F6HH45

PR
Gene name
VIT_11s0016g04350
Protein name
tRNA (guanine(37)-N1)-methyltransferase 2
Names
M1G-methyltransferase 2, tRNA [GM37] methyltransferase 2, tRNA methyltransferase 5 homolog 2
Species
Vitis vinifera (Grape)
KEGG Pathway
EC number
2.1.1.228: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

275-428 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F6HH45

Entry ID Method Resolution Chain Position Source
AF-F6HH45-F1 Predicted AlphaFoldDB

No variants for F6HH45

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for F6HH45

No associated diseases with F6HH45

5 regional properties for F6HH45

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (D/K/N) 236 - 585 IPR004364
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 108 - 183 IPR004365
domain Aminoacyl-tRNA synthetase, class II 258 - 583 IPR006195
domain Lysyl-tRNA synthetase, class II, C-terminal 251 - 586 IPR018149
domain Lysine-tRNA ligase, class II, N-terminal 106 - 248 IPR044136

Functions

Description
EC Number 2.1.1.228 Methyltransferases
Subcellular Localization
  • Mitochondrion matrix
  • Nucleus
  • Cytoplasm
  • Predominantly in the mitochondria and in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
tRNA (guanine(37)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine.
tRNA (guanine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine.
tRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.

2 GO annotations of biological process

Name Definition
tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.
tRNA N1-guanine methylation The process whereby a guanine in tRNA is methylated at position N1 of the guanine.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38793 TRM5 tRNA (guanine(37)-N1)-methyltransferase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q32P41 TRMT5 tRNA (guanine(37)-N1)-methyltransferase Homo sapiens (Human) PR
A8WHT1 C53A5.17 tRNA (guanine(37)-N1)-methyltransferase Caenorhabditis elegans PR
C5XX79 Sb04g025390 tRNA (guanine(37)-N1)-methyltransferase Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q93YU6 At3g56120 tRNA (guanine(37)-N1)-methyltransferase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MLLDESKFDL QLKLWALRIP SQLCKVASRI LNGYLLDKPR VKPITEDPTC ETNRYIILSE
70 80 90 100 110 120
RIKNPDLSDI PEDKRDELKV LCKIEVVPYS LTLGYSYWSA DHVLKQILPD GVEVPSSFET
130 140 150 160 170 180
ITFSLCHIAH LNITGELLPY KDVIAKVIYD KNYPRIKTVV NKVGTITNEF RVPKFEILVG
190 200 210 220 230 240
KDDMVTEVKQ YRATFKLDYS LVYWNSRLEH EHMRLVSQFR PGQIICDMFS GVGPFAIPAA
250 260 270 280 290 300
QKGCLVYAND LNPDSIRYLK INAKINKVDD NIWAYNMDAR KFISQLMEVP VHEILPEPDV
310 320 330 340 350 360
PVLKATEECS IQANVQTESQ NGGLTVEAIG VHSDDSSNMD GIEGSCTVAD DTVAAVKKHS
370 380 390 400 410 420
GSCEEENGTY DNATVSVVGR RKDRMNKRMR GSESSSNIKP WEHVDHVIMN LPASAIQFLD
430 440 450 460 470 480
AFRGLIQRKY WKGSLPWIHC YCFIRANETN EMIISEAETA LNASIQEPIL HRVRDVAPNK
490 500
AMFCLSFRLS EEACFKEDAT KSLLDSSGDL