AiPD: Autoinhibited Protein Database

Q9Y217

Gene name	MTMR6
Protein name	Myotubularin-related protein 6
Names	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9107
EC number	3.1.3.64: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

516-621 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

516-621 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9Y217

Entry ID	Method	Resolution	Chain	Position	Source
2YF0	X-ray	265 A	A	1-505	PDB
AF-Q9Y217-F1	Predicted				AlphaFoldDB

463 variants for Q9Y217

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1334003439 CA387598873	3	H>N		No	ClinGen TOPMed gnomAD
rs1392461566 CA387598869	3	H>R		No	ClinGen gnomAD
rs779343299 CA6921727	4	I>T		No	ClinGen ExAC TOPMed gnomAD
CA247128099 rs996238686	5	R>G		No	ClinGen TOPMed gnomAD
rs755332397 CA6921726	5	R>Q		No	ClinGen ExAC gnomAD
CA247128097 rs996238686	5	R>W		No	ClinGen TOPMed gnomAD
rs370445501 CA6921725	6	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA387598853 rs370445501	6	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs764356839 CA247128091	6	T>S		No	ClinGen Ensembl
CA6921723 rs755660799	8	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs749965290 CA6921722	8	K>R		No	ClinGen ExAC gnomAD
rs746300978	9	V>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1283066457 CA387611739	9	V>F		No	ClinGen gnomAD
rs373972921 CA387611729	10	E>*		No	ClinGen ExAC TOPMed gnomAD
rs373972921 CA6921700	10	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA387611709 rs1456450407	11	Q>R		No	ClinGen gnomAD
rs763812697 CA6921697	12	V>I		No	ClinGen ExAC gnomAD
rs763812697 CA6921698	12	V>L		No	ClinGen ExAC gnomAD
rs1284569072 CA387611674	14	L>S		No	ClinGen TOPMed
CA387611668 rs1566042343	15	L>F		No	ClinGen Ensembl
CA387611665 rs1326298980	15	L>R		No	ClinGen TOPMed
CA387611664 rs1220303952	16	D>N		No	ClinGen TOPMed
CA247112276 rs758304228	17	R>*		No	ClinGen ExAC TOPMed gnomAD
rs956599398 CA247112248	17	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6921695 rs761285926 COSM550969	19	S>G	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1488046144 CA387611634	20	T>S		No	ClinGen TOPMed
rs1198430836 CA387611618	22	N>K		No	ClinGen TOPMed gnomAD
rs201075999 CA6921694	22	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs759554451 CA6921693	24	S>*		No	ClinGen ExAC gnomAD
rs776430914 CA6921692	25	L>V		No	ClinGen ExAC gnomAD
TCGA novel	26	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6921691 rs767695916	26	T>R		No	ClinGen ExAC gnomAD
CA247112203 rs866371460	26	T>S		No	ClinGen Ensembl
rs1282217156 CA387611590	27	G>A		No	ClinGen gnomAD
CA6921690 rs761777003	28	T>I		No	ClinGen ExAC gnomAD
rs774674489 CA6921688	32	T>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	33	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768897502 CA6921687	34	T>K		No	ClinGen ExAC gnomAD
rs999078942 CA247112166	34	T>P		No	ClinGen TOPMed
TCGA novel	35	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200532795 CA247112151	35	H>Y		No	ClinGen Ensembl
CA247112113 rs371374084	39	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1359504442 CA387611517	39	I>T		No	ClinGen TOPMed
CA6921686 rs749462663	39	I>V		No	ClinGen ExAC gnomAD
CA6921683 rs746451096	40	D>E		No	ClinGen ExAC gnomAD
CA6921684 rs376766637	40	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs376766637 CA387611515	40	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA387611505 rs1470634026	41	S>C		No	ClinGen gnomAD
rs1245745552 CA387611509	41	S>P		No	ClinGen TOPMed gnomAD
rs542253884 CA387611504	42	H>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6921682 rs542253884	42	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387611430 rs1356157916	50	H>Y		No	ClinGen gnomAD
CA387611422 rs1170917427	51	H>Y		No	ClinGen TOPMed gnomAD
rs1388562103 CA387611407	53	I>V		No	ClinGen gnomAD
rs1209501000 CA387611390	55	S>L		No	ClinGen TOPMed
rs1023095584 CA387611357	60	A>G		No	ClinGen TOPMed gnomAD
rs1023095584 CA247107715	60	A>V		No	ClinGen TOPMed gnomAD
rs774316319 CA6921670	64	S>Y		No	ClinGen ExAC gnomAD
rs373692629 CA6921669	66	C>G		No	ClinGen ESP ExAC gnomAD
