Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4TZY1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4TZY1-F1 | Predicted | AlphaFoldDB |
91 variants for Q4TZY1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs518095662 | 5 | G>V | No | EVA | |
| rs432087686 | 7 | T>P | No | EVA | |
| rs474699061 | 9 | P>S | No | EVA | |
| rs453725265 | 14 | S>A | No | EVA | |
| rs209941509 | 18 | D>G | No | EVA | |
| rs133696996 | 18 | D>N | No | EVA | |
| rs136456483 | 19 | G>E | No | EVA | |
| rs135292966 | 21 | H>R | No | EVA | |
| rs436580247 | 24 | T>S | No | EVA | |
| rs135326636 | 28 | A>G | No | EVA | |
| rs455079079 | 29 | N>D | No | EVA | |
| rs476907833 | 29 | N>K | No | EVA | |
| rs443909980 | 30 | G>D | No | EVA | |
| rs133744598 | 32 | G>A | No | EVA | |
| rs137427991 | 34 | G>A | No | EVA | |
| rs452500843 | 36 | V>G | No | EVA | |
| rs132723522 | 40 | R>G | No | EVA | |
| rs470950322 | 41 | R>K | No | EVA | |
| rs441342818 | 42 | C>S | No | EVA | |
| rs459787287 | 120 | R>L | No | EVA | |
| rs460949848 | 133 | A>P | No | EVA | |
| rs482748807 | 138 | I>L | No | EVA | |
| rs449873828 | 139 | E>* | No | EVA | |
| rs464999555 | 145 | G>C | No | EVA | |
| rs477032235 | 155 | C>G | No | EVA | |
| rs447383124 | 159 | V>G | No | EVA | |
| rs134412902 | 163 | V>G | No | EVA | |
| rs465825904 | 169 | G>D | No | EVA | |
| rs208892216 | 171 | I>V | No | EVA | |
| rs470348462 | 179 | A>G | No | EVA | |
| rs478601346 | 179 | A>T | No | EVA | |
| rs452714859 | 182 | A>D | No | EVA | |
| rs437519428 | 182 | A>S | No | EVA | |
| rs471055732 | 183 | K>* | No | EVA | |
| rs434781830 | 183 | K>M | No | EVA | |
| rs471055732 | 183 | K>Q | No | EVA | |
| rs453240777 | 187 | P>H | No | EVA | |
| rs442043063 | 188 | K>N | No | EVA | |
| rs461011186 | 191 | A>V | No | EVA | |
| rs443525585 | 197 | S>G | No | EVA | |
| rs458777004 | 199 | N>D | No | EVA | |
| rs477291045 | 201 | V>G | No | EVA | |
| rs135240819 | 202 | V>G | No | EVA | |
| rs459313253 | 203 | A>G | No | EVA | |
| rs481134923 | 209 | L>H | No | EVA | |
| rs448161790 | 212 | M>I | No | EVA | |
| rs437392143 | 232 | L>P | No | EVA | |
| rs464834682 | 248 | Q>H | No | EVA | |
| rs453261954 | 252 | D>G | No | EVA | |
| rs480738163 | 257 | K>N | No | EVA | |
| rs474789521 | 258 | G>D | No | EVA | |
| rs435689537 | 260 | D>A | No | EVA | |
| rs457261635 | 265 | V>G | No | EVA | |
| rs433142585 | 269 | T>I | No | EVA | |
| rs476259678 | 269 | T>P | No | EVA | |
| rs443398511 | 270 | I>T | No | EVA | |
| rs458705346 | 273 | E>A | No | EVA | |
| rs464438987 | 277 | A>D | No | EVA | |
| rs456320992 | 281 | F>Y | No | EVA | |
| rs474760192 | 283 | I>M | No | EVA | |
| rs801281711 | 285 | R>Q | No | EVA | |
| rs453715777 | 286 | Q>E | No | EVA | |
| rs472343975 | 287 | D>E | No | EVA | |
| rs110564520 | 319 | N>S | No | EVA | |
| rs441064731 | 338 | Y>S | No | EVA | |
| rs459367837 | 346 | H>Y | No | EVA | |
| rs480997866 | 354 | T>S | No | EVA | |
| rs210771608 | 356 | R>H | No | EVA | |
| rs481875432 | 372 | T>P | No | EVA | |
| rs716409571 | 373 | N>D | No | EVA | |
| rs446220817 | 374 | S>A | No | EVA | |
| rs464739883 | 379 | N>T | No | EVA | |
| rs480202884 | 384 | L>R | No | EVA | |
| rs447124178 | 387 | D>H | No | EVA | |
| rs468450922 | 390 | D>G | No | EVA | |
| rs435550547 | 392 | V>A | No | EVA | |
| rs457124015 | 398 | S>R | No | EVA | |
| rs433233157 | 404 | R>K | No | EVA | |
| rs525791585 | 405 | R>C | No | EVA | |
