ensembl
CA195558319 rs141994664	334	C>Y		No	ClinGen ESP TOPMed gnomAD
rs772437076 CA5109142	339	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs761197701 CA5109141	343	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs112306304 CA5109140	345	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199887046 CA5109137 CA5109138	348	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs202154191 CA5109136	349	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5109135 rs748513865	349	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	350	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373961878 rs1312884523	356	D>Y		No	ClinGen TOPMed
CA373961848 rs1445245185	358	Q>R		No	ClinGen TOPMed gnomAD
rs751269496 CA5109132	362	I>T		No	ClinGen ExAC TOPMed gnomAD
rs374368241 CA5109133	362	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA373960543 rs1367971547	363	M>L		No	ClinGen gnomAD
CA195556802 rs753003062	365	Q>H		No	ClinGen TOPMed
TCGA novel	370	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373960321 rs1229257977	372	V>L		No	ClinGen TOPMed gnomAD
TCGA novel	374	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA195556796 rs765354660	375	C>R		No	ClinGen Ensembl
rs757292298 CA5109107	381	S>C		No	ClinGen ExAC TOPMed gnomAD
rs757292298 CA5109108	381	S>F		No	ClinGen ExAC TOPMed gnomAD
CA5109106 rs753865676	382	F>V		No	ClinGen ExAC TOPMed gnomAD
CA5109105 rs763959648	384	D>G		No	ClinGen ExAC gnomAD
rs763959648 CA373959886	384	D>V		No	ClinGen ExAC gnomAD
CA373959828 rs940058115	387	A>G		No	ClinGen gnomAD
rs940058115 CA195555990	387	A>V		No	ClinGen gnomAD
CA5109104 rs760574434	388	D>Y		No	ClinGen ExAC gnomAD
rs751724559 CA5109103	389	F>L		No	ClinGen ExAC gnomAD
TCGA novel	389	F>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1444662625 CA373959777	390	H>R		No	ClinGen gnomAD
CA373959739 rs1564090083	392	R>S		No	ClinGen Ensembl
rs143742419 CA5109102	395	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs75302229 CA195555980	398	C>F		No	ClinGen Ensembl
CA5109099 rs765344339	400	E>D		No	ClinGen ExAC gnomAD
CA373959575 rs1160518689	402	Q>R		No	ClinGen TOPMed
rs890292000 CA195555122	403	S>R		No	ClinGen Ensembl
rs576476359 CA5109072	406	L>R		No	ClinGen 1000Genomes ExAC gnomAD
rs931739817 CA373959270	411	A>S		No	ClinGen TOPMed gnomAD
CA195555100 COSM422324 rs931739817	411	A>T	urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
TCGA novel	412	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5109070 rs369631683	413	N>S		No	ClinGen ESP ExAC gnomAD
rs11999128 CA5109067	417	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA5109066 rs747853622	420	T>A		No	ClinGen ExAC gnomAD
TCGA novel	421	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5109063 rs750641324	428	K>R		No	ClinGen ExAC gnomAD
rs941680544 CA373958900	434	V>F		No	ClinGen TOPMed gnomAD
rs941680544 CA195555006	434	V>I		No	ClinGen TOPMed gnomAD
rs200349326 CA5109061	436	L>F		No	ClinGen ExAC gnomAD
CA195554993 rs866068989	437	V>L		No	ClinGen Ensembl
rs764467993 CA5109059	438	I>T		No	ClinGen ExAC TOPMed gnomAD
CA5109060 rs753939459	438	I>V		No	ClinGen ExAC gnomAD
rs753192584 CA5109057	442	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs753192584 CA373958726	442	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA373958665 rs1403220001	444	A>S		No	ClinGen gnomAD
rs762659792 CA373957744	448	S>C		No	ClinGen ExAC gnomAD
rs762659792 CA5109035	448	S>G		No	ClinGen ExAC gnomAD
rs919113809 CA195552310	448	S>N		No	ClinGen Ensembl
CA5109034 rs772785457	449	I>V		No	ClinGen ExAC gnomAD
rs1564086237 CA373957713	450	D>A		No	ClinGen Ensembl
rs377283750 CA5109033	451	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs778107333 CA5109032	451	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs778107333 CA5109031	451	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1279606200 CA373957625	455	G>R		No	ClinGen gnomAD
TCGA novel	456	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373957602 rs1217394605	457	L>V		No	ClinGen gnomAD
TCGA novel	460	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs868372493 CA195552298	463	A>V		No	ClinGen Ensembl
rs1237917174 COSM4139638 CA373957262	472	Q>R	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1182363589 CA373957198	475	E>V		No	ClinGen TOPMed
CA5109026 rs749497606	476	P>A		No	ClinGen ExAC gnomAD
CA5109025 rs777923164	476	P>L		No	ClinGen ExAC TOPMed gnomAD
rs749497606 CA5109027	476	P>S		No	ClinGen ExAC gnomAD
rs752730875 CA5109023	479	P>A		No	ClinGen ExAC gnomAD
rs1158323522 CA373957141	480	V>A		No	ClinGen TOPMed
rs1473359590 CA373957148	480	V>I		No	ClinGen TOPMed
rs1416630000 CA373957130	481	Y>C		No	ClinGen gnomAD
TCGA novel	481	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373957122 rs1426004675	482	L>I		No	ClinGen gnomAD
TCGA novel	488	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769929887 CA5109004	489	F>L		No	ClinGen ExAC gnomAD
rs748215037 CA5109003	491	L>V		No	ClinGen ExAC gnomAD
CA5109002 rs781385125	492	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5109000 rs747501311	493	K>N		No	ClinGen ExAC
CA5109001 rs755155326	493	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA373956414 rs1187846140	496	N>S		No	ClinGen gnomAD
rs750779168 CA5108997	496	N>Y		No	ClinGen ExAC TOPMed gnomAD
CA5108996 rs756829339	498	N>K		No	ClinGen ExAC gnomAD
CA373956398 rs1345332911	498	N>S		No	ClinGen TOPMed
CA373956385 rs1269451184	500	Q>R		No	ClinGen gnomAD
rs763582765 CA5108993	503	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs760244645 CA5108992	510	E>Q		No	ClinGen ExAC gnomAD
rs878978126 CA195546912	511	H>D		No	ClinGen Ensembl
CA373956300 rs1213606369	512	T>A		No	ClinGen TOPMed
rs1230324728 CA373956298	512	T>N		No	ClinGen gnomAD
rs767455747 CA5108990	513	D>E		No	ClinGen ExAC gnomAD
CA5108989 rs560704303	514	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA5108987 rs770796065	516	A>P		No	ClinGen ExAC TOPMed gnomAD
CA5108988 rs770796065	516	A>S		No	ClinGen ExAC TOPMed gnomAD
