AiPD: Autoinhibited Protein Database

Gene name	Kcnj12 (Irk2)
Protein name	ATP-sensitive inward rectifier potassium channel 12
Names	Inward rectifier K(+) channel Kir2.2, IRK-2, Potassium channel, inwardly rectifying subfamily J member 12
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:16515
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

360-427 (Predicted disordered autoinhibitory region) PR

360-427 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P52187-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389171289	40	R>C	No	EVA
rs3389171289	40	R>G	No	EVA
rs3389102640	41	R>L	No	EVA
rs3389177117	54	N>T	No	EVA
rs3389161339	69	A>T	No	EVA
rs3389173489	75	C>R	No	EVA
rs1132102269	79	R>H	No	EVA
rs3389157728	104	V>I	No	EVA
rs3389102659	111	D>N	No	EVA
rs3401940577	166	S>P	No	EVA
rs3402295586	167	I>T	No	EVA
rs3402581560	168	V>M	No	EVA
rs3402194577	169	G>D	No	EVA
rs3402380473	171	I>T	No	EVA
rs3402194594	171	I>V	No	EVA
rs3389134720	208	K>M	No	EVA
rs3389166091	220	K>N	No	EVA
rs3389151902	220	K>R	No	EVA
rs3389161299	263	F>L	No	EVA
rs3389162802	269	T>I	No	EVA
rs3389166061	280	L>M	No	EVA
rs3389138760	287	D>N	No	EVA
rs3402380498	295	I>S	No	EVA
rs3389134688	316	Y>*	No	EVA
rs3389164961	318	A>S	No	EVA
rs3389151908	331	L>F	No	EVA
rs3389138725	356	R>H	No	EVA
rs3389161515	376	C>S	No	EVA
rs3389173438	399	R>S	No	EVA

Type	Name	Position	InterPro Accession
domain	BTB/POZ domain	25 - 130	IPR000210
domain	Potassium channel tetramerisation-type BTB domain	27 - 118	IPR003131

		Description
EC Number
Subcellular Localization	Membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intrinsic component of membrane	The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
T-tubule	Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.

Name	Definition
inward rectifier potassium channel activity	Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
PDZ domain binding	Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.

Name	Definition
potassium ion import across plasma membrane	The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
potassium ion transport	The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein homotetramerization	The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
regulation of ion transmembrane transport	Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q4TZY1	KCNJ12	ATP-sensitive inward rectifier potassium channel 12	Bos taurus (Bovine)	PR
F1NHE9	KCNJ12	ATP-sensitive inward rectifier potassium channel 12	Gallus gallus (Chicken)	PR
Q15842	KCNJ8	ATP-sensitive inward rectifier potassium channel 8	Homo sapiens (Human)	PR
P48549	KCNJ3	G protein-activated inward rectifier potassium channel 1	Homo sapiens (Human)	PR
Q14654	KCNJ11	ATP-sensitive inward rectifier potassium channel 11	Homo sapiens (Human)	PR
B7U540	KCNJ18	Inward rectifier potassium channel 18	Homo sapiens (Human)	PR
Q14500	KCNJ12	ATP-sensitive inward rectifier potassium channel 12	Homo sapiens (Human)	PR
P97794	Kcnj8	ATP-sensitive inward rectifier potassium channel 8	Mus musculus (Mouse)	PR
Q61743	Kcnj11	ATP-sensitive inward rectifier potassium channel 11	Mus musculus (Mouse)	PR
Q8JZN3	Kcnj14	ATP-sensitive inward rectifier potassium channel 14	Mus musculus (Mouse)	PR
Q9Z307	Kcnj16	Inward rectifier potassium channel 16	Mus musculus (Mouse)	PR
P52189	Kcnj4	Inward rectifier potassium channel 4	Mus musculus (Mouse)	PR
Q63664	Kcnj8	ATP-sensitive inward rectifier potassium channel 8	Rattus norvegicus (Rat)	PR
P70673	Kcnj11	ATP-sensitive inward rectifier potassium channel 11	Rattus norvegicus (Rat)	PR
P52188	Kcnj12	ATP-sensitive inward rectifier potassium channel 12	Rattus norvegicus (Rat)	PR