rs1200951697 CA387611316	67	P>R		No	ClinGen TOPMed
rs73168506 CA6921668	69	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1436419448 CA387611285	72	C>G		No	ClinGen gnomAD
CA6921667 rs200041102	72	C>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	72	C>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770198319 CA6921666	77	T>I		No	ClinGen ExAC gnomAD
TCGA novel	80	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6921664 rs746194230	81	I>F		No	ClinGen ExAC TOPMed gnomAD
CA6921663 rs150067703	81	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs746194230 CA387611221	81	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6921662 rs747495505	82	V>F		No	ClinGen ExAC TOPMed gnomAD
CA6921661 rs747495505	82	V>L		No	ClinGen ExAC TOPMed gnomAD
CA387611209 rs1298619616	83	P>L		No	ClinGen TOPMed gnomAD
rs201847247 CA247107612	83	P>T		No	ClinGen Ensembl
CA387611197 rs1434126621	85	E>G		No	ClinGen gnomAD
rs374866327 CA6921660	86	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs771706244 CA6921658	87	D>E		No	ClinGen ExAC TOPMed gnomAD
rs564587516 CA6921655	90	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA6921656 rs144877646	90	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1336139418 CA387611147	92	Y>S		No	ClinGen TOPMed gnomAD
TCGA novel	94	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372326300 CA6921651	97	Q>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs372326300 CA6921652	97	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA387611108 rs1471838382	98	L>P		No	ClinGen gnomAD
rs764224853 CA6921650	100	K>I		No	ClinGen ExAC gnomAD
rs781082038 CA6921632	102	A>E		No	ClinGen ExAC TOPMed gnomAD
CA387611056 rs1327006185	104	Y>C		No	ClinGen gnomAD
CA387611048 rs1452966856	105	E>A		No	ClinGen TOPMed
rs758510620 CA6921631	106	D>G		No	ClinGen ExAC gnomAD
CA387611040 rs758510620	106	D>V		No	ClinGen ExAC gnomAD
TCGA novel	106	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387611035 rs1367231010	107	L>F		No	ClinGen TOPMed
CA387611036 rs1367231010	107	L>V		No	ClinGen TOPMed
TCGA novel	110	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387611007 rs1223956564	111	S>A		No	ClinGen TOPMed gnomAD
rs765308332 CA6921629	115	K>E		No	ClinGen ExAC gnomAD
CA387610971 rs1384113248	116	Q>R		No	ClinGen TOPMed gnomAD
CA6921628 rs201090774	117	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6921626 rs766714211	118	D>G		No	ClinGen ExAC gnomAD
CA6921627 rs758220750	118	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs761102682 CA6921625	119	S>T		No	ClinGen ExAC gnomAD
CA387610939 rs1177768356	121	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1177768356 CA387610940	121	R>G		No	ClinGen TOPMed gnomAD
rs772738962 CA6921624	121	R>L		No	ClinGen ExAC TOPMed gnomAD
rs772738962 CA6921623	121	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA387610918 rs1278455877	125	W>R		No	ClinGen TOPMed gnomAD
rs762361830 CA6921622	128	I>F		No	ClinGen ExAC gnomAD
rs1490955170 CA387610889	129	D>N		No	ClinGen TOPMed
rs34885345 VAR_057143 CA6921619	131	A>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6921617 COSM550970 rs769522305	134	Y>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6921616 rs745628437	135	K>R		No	ClinGen ExAC TOPMed gnomAD
CA387610840 rs1204188317	136	R>G		No	ClinGen gnomAD
rs1254054279 CA387610827	137	M>I		No	ClinGen TOPMed gnomAD
CA6921615 rs780920630	137	M>T		No	ClinGen ExAC gnomAD
TCGA novel	138	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387610816 rs1156826863	139	V>G		No	ClinGen TOPMed
rs746884993 CA6921613 CA6921614	139	V>L		No	ClinGen ExAC gnomAD
CA387610813 rs1308303531	140	P>S		No	ClinGen gnomAD
rs755074192 CA6921611	141	N>D		No	ClinGen ExAC TOPMed gnomAD
rs755074192 CA6921612	141	N>H		No	ClinGen ExAC TOPMed gnomAD
CA387610797 rs1302290106	143	H>N		No	ClinGen TOPMed
CA6921609 rs766594014	143	H>R		No	ClinGen ExAC gnomAD
rs756366833 CA6921608	145	Q>L		No	ClinGen ExAC gnomAD
rs78343284 CA247106191	146	L>V		No	ClinGen TOPMed
CA6921607 rs750840801	147	S>C		No	ClinGen ExAC gnomAD
rs201602182 CA6921606	148	D>V		No	ClinGen ExAC TOPMed gnomAD