rs748293741 CA5108986	517	G>R		No	ClinGen ExAC gnomAD
rs377765400 CA5108985	518	D>H		No	ClinGen ESP ExAC gnomAD
rs768792867 CA5108984	519	T>R		No	ClinGen ExAC TOPMed gnomAD
rs892757541 CA195546881	520	G>A		No	ClinGen TOPMed
CA195546874 rs765657868	521	I>V		No	ClinGen Ensembl
rs1197764054 CA373956192	523	K>E		No	ClinGen TOPMed
CA5108983 rs747102334	524	E>K		No	ClinGen ExAC gnomAD
rs1406941439	525	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs780663287 CA5108982	527	P>A		No	ClinGen ExAC
CA5108981 rs373205612	527	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs199585068 CA5108980	528	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA373956065 rs1478531780	530	T>A		No	ClinGen TOPMed
CA5108978 rs146532116	530	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA5108976 rs149486999	531	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs149486999 CA5108977	531	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs544962008 CA5108974	534	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs544962008 CA373955945	534	R>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376187706 CA5108973	536	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs530912952 CA5108972	536	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1287499801 CA373954642	540	I>M		No	ClinGen TOPMed gnomAD
CA5108956 rs755793691	540	I>R		No	ClinGen ExAC gnomAD
rs780541304 CA5108954	541	L>V		No	ClinGen ExAC gnomAD
CA195545706 rs75677091	543	V>L		No	ClinGen gnomAD
CA373954615 rs75677091	543	V>M		No	ClinGen gnomAD
CA5108953 rs754572213	544	K>T		No	ClinGen ExAC gnomAD
CA373954580 rs1212937236	545	H>Q		No	ClinGen TOPMed
rs949002468 CA195545705	545	H>R		No	ClinGen Ensembl
rs1465459680 CA373954578	546	Q>E		No	ClinGen gnomAD
rs751443994 CA5108952	547	P>L		No	ClinGen ExAC TOPMed gnomAD
CA5108951 rs766356764	548	S>P		No	ClinGen ExAC TOPMed gnomAD
rs762610101 CA5108950	549	V>L		No	ClinGen ExAC TOPMed gnomAD
rs750278805 CA5108949	551	V>F		No	ClinGen ExAC gnomAD
CA373954488 rs1409834587	553	Q>R		No	ClinGen gnomAD
rs113877876 CA195545692	556	V>A		No	ClinGen Ensembl
rs41310053 CA5108945	560	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs759667515 CA5108944	562	Y>N		No	ClinGen ExAC gnomAD
CA373954202 rs1375457461	570	D>Y		No	ClinGen TOPMed
CA5108942 rs771489134	574	S>R		No	ClinGen ExAC TOPMed gnomAD
CA373954102 rs1210829754	575	I>V		No	ClinGen gnomAD
CA373954066 rs1328581115	576	R>H		No	ClinGen gnomAD
CA5108941 rs749613140	578	K>N		No	ClinGen ExAC gnomAD
TCGA novel	579	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778080084 CA5108940	580	L>S		No	ClinGen ExAC gnomAD
rs1352142027 CA373953985	581	V>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs770189931 CA5108939	582	S>P		No	ClinGen ExAC gnomAD
CA5108938 rs747781651	583	R>Q		No	ClinGen ExAC gnomAD
rs200763713 CA195545662	585	L>S		No	ClinGen Ensembl
CA195545646 rs892024505	590	K>R		No	ClinGen TOPMed
rs754376979 CA5108936	592	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs779817903 CA5108934	595	I>T		No	ClinGen ExAC gnomAD
rs1296783181 CA373953657	595	I>V		No	ClinGen TOPMed
rs1338428003 CA373953221	600	S>C		No	ClinGen TOPMed
rs369824696 CA5108906	609	L>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs778999776 CA5108904	613	P>A		No	ClinGen ExAC gnomAD
rs778999776 CA373952934	613	P>S		No	ClinGen ExAC gnomAD
rs375541478 CA5108903	615	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5108902 rs149751959	618	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5108901 rs149751959	618	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	625	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751777677 CA373952602	627	K>E		No	ClinGen ExAC TOPMed gnomAD
rs751777677 CA5108899	627	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA195544979 rs1046754319	633	H>D		No	ClinGen Ensembl
CA5108894 rs762127904	634	K>E		No	ClinGen ExAC gnomAD
rs762127904 CA5108895	634	K>Q		No	ClinGen ExAC gnomAD
rs777026458 CA5108893	634	K>R		No	ClinGen ExAC gnomAD
rs768953994 CA5108892	636	T>I		No	ClinGen ExAC gnomAD
CA5108891 rs150985653	639	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs771642859 CA5108889	642	K>M		No	ClinGen ExAC gnomAD
CA373952286 rs1384687918	642	K>N		No	ClinGen gnomAD
rs199527404 CA5108890	642	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs745387000 CA5108888	645	N>K		No	ClinGen ExAC
CA5108886 rs372250530	646	A>V		No	ClinGen ESP ExAC gnomAD
CA373952196 rs1386597552	648	T>A		No	ClinGen TOPMed gnomAD
CA195544941 rs1023132869	648	T>I		No	ClinGen TOPMed
rs1386597552 CA373952200	648	T>P		No	ClinGen TOPMed gnomAD
CA373952166 rs1429690767	649	C>G		No	ClinGen gnomAD
CA373952144 rs1318138860	650	I>N		No	ClinGen TOPMed
rs1318138860 CA373952142	650	I>T		No	ClinGen TOPMed
CA5108883 rs560186330	653	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs749223528 CA5108884	653	H>Y		No	ClinGen ExAC gnomAD
CA5108882 rs376742250	656	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA373952033 rs1454783939	656	E>D		No	ClinGen gnomAD
rs1017036268 CA195544929	657	V>I		No	ClinGen TOPMed
rs1368359022 CA373952013	658	I>V		No	ClinGen gnomAD
CA5108881 rs751797750	663	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA373951854 rs1197072793	665	Q>R		No	ClinGen gnomAD
CA5108880 rs61730257	666	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA195544901 rs951148608	667	K>E		No	ClinGen TOPMed
CA195544896 rs750182955	668	D>E		No	ClinGen ExAC gnomAD
rs750535574 CA5108878	669	D>G		No	ClinGen ExAC TOPMed gnomAD
CA373951786 rs1222872319	669	D>H		No	ClinGen gnomAD
rs765344226 CA5108877	670	K>E		No	ClinGen ExAC gnomAD
CA373951763 rs1164394302	670	K>T		No	ClinGen TOPMed
rs762362699 CA5108876	671	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	672	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs118052854 CA5108875	673	N>H		No	ClinGen 1000Genomes ExAC gnomAD
CA373951641 rs1587941110	676	L>F		No	ClinGen Ensembl
rs764516147 CA5108874	676	L>W		No	ClinGen ExAC gnomAD
rs193087051 CA195544886	677	A>V		No	ClinGen 1000Genomes TOPMed gnomAD
