Q93YU6

PR
Gene name
At3g56120 (F18O21_80)
Protein name
tRNA (guanine(37)-N1)-methyltransferase 1
Names
M1G-methyltransferase 1, tRNA [GM37] methyltransferase 1, tRNA methyltransferase 5 homolog 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G56120
EC number
2.1.1.228: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

28-108 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q93YU6

Entry ID Method Resolution Chain Position Source
AF-Q93YU6-F1 Predicted AlphaFoldDB

41 variants for Q93YU6

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH12788856 3 D>N No 1000Genomes
ENSVATH06325078 6 K>T No 1000Genomes
ENSVATH00422225 27 S>A No 1000Genomes
ENSVATH00422225 27 S>T No 1000Genomes
ENSVATH00422226 44 T>S No 1000Genomes
ENSVATH14442294 47 P>S No 1000Genomes
tmp_3_20823710_T_A 65 D>E No 1000Genomes
ENSVATH00422228 73 K>N No 1000Genomes
tmp_3_20824511_A_G 129 H>R No 1000Genomes
ENSVATH02513063 137 D>Y No 1000Genomes
ENSVATH06325090 138 V>L No 1000Genomes
tmp_3_20824741_T_G 170 F>L No 1000Genomes
ENSVATH08158699 179 M>L No 1000Genomes
tmp_3_20824855_G_A 208 M>I No 1000Genomes
tmp_3_20824880_G_A 217 G>R No 1000Genomes
tmp_3_20824892_T_G 221 C>G No 1000Genomes
tmp_3_20824900_G_T 223 M>I No 1000Genomes
ENSVATH00422235 236 Q>L No 1000Genomes
tmp_3_20824967_T_G 246 L>V No 1000Genomes
ENSVATH06325093 253 Y>F No 1000Genomes
tmp_3_20825064_T_G 278 F>C No 1000Genomes
ENSVATH00422236 278 F>L No 1000Genomes
ENSVATH00422237 283 A>V No 1000Genomes
tmp_3_20825127_A_T 299 K>I No 1000Genomes
ENSVATH14442310 306 S>R No 1000Genomes
ENSVATH02513065 310 E>K No 1000Genomes
ENSVATH00422238 323 A>T No 1000Genomes
ENSVATH00422239 325 I>V No 1000Genomes
ENSVATH02513066 341 T>M No 1000Genomes
tmp_3_20825504_G_A 356 A>T No 1000Genomes
ENSVATH00422240 368 A>S No 1000Genomes
ENSVATH14442311 370 P>S No 1000Genomes
tmp_3_20825556_A_G 373 H>R No 1000Genomes
ENSVATH00422249 391 S>L No 1000Genomes
ENSVATH12788913 405 L>R No 1000Genomes
tmp_3_20826139_C_G 427 A>G No 1000Genomes
tmp_3_20826145_C_T 429 T>I No 1000Genomes
ENSVATH14442312 431 L>S No 1000Genomes
tmp_3_20826181_A_G 441 H>R No 1000Genomes
ENSVATH00422253 442 K>R No 1000Genomes
tmp_3_20826353_A_G 468 E>G No 1000Genomes

No associated diseases with Q93YU6

1 regional properties for Q93YU6

Type Name Position InterPro Accession
domain SAM-dependent methyltransferase TRM5/TYW2-type 116 - 461 IPR030382

Functions

Description
EC Number 2.1.1.228 Methyltransferases
Subcellular Localization
  • Mitochondrion matrix
  • Nucleus
  • Cytoplasm
  • Predominantly in the mitochondria and in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
tRNA (guanine(37)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine.
tRNA (guanine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine.
tRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.

2 GO annotations of biological process

Name Definition
tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.
tRNA N1-guanine methylation The process whereby a guanine in tRNA is methylated at position N1 of the guanine.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38793 TRM5 tRNA (guanine(37)-N1)-methyltransferase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
F6HH45 VIT_11s0016g04350 tRNA (guanine(37)-N1)-methyltransferase 2 Vitis vinifera (Grape) PR
Q32P41 TRMT5 tRNA (guanine(37)-N1)-methyltransferase Homo sapiens (Human) PR
A8WHT1 C53A5.17 tRNA (guanine(37)-N1)-methyltransferase Caenorhabditis elegans PR
C5XX79 Sb04g025390 tRNA (guanine(37)-N1)-methyltransferase Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
10 20 30 40 50 60
MFDESKFDVN LKLWALRIPR ELCKSASRIL NGYMLNMPRI KPITEDPTCE KTRLVILSES
70 80 90 100 110 120
VKNADLSEIP EEKLNQLKKL SELEVVPHSV TLGYSYWSAD HLLKQILPDG LDIPSSFETI
130 140 150 160 170 180
GHIAHLNLHD ELLPFKDVIA KVIYDKNYPR IKTIVNKVGT ISNEFRVPKF EVLAGENGME
190 200 210 220 230 240
TEVKQYGARF KLDYGLVYWN SRLEHEHMRL SSLFKPGETV CDMFAGIGPF AIPAAQKGCF
250 260 270 280 290 300
VYANDLNPDS VRYLKINAKF NKVDDLICVH NMDARKFFSH LMAVSTCEDN LQSVADNDKT
310 320 330 340 350 360
KEAAVSRGGE TNSSGEEIRE SNASINEPLG ANKKPSGTTK TENGVGKDCK SIEGHANKRL
370 380 390 400 410 420
RQTLLPIAKP WEHIDHVIMN LPASALQFLD SFSNVIQKKY WKGPLPLIHC YCFIRASETT
430 440 450 460
EFIIAEAETA LKFHIEDPVF HKVRDVAPNK AMFCLSFRLP EACLKQEE