Q6F2U9

PR
Gene name
Os03g0586800 (LOC_Os03g38980, OSJNBa0010D22.26)
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4333345
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6F2U9

Entry ID Method Resolution Chain Position Source
AF-Q6F2U9-F1 Predicted AlphaFoldDB

No variants for Q6F2U9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6F2U9

No associated diseases with Q6F2U9

1 regional properties for Q6F2U9

Type Name Position InterPro Accession
conserved_site Di-trans-poly-cis-decaprenylcistransferase-like, conserved site 245 - 262 IPR018520

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32048 MSK1 Lysine--tRNA ligase, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P15180 KRS1 Lysine--tRNA ligase, cytoplasmic Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P0A8N5 lysU Lysine--tRNA ligase, heat inducible Escherichia coli (strain K12) PR
P0A8N3 lysS Lysine--tRNA ligase Escherichia coli (strain K12) PR
Q22099 kars-1 Lysine--tRNA ligase Caenorhabditis elegans PR
Q9ZPI1 At3g11710 Lysine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
Q43776 LYSRS Lysine--tRNA ligase Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MAESGSSGLE EKLAGLSAGC GEEPQQLSKN AKKREEKRKK QEEERRLKEE EKKKKAAATA
70 80 90 100 110 120
AASGEPPKES AADDEEMDPT QYYENRLKAL DSLKATGVNP YPHKFLANIT VADYIEKYKS
130 140 150 160 170 180
MNVGDKLVDV TECLAGRIMT KRAQSSKLLF YDLYGGGEKV QVFADARTSE LEDNEFIKFH
190 200 210 220 230 240
STLKRGDIVG VCGYPGKSKR GELSIFPKKI VVLSPCLHMM PRQKSEGSAV PTPWAPGMGR
250 260 270 280 290 300
NIEKYVLRDQ ETRYRQRYLD LMVNHEVRHI FKTRSKVVSF IRKFLDGLDF LEVETPMMNM
310 320 330 340 350 360
IAGGAAARPF VTHHNELNMR LYMRIAPELY LKELVVGGLD RVYEIGKQFR NEGIDLTHNP
370 380 390 400 410 420
EFTTCEFYMA YADYNDLIEL TETMLSGMVK ELTGGYKIKY HANGVEKPPI EIDFTPPFRK
430 440 450 460 470 480
IDMIEELEAM AKLNIPKDLS SDEANKYLID ACAKYDVKCP PPQTTTRLLD KLVGHFLEET
490 500 510 520 530 540
CVNPTFIINH PEIMSPLAKW HRSRPGLTER FELFVNKHEV CNAYTELNDP VVQRQRFEEQ
550 560 570 580 590 600
LKDRQSGDDE AMALDETFCT ALEYGLPPTG GWGLGIDRLT MLLTDSQNIK EVLLFPAMKP
QD