CA195544880 rs372076741	679	G>R		No	ClinGen ESP
CA373951585 rs1409673791	680	P>L		No	ClinGen gnomAD
CA373951551 rs767584897	684	S>G		No	ClinGen gnomAD
CA5108873 rs760952752	684	S>I		No	ClinGen ExAC gnomAD
rs767584897 CA195544877	684	S>R		No	ClinGen gnomAD
rs775227185 CA5108872	686	A>P		No	ClinGen ExAC gnomAD
CA195544872 rs997888763	688	N>D		No	ClinGen TOPMed gnomAD
CA5108870 rs188666254	690	C>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1297487272 CA373951311	691	K>R		No	ClinGen TOPMed
rs773966263 CA5108869	692	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1232307502 CA373951220	695	L>F		No	ClinGen TOPMed
CA5108868 rs770612785	696	T>N		No	ClinGen ExAC gnomAD
CA5108867 rs749235332	697	L>V		No	ClinGen ExAC gnomAD
TCGA novel	699	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777634187 CA5108866	700	T>I		No	ClinGen ExAC TOPMed gnomAD
rs777634187 CA373951112	700	T>S		No	ClinGen ExAC TOPMed gnomAD
CA373951094 rs1472172130	701	A>G		No	ClinGen gnomAD
rs747906637 CA5108864	702	E>A		No	ClinGen ExAC TOPMed gnomAD
CA373951063 rs1438278549	703	S>G		No	ClinGen gnomAD
CA373951048 rs1277316233	703	S>R		No	ClinGen TOPMed gnomAD
CA373951026 rs1198161562	704	F>C		No	ClinGen gnomAD
CA5108862 rs758591070	710	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	714	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373950808 rs1349061931	716	H>Y		No	ClinGen gnomAD
rs1018490496 CA195544793	718	S>I		No	ClinGen Ensembl
TCGA novel	718	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA195544795 rs964278797	718	S>R		No	ClinGen Ensembl
CA373950765 rs1332275311	719	V>I		No	ClinGen gnomAD
rs1485816752 CA373950742	720	H>Q		No	ClinGen TOPMed
CA5108859 rs757350270	721	P>S		No	ClinGen ExAC TOPMed gnomAD
rs754305044 CA5108858	722	E>K		No	ClinGen ExAC gnomAD
CA5108857 rs143252253	724	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1178667021 CA373950674 CA373950675	725	D>E		No	ClinGen gnomAD
CA589123149 rs1409520730	725	D>V		No	ClinGen gnomAD
rs1488786660 CA373950635	728	Q>P		No	ClinGen TOPMed
CA195544774 rs1005722206	730	D>A		No	ClinGen Ensembl
rs1470474774 CA373950591	731	V>D		No	ClinGen TOPMed gnomAD
rs61744147 CA5108854	737	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs934612334 CA195544767	741	V>I		No	ClinGen TOPMed
CA5108853 rs759241641	742	Y>F		No	ClinGen ExAC gnomAD
CA373950441 rs1462304593	742	Y>H		No	ClinGen gnomAD
rs770466734 CA373950402	744	P>L		No	ClinGen ExAC TOPMed gnomAD
CA5108851 rs770466734	744	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA5108849 rs773140978	745	E>G		No	ClinGen ExAC gnomAD
CA5108850 rs762371432	745	E>K		No	ClinGen ExAC TOPMed gnomAD
CA5108848 rs769638972	746	T>A		No	ClinGen ExAC TOPMed gnomAD
CA373950343 rs1361414375	749	K>E		No	ClinGen TOPMed gnomAD
TCGA novel	750	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768500733 CA5108845	751	E>A		No	ClinGen ExAC TOPMed gnomAD
rs776390996 CA5108846	751	E>K		No	ClinGen ExAC gnomAD
rs576337306 CA5108844	752	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	753	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373950251 rs1356943982	759	G>D		No	ClinGen TOPMed
CA373950238 rs1228448033	761	H>Y		No	ClinGen TOPMed
TCGA novel	764	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5108839 rs778305965	766	D>N		No	ClinGen ExAC gnomAD
CA5108838 rs756545766	767	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA5108837 rs753304576	769	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5108836 rs767979913	769	R>H		No	ClinGen ExAC gnomAD
rs1243553679 CA373950182	770	G>R		No	ClinGen gnomAD
CA5108834 rs751186781	771	E>D		No	ClinGen ExAC gnomAD
CA373950173 rs1451437826	771	E>G		No	ClinGen gnomAD
CA5108835 rs755460109	771	E>K		No	ClinGen ExAC TOPMed gnomAD
rs776808343 CA195544665	772	H>L		No	ClinGen ExAC gnomAD
rs776808343 CA5108833	772	H>P		No	ClinGen ExAC gnomAD
rs762472970 CA5108832	772	H>Q		No	ClinGen ExAC gnomAD
rs776808343 CA373950167	772	H>R		No	ClinGen ExAC gnomAD
rs761801797 CA195544647	774	V>F		No	ClinGen Ensembl
CA373950151 rs916094979	775	C>S		No	ClinGen TOPMed gnomAD
rs916094979 CA195544643	775	C>Y		No	ClinGen TOPMed gnomAD
rs556235880 CA373950135 CA5108831	777	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs764854115 CA5108830	778	T>P		No	ClinGen ExAC TOPMed gnomAD
COSM1110768 CA5108829 rs761728890	779	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5108828 rs375726501	779	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5108827 rs143857116	780	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs982421973 CA195544618	787	L>W		No	ClinGen TOPMed gnomAD
CA5108825 rs774584682	789	L>S		No	ClinGen ExAC gnomAD
CA195544612 rs951090639	790	E>G		No	ClinGen TOPMed
rs749563275 CA5108823	791	G>A		No	ClinGen ExAC gnomAD
TCGA novel	791	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA195544609 rs948000856	792	F>L		No	ClinGen gnomAD
rs1390660170 CA373950007	797	A>T		No	ClinGen gnomAD
TCGA novel	797	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1186778073 CA373949997	798	K>E		No	ClinGen gnomAD
TCGA novel	799	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777691353 CA5108822	800	C>R		No	ClinGen ExAC TOPMed gnomAD
rs1380804842 CA373949919	803	L>P		No	ClinGen TOPMed
CA373949908 rs1225104569	804	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5108821 rs149644302	806	L>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA195544591 rs781764595	807	D>H		No	ClinGen ExAC TOPMed gnomAD
CA5108819 rs781764595	807	D>N		No	ClinGen ExAC TOPMed gnomAD
CA5108820 rs781764595	807	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs371448305 CA5108818 CA373949857	808	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	808	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1309378638 CA373949849	809	K>T		No	ClinGen gnomAD
rs1296336068 CA373949831	810	A>G		No	ClinGen gnomAD
rs751992086 CA5108817	811	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA373949812 rs1297204331	812	L>I		No	ClinGen TOPMed
rs1018541613 CA195544576	812	L>R		No	ClinGen TOPMed gnomAD