CA6921605 rs142949277	150	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA247106173 rs142949277	150	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	150	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs116067614 CA247106133	151	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs116067614 CA6921603	151	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774917676 CA6921604	151	R>W		No	ClinGen ExAC TOPMed gnomAD
rs775042821 CA6921601	152	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs201338283 CA247106115	153	Y>*		No	ClinGen TOPMed
CA247106119 rs992398069	153	Y>H		No	ClinGen TOPMed
CA387610728 rs1206914919	154	K>E		No	ClinGen TOPMed
rs1441803143 CA387610726	154	K>T		No	ClinGen gnomAD
CA387610709 rs1415062972	155	I>F		No	ClinGen gnomAD
rs757680773 CA6921585	155	I>T		No	ClinGen ExAC gnomAD
CA6921583 rs764628576	156	C>G		No	ClinGen ExAC gnomAD
CA6921582 rs763327021	159	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs775083393 CA6921581	161	R>G		No	ClinGen ExAC gnomAD
CA387610659 rs1354333789	162	E>D		No	ClinGen gnomAD
CA387610656 rs1281825017	163	L>V		No	ClinGen gnomAD
rs1418461139 CA387610650	164	Y>H		No	ClinGen TOPMed
rs1240365931 CA387610638	165	V>G		No	ClinGen gnomAD
CA387610634 rs1350356028	166	P>H		No	ClinGen gnomAD
rs759255438 CA6921579	167	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1008845745 CA247105887	167	R>W		No	ClinGen TOPMed gnomAD
rs1407077283 CA387610623	168	I>M		No	ClinGen gnomAD
rs765129815 CA6921577	168	I>V		No	ClinGen TOPMed gnomAD
rs893651931 CA247105865	175	V>G		No	ClinGen TOPMed
CA6921576 rs776255478	177	S>R		No	ClinGen ExAC gnomAD
rs1404313743 CA387610557	178	S>C		No	ClinGen gnomAD
TCGA novel	179	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760490843 CA6921574	181	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6921575 rs770766364	181	R>W		No	ClinGen ExAC TOPMed gnomAD
CA387610524 rs1271151050	183	K>N		No	ClinGen TOPMed
rs567451807 CA6921573	183	K>R		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	185	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6921572 rs772069465	186	F>V		No	ClinGen ExAC TOPMed gnomAD
rs1179751603 CA387610500	187	P>S		No	ClinGen gnomAD
rs553822893 CA6921571	188	V>A		No	ClinGen 1000Genomes ExAC gnomAD
rs999283486 CA247105852	188	V>L		No	ClinGen TOPMed gnomAD
rs780287250 CA6921570	189	L>V		No	ClinGen ExAC TOPMed gnomAD
rs769988246 CA6921569	192	Y>C		No	ClinGen ExAC gnomAD
rs746149245 CA6921568	193	H>R		No	ClinGen ExAC TOPMed gnomAD
CA387610454 rs1329083341	194	Q>P		No	ClinGen TOPMed gnomAD
CA6921567 rs146343671	195	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs142057652 CA6921565	197	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1463523432 CA387610409	199	A>T		No	ClinGen TOPMed
rs745911676 CA6921550	199	A>V		No	ClinGen ExAC TOPMed gnomAD
rs781377017 CA6921549	202	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA387610387 rs1363792767	202	R>Q		No	ClinGen gnomAD
CA387610385 rs1456705003	203	C>R		No	ClinGen TOPMed
TCGA novel	204	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778201758 CA6921546	206	P>S		No	ClinGen ExAC gnomAD
rs1267018881 CA387610346	208	S>C		No	ClinGen TOPMed
CA387610347 rs1267018881	208	S>Y		No	ClinGen TOPMed
rs755442387 CA6921542	219	H>L		No	ClinGen ExAC gnomAD
CA6921541 rs753369899	219	H>Q		No	ClinGen ExAC gnomAD
CA387610253 rs1462175660	222	Q>K		No	ClinGen gnomAD
rs750041243 CA6921538	224	I>V		No	ClinGen ExAC gnomAD
CA387610232 rs1439904367	225	S>G		No	ClinGen gnomAD
CA387610231 rs1439904367	225	S>R		No	ClinGen gnomAD
TCGA novel	227	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6921537 rs767403256	228	N>S		No	ClinGen ExAC TOPMed gnomAD
CA6921536 rs149526134	229	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387610203 rs149526134	229	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1294814759 CA387610193	231	N>H		No	ClinGen gnomAD
CA387610183 rs1247448479	232	R>C		No	ClinGen gnomAD
rs565072549 CA6921534	232	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387610176 rs1283515416	233	Y>C		No	ClinGen gnomAD
