P38793
Gene name |
TRM5 |
Protein name |
tRNA (guanine(37)-N1)-methyltransferase |
Names |
M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHR070W |
EC number |
2.1.1.228: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38793
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38793-F1 | Predicted | AlphaFoldDB |
5 variants for P38793
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-234921 | 13 | R>S | No | SGRP | |
| s08-235028 | 49 | C>S | No | SGRP | |
| s08-235099 | 73 | V>M | No | SGRP | |
| s08-235975 | 365 | L>V | No | SGRP | |
| s08-236039 | 386 | E>A | No | SGRP |
No associated diseases with P38793
No regional properties for P38793
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P38793 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.228 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| tRNA (guanine(37)-N(1))-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. |
| tRNA (guanine-N1-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. |
| tRNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial tRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule. |
| tRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. |
| tRNA modification | The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. |
| tRNA N1-guanine methylation | The process whereby a guanine in tRNA is methylated at position N1 of the guanine. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F6HH45 | VIT_11s0016g04350 | tRNA (guanine(37)-N1)-methyltransferase 2 | Vitis vinifera (Grape) | PR |
| Q32P41 | TRMT5 | tRNA (guanine(37)-N1)-methyltransferase | Homo sapiens (Human) | PR |
| A8WHT1 | C53A5.17 | tRNA (guanine(37)-N1)-methyltransferase | Caenorhabditis elegans | PR |
| C5XX79 | Sb04g025390 | tRNA (guanine(37)-N1)-methyltransferase | Sorghum bicolor (Sorghum) (Sorghum vulgare) | PR |
| Q93YU6 | At3g56120 | tRNA (guanine(37)-N1)-methyltransferase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKIALPVFQK | FNRLISSCKM | SGVFPYNPPV | NRQMRELDRS | FFITKIPMCA | VKFPEPKNIS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VFSKNFKNCI | LRVPRIPHVV | KLNSSKPKDE | LTSVQNKKLK | TADGNNTPVT | KGVLLHESIH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SVEDAYGKLP | EDALAFLKEN | SAEIVPHEYV | LDYDFWKAEE | ILRAVLPEQF | LEEVPTGFTI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TGHIAHLNLR | TEFKPFDSLI | GQVILDKNNK | IECVVDKVSS | IATQFRTFPM | KVIAGKSDSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VVEQKESNCT | FKFDFSKVYW | NSRLHTEHER | LVKQYFQPGQ | VVCDVFAGVG | PFAVPAGKKD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VIVLANDLNP | ESYKYLKENI | ALNKVAKTVK | SFNMDGADFI | RQSPQLLQQW | IQDEEGGKIT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IPLPLKKRHR | SQQHNDQQPP | QPRTKELIIP | SHISHYVMNL | PDSAISFLGN | FRGIFAAHTK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GATDTIQMPW | VHVHCFEKYP | PGDQVTEDEL | HARVHARIIA | ALKVTADDLP | LNAVSLHLVR |
| 490 | |||||
| KVAPTKPMYC | ASFQLPANV |