rs766013413 CA5108816	813	D>G		No	ClinGen ExAC gnomAD
rs757967439 CA5108815	814	G>E		No	ClinGen ExAC gnomAD
TCGA novel	817	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373949738 rs1406609969	817	T>I		No	ClinGen gnomAD
CA5108814 rs750150701	818	E>V		No	ClinGen ExAC gnomAD
rs556349133 CA5108812	819	G>D		No	ClinGen ExAC TOPMed gnomAD
rs368747887 CA5108813	819	G>S		No	ClinGen ESP ExAC gnomAD
CA373949713 rs556349133	819	G>V		No	ClinGen ExAC TOPMed gnomAD
rs768097210 CA373949712	820	T>A		No	ClinGen TOPMed gnomAD
CA195544557 rs768097210	820	T>P		No	ClinGen TOPMed gnomAD
rs764044754 CA5108810	821	E>G		No	ClinGen ExAC gnomAD
CA373949679 rs1422705600	823	L>P		No	ClinGen gnomAD
rs775118718 CA5108808	825	D>G		No	ClinGen ExAC gnomAD
CA5108809 rs202050130	825	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA373949658 rs1278641280	826	S>F		No	ClinGen TOPMed
CA5108806 rs763069281	829	H>Y		No	ClinGen ExAC gnomAD
CA373949625 rs1251978084	831	T>S		No	ClinGen gnomAD
CA5108803 rs748251283	832	H>Q		No	ClinGen ExAC gnomAD
CA5108804 rs769924592	832	H>R		No	ClinGen ExAC gnomAD
CA5108802 rs781745650	835	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA5108801 rs769316272	836	G>D		No	ClinGen ExAC TOPMed gnomAD
rs769316272 CA373949594	836	G>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	841	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373949563 rs1287435130	841	M>V		No	ClinGen gnomAD
CA5108800 rs747589523	844	S>A		No	ClinGen ExAC gnomAD
rs1375359704 CA373949530	846	E>K		No	ClinGen gnomAD
rs147535547 CA5108797	849	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1356909670 CA373949503	849	E>G		No	ClinGen gnomAD
CA195544497 rs923770254	849	E>K		No	ClinGen Ensembl
RCV000901250 rs139212809 CA5108794	851	D>N		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs915975237 CA195544450	852	E>A		No	ClinGen TOPMed
CA373949480 rs1421403079	852	E>D		No	ClinGen gnomAD
rs1157322504 CA373949485	852	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA195544447 rs191736673	854	E>V		No	ClinGen 1000Genomes gnomAD
rs1181775354 CA373949460	855	E>A		No	ClinGen TOPMed gnomAD
rs1181775354 CA373949458	855	E>V		No	ClinGen TOPMed gnomAD
rs1369528075 CA373949428	859	E>A		No	ClinGen TOPMed
CA373949430 rs1331459283	859	E>Q		No	ClinGen TOPMed
rs371362648 CA5108789	860	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371362648 CA373949419	860	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1301815167 CA373949415	861	R>T		No	ClinGen TOPMed
CA373949409 rs1204574963	862	L>F		No	ClinGen gnomAD
rs1370240552 CA373949408	862	L>P		No	ClinGen TOPMed
CA373949395 rs1267267779	864	I>M		No	ClinGen gnomAD
CA195544429 rs983028825	864	I>T		No	ClinGen TOPMed
rs781492162 CA195544436	864	I>V		No	ClinGen gnomAD
CA5108788 rs370511325	865	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1200692884 CA373949376	867	R>K		No	ClinGen TOPMed
CA373949372 rs1258795873	868	E>K		No	ClinGen TOPMed
rs1468055509 CA373949348	871	D>N		No	ClinGen TOPMed
CA373949331 rs1211798221	873	M>T		No	ClinGen TOPMed
CA5108787 rs200304124	873	M>V		No	ClinGen 1000Genomes ExAC gnomAD
CA5108786 rs752735259	874	A>D		No	ClinGen ExAC
CA195544402 rs376190058	875	N>D		No	ClinGen ESP TOPMed gnomAD
CA373949320 rs376190058	875	N>H		No	ClinGen ESP TOPMed gnomAD
rs1478273989 CA373949297	878	E>Q		No	ClinGen TOPMed
CA373949276 rs1587938203	880	D>E		No	ClinGen Ensembl
TCGA novel	882	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs953004337 CA195544393	883	Y>H		No	ClinGen Ensembl
CA5108783 rs773250617	884	T>P		No	ClinGen ExAC gnomAD
CA373949234 rs1387370224	887	G>E		No	ClinGen gnomAD
CA373949232 rs1387370224	887	G>V		No	ClinGen gnomAD
rs770162712 CA5108782	888	D>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	890	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776819297 CA5108780	890	D>V		No	ClinGen ExAC gnomAD
CA5108781 rs761943014	890	D>Y		No	ClinGen ExAC gnomAD
CA373949207 rs1387179481	891	A>G		No	ClinGen gnomAD
CA195544343 rs879758874	891	A>T		No	ClinGen TOPMed gnomAD
CA373949205 rs1464499747	892	L>V		No	ClinGen TOPMed gnomAD
CA373949199 rs1207097713	893	S>P		No	ClinGen gnomAD
rs1261054340 CA373949185	895	E>K		No	ClinGen gnomAD
CA373949181 rs1352116791	895	E>V		No	ClinGen TOPMed
TCGA novel	898	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	898	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5108777 rs772267345	900	G>A		No	ClinGen ExAC TOPMed gnomAD
COSM1463432 CA5108776 rs772267345	900	G>D	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs756875035 CA5108773	901	E>K		No	ClinGen ExAC TOPMed gnomAD
CA373949132 rs747555350	902	A>G		No	ClinGen TOPMed gnomAD
CA195544268 rs747555350	902	A>V		No	ClinGen TOPMed gnomAD
rs753541405 CA5108772	905	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	906	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs139228339 CA5108770	908	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA195544231 rs758466847	909	K>E		No	ClinGen Ensembl
TCGA novel	910	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752505984 CA5108769	914	H>P		No	ClinGen ExAC gnomAD
rs754679699 CA5108767	914	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA5108765 rs552232426	920	L>P		No	ClinGen 1000Genomes ExAC gnomAD
rs762102469 CA5108764	922	E>D		No	ClinGen ExAC gnomAD
TCGA novel	924	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1017988349 CA5108762	926	I>T		No	ClinGen TOPMed gnomAD
rs764204995 CA5108760	927	S>N		No	ClinGen ExAC gnomAD
rs1262181711 CA373948959	928	L>F		No	ClinGen gnomAD
CA5108759 rs760822939	929	K>N		No	ClinGen ExAC gnomAD
rs775812052 CA373948915	934	C>S		No	ClinGen ExAC TOPMed gnomAD
rs775812052 CA5108758	934	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs1223102393 CA373948899	936	E>G		No	ClinGen gnomAD
CA195544170 rs75851694	937	K>E		No	ClinGen ESP TOPMed
CA195544167 COSM3774389 rs77621374	937	K>N	kidney [Cosmic]	No	ClinGen cosmic curated Ensembl