CA6921532 rs141278425	236	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA387610155 rs141278425	236	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1429371845 CA387610144	237	M>I		No	ClinGen gnomAD
CA6921530 rs747320057	237	M>T		No	ClinGen ExAC gnomAD
rs138843894 CA6921531	237	M>V		No	ClinGen ESP ExAC TOPMed
rs773288042 CA6921529	238	D>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	245	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs188749833 CA6921502	246	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1303791833 CA387609469	248	N>S		No	ClinGen gnomAD
rs1465801628 CA387609455	250	A>V		No	ClinGen gnomAD
CA247100010 rs949294462	253	K>N		No	ClinGen TOPMed
rs1376772961 CA387609434	254	G>S		No	ClinGen TOPMed gnomAD
CA387609429 rs1173511061	254	G>V		No	ClinGen gnomAD
rs1187342106 CA387609398	258	E>D		No	ClinGen gnomAD
rs1452837606 CA387609390	259	D>E		No	ClinGen TOPMed
CA387609393 rs1447590175	259	D>G		No	ClinGen gnomAD
CA6921500 rs745400437	260	N>D		No	ClinGen ExAC TOPMed gnomAD
CA387609383 COSM3793220 rs1430653449	260	N>K	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs745400437 CA6921499	260	N>Y		No	ClinGen ExAC TOPMed gnomAD
CA247099997 rs916475978	261	Y>C		No	ClinGen TOPMed
rs780703365 CA6921498	264	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1365899712 CA387609350	265	R>S		No	ClinGen TOPMed
CA247099983 rs990707587	268	F>S		No	ClinGen TOPMed gnomAD
rs749423542 CA6921497	269	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	270	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	270	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6921496 rs751186788	271	I>T		No	ClinGen ExAC TOPMed gnomAD
rs758251074 CA6921494	272	E>K		No	ClinGen ExAC gnomAD
TCGA novel	274	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752725814 CA247099945	275	H>P		No	ClinGen ExAC TOPMed gnomAD
CA6921493 rs752725814	275	H>R		No	ClinGen ExAC TOPMed gnomAD
rs759473296 CA6921491	277	M>T		No	ClinGen ExAC TOPMed gnomAD
rs113245616 CA247099904	279	S>P		No	ClinGen Ensembl
CA387609238 rs1344847065	282	Q>*		No	ClinGen TOPMed
TCGA novel	282	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762090917 CA6921489	284	L>I		No	ClinGen ExAC gnomAD
CA6921468 rs191265745	288	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1439448306 CA387609121	289	G>V		No	ClinGen TOPMed
rs764329479 CA6921467	296	N>S		No	ClinGen ExAC gnomAD
CA6921466 rs377589798	299	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1232068281 CA387608920	300	S>P		No	ClinGen TOPMed
CA387608897 rs1593144654	301	G>A		No	ClinGen Ensembl
COSM75480 CA6921464 rs770125533	301	G>S	ovary Variant assessed as Somatic; 0.0 impact. stomach [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6921463 rs760023881	303	E>K		No	ClinGen ExAC gnomAD
CA387608856 rs1443506247	304	S>G		No	ClinGen TOPMed
rs777179785 CA6921462	305	S>L		No	ClinGen ExAC TOPMed gnomAD
rs777372172 CA6921459	306	G>V		No	ClinGen ExAC TOPMed gnomAD
CA387608808 rs1328876968	309	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6921458 rs371573306	309	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs747774717 CA6921457	310	H>R		No	ClinGen ExAC gnomAD
CA387608750 rs1593144607	312	K>E		No	ClinGen Ensembl
CA247099373 rs966964390	313	A>P		No	ClinGen Ensembl
rs754789122 CA6921455	314	V>A		No	ClinGen ExAC TOPMed gnomAD
rs199560173 CA6921456	314	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA6921452 rs756002800	315	M>T		No	ClinGen ExAC
CA6921453 rs779937002	315	M>V		No	ClinGen ExAC TOPMed gnomAD
CA387608670 rs1457607425	316	D>G		No	ClinGen gnomAD
CA6921451 rs751659945	318	A>T		No	ClinGen ExAC gnomAD
CA387608613 rs1593144564	319	I>S		No	ClinGen Ensembl
CA6921450 rs7995033 VAR_024583	319	I>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs765574877 CA6921447	323	K>R		No	ClinGen ExAC gnomAD
CA387608442 rs758487623	325	I>L		No	ClinGen ExAC TOPMed gnomAD
rs752908419 CA6921428	325	I>M		No	ClinGen ExAC gnomAD
rs758487623 CA6921429	325	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1449402742 CA387608433	326	T>I		No	ClinGen gnomAD
CA6921427 rs765465503	328	E>A		No	ClinGen ExAC gnomAD
