AiPD: Autoinhibited Protein Database

Gene name	Kcnj16
Protein name	Inward rectifier potassium channel 16
Names	Inward rectifier K(+) channel Kir5.1, Potassium channel, inwardly rectifying subfamily J member 16
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:16517
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

320-417 (Predicted disordered autoinhibitory region) PR

320-417 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9Z307-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389217355	37	L>H	No	EVA
rs3403088485	68	T>I	No	EVA
rs27005908	75	V>I	No	EVA
rs3389176212	77	F>I	No	EVA
rs3389217326	90	S>C	No	EVA
rs3389222417	116	H>L	No	EVA
rs3389211359	147	V>I	No	EVA
rs3389183856	160	I>L	No	EVA
rs3402889322	174	T>A	No	EVA
rs3402388730	174	T>I	No	EVA
rs3389225595	186	Y>N	No	EVA
rs3389225590	194	D>Y	No	EVA
rs3389148443	197	L>P	No	EVA
rs3389225654	212	V>I	No	EVA
rs3389208165	217	R>K	No	EVA
rs3389176179	226	D>Y	No	EVA
rs3389217510	231	M>T	No	EVA
rs3389214851	246	I>N	No	EVA
rs3389208164	251	V>A	No	EVA
rs3389201258	258	D>Y	No	EVA
rs3389229161	261	S>N	No	EVA
rs3389213785	280	V>E	No	EVA
rs3389211342	288	S>C	No	EVA
rs3389213726	289	T>I	No	EVA
rs3389188588	292	S>T	No	EVA
rs3389188589	294	Q>H	No	EVA
rs3389213747	307	G>S	No	EVA
rs3389189409	311	H>D	No	EVA
rs3402792836	326	L>*	No	EVA
rs3402678565	326	L>M	No	EVA
rs3389211354	338	F>L	No	EVA
rs3389213698	346	W>R	No	EVA
rs27005904	380	V>M	No	EVA
rs3389211276	390	T>S	No	EVA
rs239025052	391	V>I	No	EVA
rs3389229193	412	R>M	No	EVA
rs3402544652	419	M>L	No	EVA

Type	Name	Position	InterPro Accession
domain	Potassium channel, inwardly rectifying, transmembrane domain	38 - 174	IPR040445
domain	Inward rectifier potassium channel, C-terminal	182 - 348	IPR041647

		Description
EC Number
Subcellular Localization	Membrane ; Multi-pass membrane protein Basolateral cell membrane	In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
inward rectifier potassium channel activity	Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.

Name	Definition
potassium ion import across plasma membrane	The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
potassium ion transport	The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of ion transmembrane transport	Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
regulation of pH	Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
response to carbon dioxide	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q4TZY1	KCNJ12	ATP-sensitive inward rectifier potassium channel 12	Bos taurus (Bovine)	PR
F1NHE9	KCNJ12	ATP-sensitive inward rectifier potassium channel 12	Gallus gallus (Chicken)	PR
Q15842	KCNJ8	ATP-sensitive inward rectifier potassium channel 8	Homo sapiens (Human)	PR
P48549	KCNJ3	G protein-activated inward rectifier potassium channel 1	Homo sapiens (Human)	PR
Q14654	KCNJ11	ATP-sensitive inward rectifier potassium channel 11	Homo sapiens (Human)	PR
B7U540	KCNJ18	Inward rectifier potassium channel 18	Homo sapiens (Human)	PR
Q14500	KCNJ12	ATP-sensitive inward rectifier potassium channel 12	Homo sapiens (Human)	PR
P52187	Kcnj12	ATP-sensitive inward rectifier potassium channel 12	Mus musculus (Mouse)	PR
P97794	Kcnj8	ATP-sensitive inward rectifier potassium channel 8	Mus musculus (Mouse)	PR
Q61743	Kcnj11	ATP-sensitive inward rectifier potassium channel 11	Mus musculus (Mouse)	PR
Q8JZN3	Kcnj14	ATP-sensitive inward rectifier potassium channel 14	Mus musculus (Mouse)	PR
P52189	Kcnj4	Inward rectifier potassium channel 4	Mus musculus (Mouse)	PR
Q63664	Kcnj8	ATP-sensitive inward rectifier potassium channel 8	Rattus norvegicus (Rat)	PR
P70673	Kcnj11	ATP-sensitive inward rectifier potassium channel 11	Rattus norvegicus (Rat)	PR
P52188	Kcnj12	ATP-sensitive inward rectifier potassium channel 12	Rattus norvegicus (Rat)	PR