CA5108756 rs746406782	938	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	939	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA195544136 rs1030833132	940	P>R		No	ClinGen TOPMed gnomAD
CA373948874 rs1326586216	940	P>S		No	ClinGen gnomAD
rs771345012 CA5108753	941	V>M		No	ClinGen ExAC TOPMed gnomAD
CA195544129 rs373223762	942	D>Y		No	ClinGen ESP TOPMed
rs1347757561 CA373948854	943	Q>L		No	ClinGen gnomAD
TCGA novel	946	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751076382	948	Y>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs751076382	948	Y>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA5108750 rs748932794	951	S>G		No	ClinGen ExAC TOPMed gnomAD
CA373948784 rs1394450253	952	K>T		No	ClinGen gnomAD
CA5108748 rs140976292	954	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA373948719 rs1169669115	959	K>Q		No	ClinGen gnomAD
rs1401552190 CA373948640	960	S>C		No	ClinGen TOPMed gnomAD
rs1325181131 CA373948630	961	P>R		No	ClinGen TOPMed
rs1174600730 CA373948625	962	T>A		No	ClinGen gnomAD
CA373948619 rs574993579	962	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5108728 rs574993579	962	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1216437890 CA373948612	963	V>L		No	ClinGen TOPMed
rs780729851 CA5108726	964	V>A		No	ClinGen ExAC gnomAD
CA5108725 rs61742249	966	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373948529 rs1183876167	967	L>F		No	ClinGen TOPMed gnomAD
rs758220164 CA5108722	969	K>R		No	ClinGen ExAC TOPMed gnomAD
rs750274866 CA5108721	970	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5108720 rs778618241	971	E>A		No	ClinGen ExAC gnomAD
rs568993501 CA5108719	971	E>D		No	ClinGen 1000Genomes ExAC gnomAD
COSM1314997 CA373948432 rs1228233994	972	G>C	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	974	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5108718 rs752923002	976	K>E		No	ClinGen ExAC gnomAD
rs1240345863 CA373948371	976	K>R		No	ClinGen gnomAD
CA373948360 rs1587935655	977	D>A		No	ClinGen Ensembl
rs1587935674 CA373948365	977	D>N		No	ClinGen Ensembl
TCGA novel	977	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373948343 rs1339977579	978	C>S		No	ClinGen gnomAD
TCGA novel	979	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5108717 rs767632661	979	P>S		No	ClinGen ExAC gnomAD
TCGA novel	981	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373948251 rs1320129885	985	I>N		No	ClinGen TOPMed gnomAD
rs759537086 CA5108716	985	I>V		No	ClinGen ExAC gnomAD
CA373948207 rs1587935563	988	E>D		No	ClinGen Ensembl
rs752003347 CA5108715	989	P>R		No	ClinGen ExAC gnomAD
rs1399944850 CA373948199	989	P>S		No	ClinGen TOPMed gnomAD
rs1399944850 CA373948203	989	P>T		No	ClinGen TOPMed gnomAD
TCGA novel	990	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	992	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766889476 CA5108714	994	T>A		No	ClinGen ExAC gnomAD
rs1032286989 CA195543788	996	K>R		No	ClinGen TOPMed gnomAD
COSM1463430 CA195543789 rs1032286989	996	K>T	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA5108713 rs763263391	997	F>L		No	ClinGen ExAC
rs1181143633 CA373948083	999	N>T		No	ClinGen gnomAD
CA373948068 rs1426007213	1000	I>T		No	ClinGen TOPMed
rs1478225661 CA373948032	1003	Q>E		No	ClinGen TOPMed
CA5108712 rs773534348	1005	C>Y		No	ClinGen ExAC gnomAD
rs368677840 CA373947970	1007	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1409146270 CA373947746	1011	D>Y		No	ClinGen TOPMed
rs1216866826 CA373947723	1012	F>S		No	ClinGen gnomAD
CA5108692 rs750947417	1014	P>S		No	ClinGen ExAC gnomAD
rs1272322254 CA373947651	1017	I>M		No	ClinGen gnomAD
rs1360297455 CA373947654	1017	I>T		No	ClinGen gnomAD
rs577539994 CA5108691	1017	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs762099737 CA5108690	1019	D>V		No	ClinGen ExAC gnomAD
CA5108689 rs776300053	1020	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA5108688 rs768224224	1024	H>R		No	ClinGen ExAC
rs775121151 CA5108686	1025	I>T		No	ClinGen ExAC gnomAD
rs760444301 CA5108687	1025	I>V		No	ClinGen ExAC gnomAD
CA373947534 rs1344609301	1026	R>W		No	ClinGen gnomAD
CA5108685 rs771769574	1033	I>V		No	ClinGen ExAC TOPMed gnomAD
rs770698141 CA5108682	1036	D>E		No	ClinGen ExAC gnomAD
CA5108683 rs190240395	1036	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373947454 rs1343068976	1037	F>I		No	ClinGen TOPMed
CA373947446 rs1186723247	1038	P>T		No	ClinGen gnomAD
rs1205797370 CA373947423	1039	G>A		No	ClinGen gnomAD
rs372132597 CA5108672	1040	T>A		No	ClinGen ESP ExAC gnomAD
rs1398045027 CA373947379	1046	G>R		No	ClinGen TOPMed
CA5108671 rs140358646	1049	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1178951988 CA373947344	1051	G>E		No	ClinGen gnomAD
rs764605874 CA5108669	1056	Q>K		No	ClinGen ExAC gnomAD
CA5108668 rs374441993	1059	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs372797741 CA5108667	1061	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA373947169 rs1481680445	1064	T>A		No	ClinGen gnomAD
TCGA novel	1065	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767072002 CA5108666	1065	I>V		No	ClinGen ExAC gnomAD
rs192361493 CA5108655	1077	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA5108654 rs757683426	1079	T>S		No	ClinGen ExAC gnomAD
rs1204513985 CA373946639	1084	A>T		No	ClinGen gnomAD
TCGA novel	1086	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1094	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1428082460 CA373946142	1096	I>T		No	ClinGen TOPMed gnomAD
rs201124820 CA195537066	1096	I>V		No	ClinGen 1000Genomes
rs369993282 CA195537060	1098	P>S		No	ClinGen ESP TOPMed
CA5108637 rs771112934	1100	T>A		No	ClinGen ExAC gnomAD
rs749692944 CA5108636	1100	T>I		No	ClinGen ExAC gnomAD
TCGA novel	1111	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373946036 rs1356680304	1112	L>F		No	ClinGen gnomAD
CA5108634 rs756495515	1112	L>S		No	ClinGen ExAC TOPMed gnomAD
CA195537055 rs756495515	1112	L>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1117	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753140997 CA5108633	1120	I>S		No	ClinGen ExAC gnomAD