TCGA novel	330	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755109750 CA6921426	331	S>G		No	ClinGen ExAC
rs754271350 CA6921425	331	S>N		No	ClinGen ExAC gnomAD
CA387608401 rs1443344746	331	S>R		No	ClinGen gnomAD
CA387608397 rs1199504348	332	V>G		No	ClinGen gnomAD
rs766786838 CA6921424	332	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1299726189 CA387608392	333	L>*		No	ClinGen TOPMed
rs773843434 CA387608377	335	H>L		No	ClinGen ExAC TOPMed gnomAD
CA6921422 rs773843434	335	H>P		No	ClinGen ExAC TOPMed gnomAD
rs773843434 CA387608378	335	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1228406646 CA387608369	336	C>F		No	ClinGen gnomAD
rs1384493319 CA387608360	338	D>N		No	ClinGen TOPMed
rs1340825416 CA387608337	341	D>Y		No	ClinGen gnomAD
CA387608319 rs1396906465	343	T>N		No	ClinGen gnomAD
rs1396906465 CA387608318	343	T>S		No	ClinGen gnomAD
CA387608312 rs1311363852	344	S>C		No	ClinGen TOPMed
TCGA novel CA6921418 rs768375071	345	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
rs201046935 CA6921419	345	Q>P		No	ClinGen 1000Genomes ExAC gnomAD
rs367847671 CA6921416	349	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6921415 rs769573063	355	D>N		No	ClinGen ExAC gnomAD
CA387608234 rs1253531377	357	Y>H		No	ClinGen TOPMed
rs745859352 CA6921414	358	Y>C		No	ClinGen ExAC gnomAD
CA247098935 rs145423282	359	R>G		No	ClinGen ESP TOPMed
rs781082057 CA6921413	359	R>K		No	ClinGen ExAC gnomAD
CA387608214 rs1301554414	360	T>A		No	ClinGen gnomAD
CA387608200 rs1185815005	362	K>E		No	ClinGen gnomAD
rs778804235 CA6921410	362	K>I		No	ClinGen ExAC gnomAD
CA6921411 rs778804235	362	K>T		No	ClinGen ExAC gnomAD
rs75005059 CA6921409	365	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1163239794 CA387607656	367	L>S		No	ClinGen gnomAD
rs763445618 CA6921400	368	I>M		No	ClinGen ExAC gnomAD
TCGA novel	370	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA247097141 rs724159943 COSM142824	372	W>C	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1253580631 CA387607614	373	I>L		No	ClinGen gnomAD
CA387607608 rs1182425109	373	I>M		No	ClinGen gnomAD
rs762660393 CA6921399	374	S>A		No	ClinGen ExAC gnomAD
CA247097130 rs1031846467	375	F>S		No	ClinGen Ensembl
rs775107085 CA6921398	378	K>E		No	ClinGen ExAC gnomAD
TCGA novel	380	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6921375 rs759133059	384	G>A		No	ClinGen ExAC TOPMed gnomAD
rs546355191 CA247096830	387	D>V		No	ClinGen 1000Genomes
rs1303659495 CA387607491	389	D>Y		No	ClinGen gnomAD
CA6921374 rs577631883	391	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs770628146 CA6921373	392	E>K		No	ClinGen ExAC gnomAD
CA6921371 rs773005544	393	V>G		No	ClinGen ExAC gnomAD
CA6921372 rs760724524	393	V>I		No	ClinGen ExAC
CA387607448 rs1483124155	396	V>L		No	ClinGen gnomAD
rs1593142187 CA387607414	400	F>L		No	ClinGen Ensembl
TCGA novel	402	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387607404 rs1253325956	402	E>Q		No	ClinGen gnomAD
rs887050329 CA247096798	403	C>G		No	ClinGen Ensembl
CA6921370 rs150032485	405	W>*		No	ClinGen ESP ExAC gnomAD
TCGA novel	406	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387607313 rs749413375	407	L>F		No	ClinGen ExAC TOPMed gnomAD
rs775665301 CA6921368	408	T>S		No	ClinGen ExAC gnomAD
rs139661960 CA6921367	409	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA387607258 rs1198305928	410	Q>R		No	ClinGen TOPMed
rs1040112845 CA247096753	411	F>L		No	ClinGen TOPMed
rs1246015107 CA387607223	412	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs781666060 CA6921365	413	Q>R		No	ClinGen ExAC gnomAD
rs79053319 CA6921364	414	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA247096722 rs79053319	414	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387607141 rs1248506193	417	F>I		No	ClinGen gnomAD
CA6921363 rs747599856	418	S>R		No	ClinGen ExAC gnomAD
rs1484753778 CA387607086	420	A>P		No	ClinGen gnomAD
CA387607077 rs1258038397	420	A>V		No	ClinGen gnomAD
rs778111295 CA6921362 COSM432246	423	L>F	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA387607054 rs1566034932	423	L>R		No	ClinGen Ensembl
