F1NHE9

PR
Gene name
KCNJ12
Protein name
ATP-sensitive inward rectifier potassium channel 12
Names
Inward rectifier K(+) channel Kir2.2, Potassium channel, inwardly rectifying subfamily J member 12
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:427662
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

352-429 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

12 structures for F1NHE9

Entry ID Method Resolution Chain Position Source
3JYC X-ray 311 A A 38-369 PDB
3SPC X-ray 245 A A 38-369 PDB
3SPG X-ray 261 A A 38-369 PDB
3SPH X-ray 300 A A 38-369 PDB
3SPI X-ray 331 A A 38-369 PDB
3SPJ X-ray 331 A A 38-369 PDB
5KUK X-ray 200 A A 38-369 PDB
5KUM X-ray 280 A A 38-369 PDB
6M84 X-ray 281 A A 38-369 PDB
6M85 X-ray 271 A A 38-369 PDB
6M86 X-ray 360 A A 38-366 PDB
AF-F1NHE9-F1 Predicted AlphaFoldDB

9 variants for F1NHE9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs737488322 6 V>G No Ensembl
rs316688574 59 M>R No Ensembl
rs733444636 143 T>A No Ensembl
rs736299855 163 V>G No Ensembl
rs739659852 170 C>G No Ensembl
rs737830406 314 S>R No Ensembl
rs317311659 343 S>P No Ensembl
rs731806400 361 D>A No Ensembl
rs317536120 409 F>C No Ensembl

No associated diseases with F1NHE9

3 regional properties for F1NHE9

Type Name Position InterPro Accession
domain Potassium channel, inwardly rectifying, Kir, N-terminal 1 - 45 IPR013673
domain Potassium channel, inwardly rectifying, transmembrane domain 46 - 187 IPR040445
domain Inward rectifier potassium channel, C-terminal 194 - 365 IPR041647

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Multi-pass membrane protein
  • Cell membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intrinsic component of membrane The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
inward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.

4 GO annotations of biological process

Name Definition
potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
potassium ion transport The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein homotetramerization The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q4TZY1 KCNJ12 ATP-sensitive inward rectifier potassium channel 12 Bos taurus (Bovine) PR
Q15842 KCNJ8 ATP-sensitive inward rectifier potassium channel 8 Homo sapiens (Human) PR
P48549 KCNJ3 G protein-activated inward rectifier potassium channel 1 Homo sapiens (Human) PR
Q14654 KCNJ11 ATP-sensitive inward rectifier potassium channel 11 Homo sapiens (Human) PR
B7U540 KCNJ18 Inward rectifier potassium channel 18 Homo sapiens (Human) PR
Q14500 KCNJ12 ATP-sensitive inward rectifier potassium channel 12 Homo sapiens (Human) PR
P97794 Kcnj8 ATP-sensitive inward rectifier potassium channel 8 Mus musculus (Mouse) PR
Q8JZN3 Kcnj14 ATP-sensitive inward rectifier potassium channel 14 Mus musculus (Mouse) PR
P52189 Kcnj4 Inward rectifier potassium channel 4 Mus musculus (Mouse) PR
Q9Z307 Kcnj16 Inward rectifier potassium channel 16 Mus musculus (Mouse) PR
Q61743 Kcnj11 ATP-sensitive inward rectifier potassium channel 11 Mus musculus (Mouse) PR
P52187 Kcnj12 ATP-sensitive inward rectifier potassium channel 12 Mus musculus (Mouse) PR
Q63664 Kcnj8 ATP-sensitive inward rectifier potassium channel 8 Rattus norvegicus (Rat) PR
P70673 Kcnj11 ATP-sensitive inward rectifier potassium channel 11 Rattus norvegicus (Rat) PR
P52188 Kcnj12 ATP-sensitive inward rectifier potassium channel 12 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MTAGRVNPYS IVSSEEDGLR LTTMPGINGF GNGKIHTRRK CRNRFVKKNG QCNVEFTNMD
70 80 90 100 110 120
DKPQRYIADM FTTCVDIRWR YMLLLFSLAF LVSWLLFGLI FWLIALIHGD LENPGGDDTF
130 140 150 160 170 180
KPCVLQVNGF VAAFLFSIET QTTIGYGFRC VTEECPLAVF MVVVQSIVGC IIDSFMIGAI
190 200 210 220 230 240
MAKMARPKKR AQTLLFSHNA VVAMRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRITEE
250 260 270 280 290 300
GEYIPLDQID IDVGFDKGLD RIFLVSPITI LHEINEDSPL FGISRQDLET DDFEIVVILE
310 320 330 340 350 360
GMVEATAMTT QARSSYLASE ILWGHRFEPV LFEEKNQYKV DYSHFHKTYE VPSTPRCSAK
370 380 390 400 410 420
DLVENKFLLP STNSFCYENE LAFMSRDEDE EDDDSRGLDD LSPDNRHEFD RLQATIALDQ
RSYRRESEI