Q9Z2C9

PR
Gene name
Mtmr7
Protein name
Myotubularin-related protein 7
Names
Inositol 1,3-bisphosphate phosphatase, Phosphatidylinositol-3-phosphate phosphatase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:54384
EC number
3.1.3.64: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

489-660 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9Z2C9

Entry ID Method Resolution Chain Position Source
AF-Q9Z2C9-F1 Predicted AlphaFoldDB

31 variants for Q9Z2C9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388978584 39 E>G No EVA
rs3388973260 82 L>F No EVA
rs3388972588 85 P>A No EVA
rs3388978149 89 D>Y No EVA
rs3388950910 154 D>N No EVA
rs3388950966 156 R>K No EVA
rs3388966382 161 Y>F No EVA
rs3399086916 166 Y>C No EVA
rs3398995705 175 I>M No EVA
rs3399071806 178 G>A No EVA
rs3398865517 179 S>I No EVA
rs3388980828 186 R>G No EVA
rs3399212925 195 C>S No EVA
rs3388972585 220 E>K No EVA
rs3399086116 248 M>I No EVA
rs3388950981 252 A>V No EVA
rs3388972624 257 Y>C No EVA
rs3388972629 262 N>K No EVA
rs3399071858 271 I>S No EVA
rs3388980788 284 Q>P No EVA
rs3399071849 295 P>H No EVA
rs3399212112 298 S>R No EVA
rs3388978336 464 W>C No EVA
rs217250429 573 H>N No EVA
rs51274325 585 N>K No EVA
rs213888049 586 S>I No EVA
rs3388980956 589 F>S No EVA
rs3399044784 642 P>H No EVA
rs3398995475 644 E>V No EVA
rs3399008401 646 S>T No EVA
rs3398995420 648 K>M No EVA

No associated diseases with Q9Z2C9

6 regional properties for Q9Z2C9

Type Name Position InterPro Accession
domain Tyrosine-specific protein phosphatases domain 307 - 351 IPR000387
domain Protein-tyrosine phosphatase, catalytic 264 - 432 IPR003595
domain Myotubularin-like, phosphatase domain 109 - 504 IPR010569
active_site Protein-tyrosine phosphatase, active site 336 - 346 IPR016130
domain Myotubularin-related protein 7, protein tyrosine phosphatase domain 132 - 433 IPR030572
domain MTMR7, PH-GRAM domain 1 - 103 IPR036003

Functions

Description
EC Number 3.1.3.64 Phosphoric monoester hydrolases
Subcellular Localization
  • Cytoplasm
  • Endomembrane system ; Peripheral membrane protein ; Cytoplasmic side
  • May partially localize to endosomes and/or the Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
inositol bisphosphate phosphatase activity Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate.
phosphatidylinositol-3-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.

2 GO annotations of biological process

Name Definition
inositol phosphate dephosphorylation The process of removing a phosphate group from any mono- or polyphosphorylated inositol.
phosphatidylinositol dephosphorylation The process of removing one or more phosphate groups from a phosphatidylinositol.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5F452 MTMR8 Myotubularin-related protein 8 Gallus gallus (Chicken) PR
Q96QG7 MTMR9 Myotubularin-related protein 9 Homo sapiens (Human) PR
Q9Y217 MTMR6 Myotubularin-related protein 6 Homo sapiens (Human) PR
Q9Y216 MTMR7 Myotubularin-related protein 7 Homo sapiens (Human) PR
Q9Z2C4 Mtmr1 Myotubularin-related protein 1 Mus musculus (Mouse) PR
Q9Z2C5 Mtm1 Myotubularin Mus musculus (Mouse) PR
Q9Z2D1 Mtmr2 Myotubularin-related protein 2 Mus musculus (Mouse) PR
A2BGG1 mtmr12 Myotubularin-related protein 12 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEHIRTPKVE NVRLVDRVSC KKAALGTLYL TATHVIFVEN APDTRKETWI LHSQISTIEK
70 80 90 100 110 120
QATTATGCPL LIRCKNFQIV QLVIPQERDC HDVYISLIRL ARPVKYEELY CFSFNPKLDK
130 140 150 160 170 180
EEREQGWLLV DLSEEYKRMG LPDNYWQLSD VNRDYRVCDS YPTELYVPRS ATAHIIVGSS
190 200 210 220 230 240
KFRSRRRFPA LSYYCKDSHA SICRSSQPLS GFSARCLEDE QMLQAIRKAN PGSDFIYVVD
250 260 270 280 290 300
TRPKLNAMAN RAAGKGYENE DNYSNIKFQF IGIENIHVMR NSLQKMLEVC ELKSPSMSDF
310 320 330 340 350 360
LWGLENSGWL RHIKAIMDAG IFIAKAVSEE GASVLVHCSD GWDRTAQVCS VASLLLDPYY
370 380 390 400 410 420
RTLKGFMVLI EKDWISFGHK FNHRYGNLDG DPKEISPVID QFIECVWQLT EQFPCAFEFN
430 440 450 460 470 480
ERFLTHIQHH VYSCQFGNFL CNSQKERREL KIQERTYSLW SNLWKNRADY LNPLFRADHS
490 500 510 520 530 540
QTQGSLHLPT APCNFTYKFW NGMYNRFEKG LQPRQSVTDY LMAVKEESQQ LEEELESLEE
550 560 570 580 590 600
RLEKIQKVHL HGTKVKSKQS EPSKHSGFST SDHSTANTPQ DYSGNSKSFP SRSPSQGDED
610 620 630 640 650
SALILTQDNL KSSDPDLSVN SDQESGVEDL SCRSPSGGEH APSEDSGKDR DSDEAVFLTA