Q43776

PR
Gene name
LYSRS
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
KEGG Pathway
sly:778357
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q43776

Entry ID Method Resolution Chain Position Source
AF-Q43776-F1 Predicted AlphaFoldDB

No variants for Q43776

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q43776

No associated diseases with Q43776

5 regional properties for Q43776

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (D/K/N) 236 - 585 IPR004364
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 108 - 183 IPR004365
domain Aminoacyl-tRNA synthetase, class II 258 - 583 IPR006195
domain Lysyl-tRNA synthetase, class II, C-terminal 251 - 586 IPR018149
domain Lysine-tRNA ligase, class II, N-terminal 106 - 248 IPR044136

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32048 MSK1 Lysine--tRNA ligase, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P15180 KRS1 Lysine--tRNA ligase, cytoplasmic Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P0A8N5 lysU Lysine--tRNA ligase, heat inducible Escherichia coli (strain K12) PR
P0A8N3 lysS Lysine--tRNA ligase Escherichia coli (strain K12) PR
Q6F2U9 Os03g0586800 Lysine--tRNA ligase Oryza sativa subsp japonica (Rice) PR
Q22099 kars-1 Lysine--tRNA ligase Caenorhabditis elegans PR
Q9ZPI1 At3g11710 Lysine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDSSVSTEPL SKNALKREKK AKEKEQLEQE KKAAAVAKRQ MEQHNLPEND DLDPTQYLAN
70 80 90 100 110 120
RLRNIESLRE SGINPYPHKF FITMSIPEFI SRYAHLNTGE FPEDIDMSLA GRVISKRASS
130 140 150 160 170 180
SKLYFYELLG GGARVQVLAS ARDSDVDAVQ FSNYQSGVKR GDIIGVRGYP GKSKRGELSI
190 200 210 220 230 240
FAKPFIVLAP CLHMLPRRLT SSIVDETRTQ NFQGITAYDT WTPGDLRNPE SYVLRDQETR
250 260 270 280 290 300
YRQRYLDLMM NPEVRALFRT RARIISYIRS FLDNLEFLEV ETPSMNLTAG GASARPFITH
310 320 330 340 350 360
HNELDTELLI RVSPELYLKK LVVGGFDRVY ELGKHFRNEG MDLTHSPEFT MCELYMAYAD
370 380 390 400 410 420
YNDLMDLTEQ LLSGMVKDLT GSYKIRYHAN GLDNEPIEID FTPPFRKIDM LSELEKVANI
430 440 450 460 470 480
SIPRDLSSES ANKHLVDVCE KFDVKCPPPH TTTRLLDKLV GHFIEVNCIN PTFIINHPEI
490 500 510 520 530 540
MSPLAKSRRS EPGLTERFNL FVNRRELCDA YTELNDPTAQ RERFAEQLKD RQLGDDEAMD
550 560 570 580
LDESFITALE YGLPPTGGLG MGIDRLTMLL TDSQNVKEVI LFPAMRLQ