Q9ZPI1
Gene name |
At3g11710 (T19F11.11) |
Protein name |
Lysine--tRNA ligase, cytoplasmic |
Names |
Lysyl-tRNA synthetase, LysRS, Lysyl-tRNA synthetase 1, AtKRS-1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G11710 |
EC number |
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9ZPI1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9ZPI1-F1 | Predicted | AlphaFoldDB |
17 variants for Q9ZPI1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_3705567_G_T | 16 | A>D | No | 1000Genomes | |
| ENSVATH00318133 | 20 | S>Y | No | 1000Genomes | |
| ENSVATH05812296 | 114 | A>T | No | 1000Genomes | |
| ENSVATH05812295 | 120 | P>A | No | 1000Genomes | |
| ENSVATH13900975 | 189 | S>L | No | 1000Genomes | |
| tmp_3_3704363_G_A | 223 | H>Y | No | 1000Genomes | |
| tmp_3_3703756_C_T | 311 | A>T | No | 1000Genomes | |
| ENSVATH05812276 | 345 | V>I | No | 1000Genomes | |
| tmp_3_3703470_T_C | 406 | K>R | No | 1000Genomes | |
| ENSVATH05812271 | 434 | G>E | No | 1000Genomes | |
| tmp_3_3703255_T_C | 444 | I>V | No | 1000Genomes | |
| ENSVATH00318119 | 451 | E>G | No | 1000Genomes | |
| ENSVATH00318120 | 451 | E>K | No | 1000Genomes | |
| ENSVATH00318118 | 472 | Q>L | No | 1000Genomes | |
| tmp_3_3703053_G_C | 481 | L>V | No | 1000Genomes | |
| ENSVATH10618400 | 534 | T>S | No | 1000Genomes | |
| ENSVATH05812264 | 623 | E>Q | No | 1000Genomes |
No associated diseases with Q9ZPI1
5 regional properties for Q9ZPI1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminoacyl-tRNA synthetase, class II (D/K/N) | 258 - 607 | IPR004364 |
| domain | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | 141 - 217 | IPR004365 |
| domain | Aminoacyl-tRNA synthetase, class II | 280 - 609 | IPR006195 |
| domain | Lysyl-tRNA synthetase, class II, C-terminal | 273 - 609 | IPR018149 |
| domain | Lysine-tRNA ligase, class II, N-terminal | 141 - 270 | IPR044136 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.6 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| lysine-tRNA ligase activity | Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). |
| metal ion binding | Binding to a metal ion. |
| tRNA binding | Binding to a transfer RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| lysyl-tRNA aminoacylation | The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32048 | MSK1 | Lysine--tRNA ligase, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P15180 | KRS1 | Lysine--tRNA ligase, cytoplasmic | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P0A8N5 | lysU | Lysine--tRNA ligase, heat inducible | Escherichia coli (strain K12) | PR |
| P0A8N3 | lysS | Lysine--tRNA ligase | Escherichia coli (strain K12) | PR |
| Q6F2U9 | Os03g0586800 | Lysine--tRNA ligase | Oryza sativa subsp japonica (Rice) | PR |
| Q22099 | kars-1 | Lysine--tRNA ligase | Caenorhabditis elegans | PR |
| Q43776 | LYSRS | Lysine--tRNA ligase | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGAADQTTK | ALSELAMDSS | TTLNAAESSA | GDGAGPRSKN | ALKKEQKMKQ | KEEEKRRKDE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKAEKAKQAP | KASSQKAVAA | DDEEMDATQY | YENRLKYLAA | EKAKGENPYP | HKFAVSMSIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KYIETYGSLN | NGDHVENAEE | SLAGRIMSKR | SSSSKLFFYD | LHGDDFKVQV | MADASKSGLD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAEFLKLHSN | AKRGDIVGVI | GFPGKTKRGE | LSIFPRSFIL | LSHCLHMMPR | KADNVNAKKP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EIWVPGQTRN | PEAYVLKDQE | SRYRQRHLDM | ILNVEVRQIF | RTRAKIISYV | RRFLDNKNFL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EVETPMMNMI | AGGAAARPFV | THHNDLDMRL | YMRIAPELYL | KQLIVGGLER | VYEIGKQFRN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EGIDLTHNPE | FTTCEFYMAF | ADYNDLMEMT | EVMLSGMVKE | LTGGYKIKYN | ANGYDKDPIE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IDFTPPFRRI | EMIGELEKVA | KLNIPKDLAS | EEANKYLIDA | CARFDVKCPP | PQTTARLLDK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LVGEFLEPTC | VNPTFIINQP | EIMSPLAKWH | RSKSGLTERF | ELFINKHELC | NAYTELNDPV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VQRQRFADQL | KDRQSGDDEA | MALDETFCNA | LEYGLAPTGG | WGLGIDRLSM | LLTDSLNIKE |
| 610 | 620 | ||||
| VLFFPAMRPP | QEESAAAQAP | LTEEKK |