| rs452234275 | 406 | D>G | No | EVA | |
| rs470784188 | 407 | F>L | No | EVA | |
| rs441125535 | 408 | D>Y | No | EVA | |
| rs474854390 | 409 | R>K | No | EVA | |
| rs441650429 | 410 | P>A | No | EVA | |
| rs463316611 | 410 | P>R | No | EVA | |
| rs481999655 | 411 | Q>K | No | EVA | |
| rs439266400 | 412 | A>D | No | EVA | |
| rs458313122 | 423 | R>P | No | EVA | |
| rs480043125 | 424 | E>G | No | EVA | |
| rs447147834 | 425 | S>A | No | EVA | |
| rs447147834 | 425 | S>P | No | EVA |
No associated diseases with Q4TZY1
3 regional properties for Q4TZY1
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intrinsic component of membrane | The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| inward rectifier potassium channel activity | Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| potassium ion import across plasma membrane | The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. |
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| protein homotetramerization | The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F1NHE9 | KCNJ12 | ATP-sensitive inward rectifier potassium channel 12 | Gallus gallus (Chicken) | PR |
| Q15842 | KCNJ8 | ATP-sensitive inward rectifier potassium channel 8 | Homo sapiens (Human) | PR |
| P48549 | KCNJ3 | G protein-activated inward rectifier potassium channel 1 | Homo sapiens (Human) | PR |
| Q14654 | KCNJ11 | ATP-sensitive inward rectifier potassium channel 11 | Homo sapiens (Human) | PR |
| B7U540 | KCNJ18 | Inward rectifier potassium channel 18 | Homo sapiens (Human) | PR |
| Q14500 | KCNJ12 | ATP-sensitive inward rectifier potassium channel 12 | Homo sapiens (Human) | PR |
| P97794 | Kcnj8 | ATP-sensitive inward rectifier potassium channel 8 | Mus musculus (Mouse) | PR |
| Q8JZN3 | Kcnj14 | ATP-sensitive inward rectifier potassium channel 14 | Mus musculus (Mouse) | PR |
| P52189 | Kcnj4 | Inward rectifier potassium channel 4 | Mus musculus (Mouse) | PR |
| Q9Z307 | Kcnj16 | Inward rectifier potassium channel 16 | Mus musculus (Mouse) | PR |
| Q61743 | Kcnj11 | ATP-sensitive inward rectifier potassium channel 11 | Mus musculus (Mouse) | PR |
| P52187 | Kcnj12 | ATP-sensitive inward rectifier potassium channel 12 | Mus musculus (Mouse) | PR |
| Q63664 | Kcnj8 | ATP-sensitive inward rectifier potassium channel 8 | Rattus norvegicus (Rat) | PR |
| P70673 | Kcnj11 | ATP-sensitive inward rectifier potassium channel 11 | Rattus norvegicus (Rat) | PR |
| P52188 | Kcnj12 | ATP-sensitive inward rectifier potassium channel 12 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTASGRTNPY | SIVSSEEDGL | HLVTMSGANG | FGNGKVHTRR | RCRNRFVKKN | GQCNIEFANM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DEKSQRYLAD | MFTTCVDIRW | RYMLLIFSLA | FLASWLLFGV | IFWVIAVAHG | DLEPAEAHGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TPCVLQVHGF | MAAFLFSIET | QTTIGYGLRC | VTEECPVAVF | MVVAQSIVGC | IIDSFMIGAI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MAKMARPKKR | AQTLLFSHNA | VVALRDGKLC | LMWRVGNLRK | SHIVEAHVRA | QLIKPRVTEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GEYIPLDQID | IDVGFDKGLD | RIFLVSPITI | LHEIDEASPL | FGISRQDLET | DDFEIVVILE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GMVEATAMTT | QARSSYLANE | ILWGHRFEPV | LFEEKNQYKI | DYSHFHKTYE | VPSTPRCSAK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DLVENKFLLP | STNSFCYENE | LAFLSRDEED | EVDGEQDSLG | PQARRDFDRP | QAGTALEQRP |
| YRRESEI |