Q5F452

PR
Gene name
MTMR8 (RCJMB04_3d12)
Protein name
Myotubularin-related protein 8
Names
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:422312
EC number
3.1.3.64: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

574-629 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5F452

Entry ID Method Resolution Chain Position Source
AF-Q5F452-F1 Predicted AlphaFoldDB

No variants for Q5F452

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5F452

No associated diseases with Q5F452

4 regional properties for Q5F452

Type Name Position InterPro Accession
domain Protein-tyrosine phosphatase, catalytic 264 - 432 IPR003595
domain Myotubularin-like, phosphatase domain 109 - 500 IPR010569
active_site Protein-tyrosine phosphatase, active site 336 - 346 IPR016130
domain Myotubularin-related protein 8, protein tyrosine phosphatase domain 126 - 433 IPR030591

Functions

Description
EC Number 3.1.3.64 Phosphoric monoester hydrolases
Subcellular Localization
  • Nucleus envelope
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

3 GO annotations of molecular function

Name Definition
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.
phosphatidylinositol-3,5-bisphosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.
phosphatidylinositol-3-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.

2 GO annotations of biological process

Name Definition
negative regulation of autophagy Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
phosphatidylinositol dephosphorylation The process of removing one or more phosphate groups from a phosphatidylinositol.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y216 MTMR7 Myotubularin-related protein 7 Homo sapiens (Human) PR
Q96QG7 MTMR9 Myotubularin-related protein 9 Homo sapiens (Human) PR
Q9Y217 MTMR6 Myotubularin-related protein 6 Homo sapiens (Human) PR
Q9Z2C9 Mtmr7 Myotubularin-related protein 7 Mus musculus (Mouse) PR
A2BGG1 mtmr12 Myotubularin-related protein 12 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEHITTPKVE NVKLLDRYTN RKAASGTLYL TATHLIYVDA SAEVRKETWI LHHHIATVEK
70 80 90 100 110 120
LPLTTAGCPL LIHCKNFHVA HFVIGQERDC HEVYTSLLKL SQPVKPEELY AFSYNPKMSK
130 140 150 160 170 180
DNREIGWKLI DLKVDYQRMG IPNDYWEITD LNKDYEVCNT YPPEIVVPRA ASKATVIGSS
190 200 210 220 230 240
RFRSRGRIPV LSYLYKENNA AICRCSQPLS GFSARCLEDE QMLQAIREAN PGSPFMYVVD
250 260 270 280 290 300
TRPKLNAMAN RAAGKGYENE DNYDNIRFKF IGIENIHVMR SSLQKLLEVC ETKSPSMSDF
310 320 330 340 350 360
LTGLENSGWL RHIKAVMDAS VFLAKAVKDE KASVLVHCSD GWDRTAQVCS LASLLLDPFY
370 380 390 400 410 420
RAFKGFMVLI EKEWIAMGHK FSHRCGHLDG DPKEVSPVFT QFIECVWQLM QQFPCTFEFN
430 440 450 460 470 480
EHFLLEIHDH VYSCQFGNFL GTCHKEREDL KIFEKTHSLW PFLLQKKQEL RNPLYRGFTA
490 500 510 520 530 540
YKELQPNTLP FSFQFWCGMY NRFDKGMHPK QCVLDHLLSC MNQKIKLEDN ASELENKLPF
550 560 570 580 590 600
LDGPLPNEAC FLSKVGCAAS KTPMLNTPQD YEGEAPPVLT NGISVGDINV TSDVDQRNKE
610 620
NLANHRDLHL NDSVDVLNSE AKDGKPQHH