rs868801491 CA247096719	424	Q>H		No	ClinGen Ensembl
CA387607030 rs1195654020	426	H>L		No	ClinGen TOPMed
rs568415307 CA247096711	427	E>K		No	ClinGen 1000Genomes
CA247096685 rs1049973322	429	I>T		No	ClinGen TOPMed
rs1311260899 CA387606922	432	C>F		No	ClinGen gnomAD
CA387606930 rs1230631567	432	C>S		No	ClinGen gnomAD
rs1044879824 COSM1300099 CA247096679	433	Q>R	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
TCGA novel	434	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387606877 rs1453813241	434	F>S		No	ClinGen TOPMed
rs1366639942 CA387606847	436	N>D		No	ClinGen gnomAD
rs764662535 CA6921359	438	L>P		No	ClinGen ExAC gnomAD
rs754693450 CA6921358	441	C>Y		No	ClinGen ExAC gnomAD
CA6921357 rs755003740	443	K>E		No	ClinGen ExAC TOPMed gnomAD
CA387606657 rs1466258370	446	E>G		No	ClinGen gnomAD
CA247096659 rs866722196	449	K>R		No	ClinGen TOPMed gnomAD
rs774413920 CA6921329	451	K>E		No	ClinGen ExAC gnomAD
CA247095554 rs770216169	452	E>A		No	ClinGen Ensembl
rs1333109750 CA387606345	454	T>A		No	ClinGen gnomAD
CA6921326 rs776731789	460	F>V		No	ClinGen ExAC gnomAD
CA247095503 rs138289796 COSM110035	461	L>F	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA247095498 rs76317728	462	L>F		No	ClinGen ESP TOPMed
rs771079522 CA6921323	463	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1210536179 CA387606281	464	D>N		No	ClinGen TOPMed
rs1000771043 CA387606273	465	Q>E		No	ClinGen TOPMed
CA247095495 rs1000771043	465	Q>K		No	ClinGen TOPMed
rs760892112 CA6921322	468	Y>H		No	ClinGen ExAC gnomAD
rs1392882373 CA387606233	470	N>Y		No	ClinGen gnomAD
rs772413591 CA6921320	472	L>F		No	ClinGen ExAC gnomAD
rs772413591 CA6921321	472	L>V		No	ClinGen ExAC gnomAD
rs748703971 CA6921319	474	S>C		No	ClinGen ExAC TOPMed gnomAD
CA6921315 rs779561417	476	E>D		No	ClinGen ExAC gnomAD
rs370493335 CA6921316	476	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6921314 rs755729166	477	S>T		No	ClinGen ExAC TOPMed gnomAD
rs201709535 CA6921312	479	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs898703950 CA247095410	479	R>S		No	ClinGen gnomAD
CA387606155 rs1467496727	482	V>D		No	ClinGen gnomAD
rs764158169 CA6921309	484	E>G		No	ClinGen ExAC gnomAD
CA247095387 rs113373326	485	P>L		No	ClinGen Ensembl
CA6921308 rs762898535	485	P>S		No	ClinGen ExAC gnomAD
rs1177235355 CA387606117	488	V>G		No	ClinGen TOPMed
CA387606111 rs1464743769	489	S>Y		No	ClinGen TOPMed
CA6921306 rs766414006	490	F>L		No	ClinGen ExAC gnomAD
CA247095368 rs1050317428	492	F>I		No	ClinGen TOPMed gnomAD
CA387606082 rs1392113973	493	K>R		No	ClinGen gnomAD
CA387606054 rs1593140769	495	W>*		No	ClinGen Ensembl
rs1246795398 CA387606058	495	W>G		No	ClinGen TOPMed
TCGA novel	498	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6921289 rs536417177	498	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1593140766 CA387606016	500	H>R		No	ClinGen Ensembl
rs766419466 CA6921288	501	Q>*		No	ClinGen ExAC gnomAD
CA387606006 rs4312169	501	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1299724359 CA387606000	502	F>C		No	ClinGen TOPMed gnomAD
rs1299724359 CA387606001	502	F>S		No	ClinGen TOPMed gnomAD
rs750462481 CA6921286	504	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA387605989 rs750462481	504	R>G		No	ClinGen ExAC gnomAD
rs923591431 CA247095114	504	R>Q		No	ClinGen TOPMed gnomAD
CA6921284 rs761969841	511	S>C		No	ClinGen ExAC gnomAD
TCGA novel	511	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	512	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774706545 CA6921283	513	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1432941602 CA387605869	514	N>I		No	ClinGen gnomAD
rs767779503 CA6921282	515	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6921281 rs763425454	516	I>T		No	ClinGen ExAC gnomAD
CA387605799 rs1475348458	519	M>T		No	ClinGen gnomAD
CA6921280 rs376021333	522	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1443797848 CA387605724	523	N>K		No	ClinGen gnomAD
CA6921278 CA6921277 rs144582137	525	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1209610157 CA387605705	525	Q>K		No	ClinGen TOPMed gnomAD
rs1215110238 CA387605665	528	K>E		No	ClinGen gnomAD