CA195537040 rs267602298	1122	L>*		No	ClinGen Ensembl
CA373945867 rs1175355934	1135	S>C		No	ClinGen gnomAD
rs377377386 CA195536718	1136	A>S		No	ClinGen ESP
CA5108610 rs781677692	1139	A>T		No	ClinGen ExAC TOPMed gnomAD
CA195536709 rs766442377	1140	I>V		No	ClinGen TOPMed gnomAD
rs1247754608 CA373945827	1142	P>T		No	ClinGen gnomAD
TCGA novel	1148	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755436118 CA5108609	1155	T>A		No	ClinGen ExAC gnomAD
CA373945726 rs1326079400	1156	K>Q		No	ClinGen gnomAD
rs1354766288 CA373945702	1157	M>I		No	ClinGen gnomAD
CA5108589 rs747422258	1157	M>T		No	ClinGen ExAC gnomAD
rs780322849 CA5108588	1160	I>T		No	ClinGen ExAC gnomAD
CA373945649 rs1229683328	1165	R>K		No	ClinGen TOPMed
CA373945612 rs1160363389	1170	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1382775151 CA373945616	1170	S>T		No	ClinGen gnomAD
TCGA novel	1177	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5108583 rs753720708	1188	V>I		No	ClinGen ExAC gnomAD
rs1288840786 CA373945486	1189	I>V		No	ClinGen gnomAD
TCGA novel	1193	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5108563 rs777185017	1196	Y>F		No	ClinGen ExAC gnomAD
CA373945398 rs1279797946	1200	K>E		No	ClinGen gnomAD
rs1454600379 CA373945367	1204	I>V		No	ClinGen TOPMed
rs756052229 CA5108562	1207	D>G		No	ClinGen ExAC gnomAD
CA195536438 rs965069825	1207	D>H		No	ClinGen TOPMed
rs752632467 CA5108561	1208	G>V		No	ClinGen ExAC gnomAD
rs1301200076 CA373945326	1210	N>D		No	ClinGen gnomAD
rs767336256 CA5108560	1211	I>T		No	ClinGen ExAC
rs74799011 CA195536434	1215	D>Y		No	ClinGen Ensembl
CA373945274 rs1388022973	1217	I>V		No	ClinGen TOPMed
CA5108559 rs555488738	1218	D>H		No	ClinGen 1000Genomes ExAC gnomAD
rs749080608 CA5108547	1222	T>I		No	ClinGen ExAC gnomAD
rs1020723279 CA195536127	1223	Y>C		No	ClinGen TOPMed
CA373945193 rs1587884316	1227	C>R		No	ClinGen Ensembl
rs1175619896 CA373945182	1228	G>A		No	ClinGen TOPMed gnomAD
TCGA novel	1230	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1232	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1441603993 CA373945158	1232	E>K		No	ClinGen gnomAD
TCGA novel	1233	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1239065453 CA373945149	1233	S>P		No	ClinGen gnomAD
CA5108545 rs562452720	1234	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA5108541 COSM176657 rs751431949	1243	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5108540 rs41283659	1243	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA373945059 COSM1173523 rs1237388155	1246	T>I	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs199711858 CA5108539	1248	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5108538 rs754076671	1252	K>N		No	ClinGen ExAC gnomAD
TCGA novel	1252	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA195536090 rs960875330	1258	I>V		No	ClinGen TOPMed
rs1304893643 CA373944947	1262	S>R		No	ClinGen gnomAD
CA5108535 rs143293008	1270	Q>E		No	ClinGen ESP ExAC gnomAD
CA5108534 rs768046984	1276	I>F		No	ClinGen ExAC gnomAD
rs768046984 CA373944847	1276	I>V		No	ClinGen ExAC gnomAD
CA373956191 rs1276633499	1285	N>S		No	ClinGen gnomAD
rs866547610 CA195544637	1294	R>G		No	ClinGen Ensembl
rs1398456206 CA373955864	1297	T>A		No	ClinGen gnomAD
CA373955856 rs1333596798	1298	N>D		No	ClinGen gnomAD
CA5108493 rs765682917	1301	M>V		No	ClinGen ExAC gnomAD
CA373955739 rs1447446170	1303	A>S		No	ClinGen TOPMed
CA5108492 rs556996114	1305	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA5108491 rs776429047	1309	R>G		No	ClinGen ExAC
TCGA novel	1315	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5108490 rs763640710	1317	G>R		No	ClinGen ExAC gnomAD
rs760286653 CA5108489	1319	P>S		No	ClinGen ExAC gnomAD
CA373955320 rs1199038765	1326	M>V		No	ClinGen gnomAD
TCGA novel	1326	M>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776791684 CA5108459	1330	F>C		No	ClinGen ExAC gnomAD
rs768834150 CA5108458	1331	D>Y		No	ClinGen ExAC
rs779983516 CA373954918	1340	L>P		No	ClinGen ExAC gnomAD
rs779983516 CA5108456	1340	L>Q		No	ClinGen ExAC gnomAD
rs1296217626 CA373954897	1343	N>K		No	ClinGen TOPMed gnomAD
rs1381727257 CA373954892	1344	D>G		No	ClinGen TOPMed
TCGA novel	1344	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779498023 CA5108453	1353	I>V		No	ClinGen ExAC gnomAD
rs754226413 CA5108451	1354	G>R		No	ClinGen ExAC gnomAD
rs778335133 CA5108450	1356	F>L		No	ClinGen ExAC gnomAD
CA373954804 rs1333921514	1357	M>V		No	ClinGen TOPMed
CA373954761 rs1193594513	1362	M>I		No	ClinGen gnomAD
CA373954766 rs752465514	1362	M>L		No	ClinGen ExAC TOPMed gnomAD
CA5108448 rs752465514	1362	M>V		No	ClinGen ExAC TOPMed gnomAD
CA373954756 rs1468242400	1363	R>K		No	ClinGen gnomAD
CA5108447 rs766868268	1365	K>R		No	ClinGen ExAC gnomAD
rs756546971 CA5108432	1366	V>A		No	ClinGen ExAC gnomAD
CA5108430 rs529420813	1368	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752229778 CA5108431	1368	R>W		No	ClinGen ExAC TOPMed gnomAD
rs570757211 CA5108428	1369	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs754403647 CA5108429	1369	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1277431098 CA373954706	1370	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs200163022 CA5108427	1370	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373954680 rs1219633752	1372	Q>P		No	ClinGen TOPMed
CA195542823 rs1020800934	1373	E>K		No	ClinGen TOPMed
CA5108426 rs150932248	1374	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs150932248 CA373954648	1374	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5108425 rs750427384	1375	A>S		No	ClinGen ExAC gnomAD
CA195542798 rs750056727	1376	L>P		No	ClinGen Ensembl
rs1366311845 CA373954613	1377	N>S		No	ClinGen TOPMed gnomAD
rs1437984771 CA373954603	1378	Q>*		No	ClinGen gnomAD
rs761690761 CA5108423	1378	Q>L		No	ClinGen ExAC gnomAD
CA5108422 rs775536141	1381	P>A		No	ClinGen ExAC gnomAD
CA195542781 rs775536141	1381	P>T		No	ClinGen ExAC gnomAD
rs759728713 CA5108420	1382	E>Q		No	ClinGen ExAC gnomAD
rs1374340732 CA373954526	1383	N>K		No	ClinGen TOPMed gnomAD