CA387605648 rs1338593917	529	D>V		No	ClinGen gnomAD
CA387605597 rs1392892050	532	D>V		No	ClinGen TOPMed
CA387605583 rs1593140671	534	E>Q		No	ClinGen Ensembl
rs1566033462 CA387605389	537	I>T		No	ClinGen Ensembl
CA387605395 rs1352483570	537	I>V		No	ClinGen gnomAD
CA6921258 rs776283308	538	K>R		No	ClinGen ExAC gnomAD
CA387605376 rs776283308	538	K>T		No	ClinGen ExAC gnomAD
rs549090116 CA6921257	539	Q>K		No	ClinGen 1000Genomes ExAC
CA387605360 rs1353339690	539	Q>L		No	ClinGen gnomAD
CA6921256 rs373314805	540	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6921255 COSM1477162 rs772892485	540	R>H	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA387605347 rs1270615754	541	K>E		No	ClinGen gnomAD
rs1394234742 CA387605329	542	N>D		No	ClinGen gnomAD
CA387605300 rs1163176147	543	K>N		No	ClinGen gnomAD
CA387605290 rs1474028783	544	Q>R		No	ClinGen TOPMed gnomAD
CA387605266 rs1177345644	546	D>E		No	ClinGen gnomAD
CA6921254 rs771584492	546	D>G		No	ClinGen ExAC gnomAD
rs778518214 CA6921253 COSM271401	547	G>D	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs778518214 CA6921252	547	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1468824974 CA387605207	552	E>*		No	ClinGen gnomAD
rs529419867 CA6921249	555	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1307975343 CA387605137	557	V>F		No	ClinGen gnomAD
CA387605120 rs1223333509	558	H>R		No	ClinGen gnomAD
CA6921248 rs768588132	559	P>L		No	ClinGen ExAC TOPMed gnomAD
CA387605092 rs1370832915	560	E>G		No	ClinGen gnomAD
CA387605055 rs1275506895	563	N>T		No	ClinGen TOPMed gnomAD
CA6921246 rs764403960	563	N>Y		No	ClinGen ExAC gnomAD
CA6921245 rs758497194	565	K>R		No	ClinGen ExAC gnomAD
CA6921244 rs369551344	566	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs765631183 CA6921243	567	S>F		No	ClinGen ExAC TOPMed gnomAD
CA387604973 rs1329576224	569	C>Y		No	ClinGen TOPMed gnomAD
rs1241902796 CA387604929	573	Q>*		No	ClinGen TOPMed
TCGA novel	573	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6921241 rs754381818	577	P>S		No	ClinGen ExAC gnomAD
CA6921238 rs772548446	578	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1191590525 CA387604885	580	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	580	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6921236 rs761308981	581	A>D		No	ClinGen ExAC gnomAD
rs771773145 CA6921237	581	A>T		No	ClinGen ExAC gnomAD
CA6921235 rs774272200	582	L>F		No	ClinGen ExAC gnomAD
rs1280832493 CA387604871	583	R>*		No	ClinGen gnomAD
rs914138599 CA247093546	584	T>A		No	ClinGen Ensembl
TCGA novel	584	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1370994618 CA387604864	584	T>S		No	ClinGen gnomAD
CA6921233 rs749269264	585	I>L		No	ClinGen ExAC gnomAD
CA6921232 rs779932849	585	I>T		No	ClinGen ExAC gnomAD
rs749269264 CA6921234	585	I>V		No	ClinGen ExAC gnomAD
CA6921230 rs747131886	589	S>N		No	ClinGen ExAC TOPMed gnomAD
CA6921229 rs149329660	590	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs755364028 CA6921225	591	A>V		No	ClinGen ExAC gnomAD
CA387604807 rs1400029494	593	N>S		No	ClinGen TOPMed gnomAD
CA6921224 rs544564911	594	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs145967757 CA6921222	596	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs376742718 CA247093476	596	S>R		No	ClinGen ESP TOPMed
rs62619824 CA6921221	599	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs62619824 CA6921220	599	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387604708 rs1259869058	607	P>L		No	ClinGen gnomAD
rs761588107 CA6921217	607	P>S		No	ClinGen ExAC gnomAD
CA387604699 rs1211735436	609	V>L		No	ClinGen gnomAD
rs1211735436 CA387604700	609	V>M		No	ClinGen gnomAD
CA247093445 rs201631122	610	V>I		No	ClinGen 1000Genomes TOPMed gnomAD
CA387604688 rs1323494607	611	S>C		No	ClinGen TOPMed
rs1278220908 CA387604680	612	L>*		No	ClinGen gnomAD
TCGA novel	613	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371735160 CA6921216	615	G>D		No	ClinGen ESP ExAC gnomAD
TCGA novel	618	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6921215 rs768476319	619	M>L		No	ClinGen ExAC gnomAD
rs1295319964 CA387604614	621	C>*		No	ClinGen gnomAD