rs774563044 CA5108419	1385	E>Q		No	ClinGen ExAC gnomAD
rs771205476 CA5108418	1386	K>E		No	ClinGen ExAC TOPMed gnomAD
CA195542752 rs757682777	1387	R>T		No	ClinGen Ensembl
CA373954456 rs1193046883	1388	S>R		No	ClinGen gnomAD
rs1450686247 CA373954421	1391	D>Y		No	ClinGen TOPMed gnomAD
rs752176398 CA195542747	1392	K>R		No	ClinGen gnomAD
rs956667164 CA195542744	1393	E>G		No	ClinGen Ensembl
CA373954360 rs1587861063	1394	I>T		No	ClinGen Ensembl
CA373954352 rs773864313	1395	H>N		No	ClinGen ExAC gnomAD
CA5108416 rs773864313	1395	H>Y		No	ClinGen ExAC gnomAD
rs866247183 CA195542738	1396	N>D		No	ClinGen Ensembl
rs1000828722 CA195542722	1398	Y>N		No	ClinGen Ensembl
COSM1110760 rs1456291217 CA373954236	1399	T>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1287373208 CA373954190	1401	R>G		No	ClinGen TOPMed
rs76212915 CA195542711	1401	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA
CA5108413 rs76212915	1401	R>T		No	ClinGen ESP ExAC
CA373954152 rs1587860885	1403	V>G		No	ClinGen Ensembl
rs1205145141 CA373954160	1403	V>M		No	ClinGen gnomAD
rs1587860840 CA373954113	1405	T>K		No	ClinGen Ensembl
CA5108410 rs754637918	1409	K>E		No	ClinGen ExAC gnomAD
rs757908948 CA5108407	1411	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1444058284 CA373953977	1412	Q>R		No	ClinGen TOPMed gnomAD
rs564674138 CA5108405	1414	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	1415	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1362500177 CA373953923	1415	P>S		No	ClinGen gnomAD
rs757180847 CA5108404	1417	K>N		No	ClinGen ExAC TOPMed
CA373953800 rs1447742970	1419	K>N		No	ClinGen gnomAD
CA373953797 rs1161753319	1420	P>T		No	ClinGen gnomAD
rs901993371 CA373953766	1421	M>L		No	ClinGen TOPMed gnomAD
CA195542662 rs901993371	1421	M>V		No	ClinGen TOPMed gnomAD
CA195542660 rs201306794	1422	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5108402 rs201306794	1422	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs148400661 CA5108403	1422	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1005518529 CA195542657	1425	A>V		No	ClinGen Ensembl
rs774714607 CA5108400	1427	L>Q		No	ClinGen ExAC gnomAD
CA373953611 rs1177631882	1428	G>E		No	ClinGen gnomAD
TCGA novel	1430	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763152242 CA5108398	1432	I>F		No	ClinGen ExAC TOPMed gnomAD
CA373953524 rs1564028526	1432	I>T		No	ClinGen Ensembl
TCGA novel	1433	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5108395 rs770307301	1434	R>K		No	ClinGen ExAC gnomAD
rs1284602591 CA373953447	1435	P>L		No	ClinGen TOPMed gnomAD
CA373953421 rs1237320823	1436	P>R		No	ClinGen gnomAD
rs541050358 CA5108394	1437	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	1439	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1440	W>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373953349 rs1307234433	1440	W>R		No	ClinGen gnomAD
rs746971309 CA195542645	1442	R>K		No	ClinGen Ensembl
rs1411522134 CA373953218	1445	D>E		No	ClinGen TOPMed
CA5108393 rs61749485	1446	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1459682917 CA373953155	1448	L>*		No	ClinGen gnomAD
rs1377375061 CA373953146 CA373953149	1448	L>F		No	ClinGen TOPMed gnomAD
rs947853078 CA195542626	1449	R>K		No	ClinGen TOPMed gnomAD
rs768970038 CA5108392	1450	E>G		No	ClinGen ExAC gnomAD
CA5108391 rs746598524	1452	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5108390 rs779703706	1452	R>H		No	ClinGen ExAC gnomAD
rs1379202532 CA373952968	1455	I>T		No	ClinGen TOPMed
CA5108388 rs745350559	1456	C>G		No	ClinGen ExAC gnomAD
TCGA novel	1458	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373952835 rs1183541238	1459	E>D		No	ClinGen gnomAD
CA5108386 rs757202943	1459	E>K		No	ClinGen ExAC gnomAD
rs917719398 CA195542594	1465	E>K		No	ClinGen TOPMed gnomAD
CA373952630 rs1213885128	1468	Q>E		No	ClinGen gnomAD
rs1286001048 CA373952531	1472	S>F		No	ClinGen TOPMed
CA5108384 rs777553227	1473	S>L		No	ClinGen ExAC TOPMed gnomAD
rs755936719 CA5108366	1475	S>N		No	ClinGen ExAC TOPMed gnomAD
CA373949980 rs755936719	1475	S>T		No	ClinGen ExAC TOPMed gnomAD
CA195536618 rs1029953046	1478	S>N		No	ClinGen Ensembl
rs752513244 CA5108364	1479	K>T		No	ClinGen ExAC TOPMed gnomAD
rs758681837 CA5108362	1480	Y>C		No	ClinGen ExAC
rs758681837 CA5108363	1480	Y>S		No	ClinGen ExAC
TCGA novel	1481	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143296210 CA5108360	1481	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5108359 rs765295889	1486	A>T		No	ClinGen ExAC gnomAD
rs1463398626 CA373949823	1487	S>T		No	ClinGen gnomAD
rs368748794 CA195536593	1488	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs761811843 CA5108358	1488	A>T		No	ClinGen ExAC TOPMed gnomAD
CA5108357 rs368748794	1488	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1244091055 CA373949777	1490	R>S		No	ClinGen gnomAD
TCGA novel	1491	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373949735 rs1292829979	1493	Q>H		No	ClinGen TOPMed
CA195536583 rs1015072056	1493	Q>K		No	ClinGen Ensembl
rs761217897 CA5108355	1495	S>*		No	ClinGen ExAC gnomAD

No associated diseases with Q5VYS8

8 regional properties for Q5VYS8

Type	Name	Position	InterPro Accession
domain	Zinc finger, CCHC-type	964 - 980	IPR001878-1
domain	Zinc finger, CCHC-type	1346 - 1362	IPR001878-2
domain	Zinc finger, CCHC-type	1452 - 1468	IPR001878-3
domain	PAP/25A-associated	551 - 600	IPR002058-1
domain	PAP/25A-associated	1233 - 1286	IPR002058-2
domain	Matrin/U1-C-like, C2H2-type zinc finger	241 - 275	IPR003604
domain	TUTase nucleotidyltransferase domain	195 - 411	IPR045100-1
domain	TUTase nucleotidyltransferase domain	971 - 1117	IPR045100-2

Functions

		Description
EC Number	2.7.7.52	Nucleotidyltransferases
Subcellular Localization	Cytoplasm	Expression is pancytoplasmic in contrast with TUT4 expression which is enriched in cytoplasmic ribonucleoprotein granules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

6 GO annotations of molecular function

Name	Definition
miRNA binding	Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.