No associated diseases with Q9Y217

1 regional properties for Q9Y217

Type	Name	Position	InterPro Accession
domain	Transcription factor CBF/NF-Y/archaeal histone domain	9 - 73	IPR003958

Functions

		Description
EC Number	3.1.3.64	Phosphoric monoester hydrolases
Subcellular Localization	Cytoplasm Endoplasmic reticulum-Golgi intermediate compartment Endoplasmic reticulum Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, perinuclear region	Localizes to ruffles during EGF-induced macropinocytosis (By similarity) Colocalizes with MTMR9 to the perinuclear region (PubMed:19038970) Partially localizes to the endoplasmic reticulum (PubMed:19038970) Co-localizes with RAB1B to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum-Golgi intermediate compartment	A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
ruffle membrane	The portion of the plasma membrane surrounding a ruffle.

5 GO annotations of molecular function

Name	Definition
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.
phosphatidylinositol-3,5-bisphosphate phosphatase activity	Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.
phosphatidylinositol-3-phosphatase activity	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.
protein serine/threonine phosphatase activity	Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
protein tyrosine phosphatase activity	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

4 GO annotations of biological process

Name	Definition
endocytosis	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
phosphatidylinositol biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
phosphatidylinositol dephosphorylation	The process of removing one or more phosphate groups from a phosphatidylinositol.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5F452	MTMR8	Myotubularin-related protein 8	Gallus gallus (Chicken)	PR
Q86WG5	SBF2	Myotubularin-related protein 13	Homo sapiens (Human)	PR
O95248	SBF1	Myotubularin-related protein 5	Homo sapiens (Human)	PR
Q13613	MTMR1	Myotubularin-related protein 1	Homo sapiens (Human)	PR
Q13496	MTM1	Myotubularin	Homo sapiens (Human)	PR
Q13614	MTMR2	Myotubularin-related protein 2	Homo sapiens (Human)	PR
Q96QG7	MTMR9	Myotubularin-related protein 9	Homo sapiens (Human)	PR
Q9Y216	MTMR7	Myotubularin-related protein 7	Homo sapiens (Human)	PR
Q9Z2C9	Mtmr7	Myotubularin-related protein 7	Mus musculus (Mouse)	PR
A2BGG1	mtmr12	Myotubularin-related protein 12	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MEHIRTTKVE	QVKLLDRFST	SNKSLTGTLY	LTATHLLFID	SHQKETWILH	HHIASVEKLA
70	80	90	100	110	120
LTTSGCPLVI	QCKNFRTVHF	IVPRERDCHD	IYNSLLQLSK	QAKYEDLYAF	SYNPKQNDSE
130	140	150	160	170	180
RLQGWQLIDL	AEEYKRMGVP	NSHWQLSDAN	RDYKICETYP	RELYVPRIAS	KPIIVGSSKF
190	200	210	220	230	240
RSKGRFPVLS	YYHQDKEAAI	CRCSQPLSGF	SARCLEDEHL	LQAISKANPV	NRYMYVMDTR
250	260	270	280	290	300
PKLNAMANRA	AGKGYENEDN	YSNIRFQFVG	IENIHVMRSS	LQKLLEVNGT	KGLSVNDFYS
310	320	330	340	350	360
GLESSGWLRH	IKAVMDAAIF	LAKAITVENA	SVLVHCSDGW	DRTSQVCSLG	SLLLDSYYRT
370	380	390	400	410	420
IKGFMVLIEK	DWISFGHKFS	ERCGQLDGDP	KEVSPVFTQF	LECVWHLTEQ	FPQAFEFSEA
430	440	450	460	470	480
FLLQIHEHIH	SCQFGNFLGN	CQKEREELKL	KEKTYSLWPF	LLEDQKKYLN	PLYSSESHRF
490	500	510	520	530	540
TVLEPNTVSF	NFKFWRNMYH	QFDRTLHPRQ	SVFNIIMNMN	EQNKQLEKDI	KDLESKIKQR
550	560	570	580	590	600
KNKQTDGILT	KELLHSVHPE	SPNLKTSLCF	KEQTLLPVND	ALRTIEGSSP	ADNRYSEYAE
610	620
EFSKSEPAVV	SLEYGVARMT	C