nucleotidyltransferase activity	Catalysis of the transfer of a nucleotidyl group to a reactant.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA uridylyltransferase activity	Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1).
uridylyltransferase activity	Catalysis of the transfer of an uridylyl group to an acceptor.
zinc ion binding	Binding to a zinc ion (Zn).

8 GO annotations of biological process

Name	Definition
miRNA metabolic process	The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
negative regulation of transposition, RNA-mediated	Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate.
nuclear-transcribed mRNA poly(A) tail shortening	Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
oocyte maturation	A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
polyuridylation-dependent mRNA catabolic process	The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA.
pre-miRNA processing	A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.
RNA 3' uridylation	The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule.
RNA 3'-end processing	Any process involved in forming the mature 3' end of an RNA molecule.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5BLK4	Tut7	Terminal uridylyltransferase 7	Mus musculus (Mouse)	PR
A8WHT1	C53A5.17	tRNA (guanine(37)-N1)-methyltransferase	Caenorhabditis elegans	PR
Q5XET5	HESO1	Protein HESO1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0VFA3	tent2	Poly(A) RNA polymerase GLD2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q503I9	tent2	Poly(A) RNA polymerase GLD2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MGDTAKPYFV	KRTKDRGTMD	DDDFRRGHPQ	QDYLIIDDHA	KGHGSKMEKG	LQKKKITPGN
70	80	90	100	110	120
YGNTPRKGPC	AVSSNPYAFK	NPIYSQPAWM	NDSHKDQSKR	WLSDEHTGNS	DNWREFKPGP
130	140	150	160	170	180
RIPVINRQRK	DSFQENEDGY	RWQDTRGCRT	VRRLFHKDLT	SLETTSEMEA	GSPENKKQRS
190	200	210	220	230	240
RPRKPRKTRN	EENEQDGDLE	GPVIDESVLS	TKELLGLQQA	EERLKRDCID	RLKRRPRNYP
250	260	270	280	290	300
TAKYTCRLCD	VLIESIAFAH	KHIKEKRHKK	NIKEKQEEEL	LTTLPPPTPS	QINAVGIAID
310	320	330	340	350	360
KVVQEFGLHN	ENLEQRLEIK	RIMENVFQHK	LPDCSLRLYG	SSCSRLGFKN	SDVNIDIQFP
370	380	390	400	410	420
AIMSQPDVLL	LVQECLKNSD	SFIDVDADFH	ARVPVVVCRE	KQSGLLCKVS	AGNENACLTT
430	440	450	460	470	480
KHLTALGKLE	PKLVPLVIAF	RYWAKLCSID	RPEEGGLPPY	VFALMAIFFL	QQRKEPLLPV
490	500	510	520	530	540
YLGSWIEGFS	LSKLGNFNLQ	DIEKDVVIWE	HTDSAAGDTG	ITKEEAPRET	PIKRGQVSLI
550	560	570	580	590	600
LDVKHQPSVP	VGQLWVELLR	FYALEFNLAD	LVISIRVKEL	VSRELKDWPK	KRIAIEDPYS
610	620	630	640	650	660
VKRNVARTLN	SQPVFEYILH	CLRTTYKYFA	LPHKITKSSL	LKPLNAITCI	SEHSKEVINH
670	680	690	700	710	720
HPDVQTKDDK	LKNSVLAQGP	GATSSAANTC	KVQPLTLKET	AESFGSPPKE	EMGNEHISVH
730	740	750	760	770	780
PENSDCIQAD	VNSDDYKGDK	VYHPETGRKN	EKEKVGRKGK	HLLTVDQKRG	EHVVCGSTRN
790	800	810	820	830	840
NESESTLDLE	GFQNPTAKEC	EGLATLDNKA	DLDGESTEGT	EELEDSLNHF	THSVQGQTSE
850	860	870	880	890	900
MIPSDEEEED	DEEEEEEEEP	RLTINQREDE	DGMANEDELD	NTYTGSGDED	ALSEEDDELG
910	920	930	940	950	960
EAAKYEDVKE	CGKHVERALL	VELNKISLKE	ENVCEEKNSP	VDQSDFFYEF	SKLIFTKGKS
970	980	990	1000	1010	1020
PTVVCSLCKR	EGHLKKDCPE	DFKRIQLEPL	PPLTPKFLNI	LDQVCIQCYK	DFSPTIIEDQ
1030	1040	1050	1060	1070	1080
AREHIRQNLE	SFIRQDFPGT	KLSLFGSSKN	GFGFKQSDLD	VCMTINGLET	AEGLDCVRTI
1090	1100	1110	1120	1130	1140
EELARVLRKH	SGLRNILPIT	TAKVPIVKFF	HLRSGLEVDI	SLYNTLALHN	TRLLSAYSAI
1150	1160	1170	1180	1190	1200
DPRVKYLCYT	MKVFTKMCDI	GDASRGSLSS	YAYTLMVLYF	LQQRNPPVIP	VLQEIYKGEK
1210	1220	1230	1240	1250	1260
KPEIFVDGWN	IYFFDQIDEL	PTYWSECGKN	TESVGQLWLG	LLRFYTEEFD	FKEHVISIRR
1270	1280	1290	1300	1310	1320
KSLLTTFKKQ	WTSKYIVIED	PFDLNHNLGA	GLSRKMTNFI	MKAFINGRRV	FGIPVKGFPK
1330	1340	1350	1360	1370	1380
DYPSKMEYFF	DPDVLTEGEL	APNDRCCRIC	GKIGHFMKDC	PMRRKVRRRR	DQEDALNQRY
1390	1400	1410	1420	1430	1440
PENKEKRSKE	DKEIHNKYTE	REVSTKEDKP	IQCTPQKAKP	MRAAADLGRE	KILRPPVEKW
1450	1460	1470	1480	1490
KRQDDKDLRE	KRCFICGREG	HIKKECPQFK	GSSGSLSSKY	MTQGKASAKR	TQQES