A2BGG1
Gene name |
mtmr12 (si:dkey-207e22.3) |
Protein name |
Myotubularin-related protein 12 |
Names |
Inactive phosphatidylinositol 3-phosphatase 12 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:569130 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2BGG1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2BGG1-F1 | Predicted | AlphaFoldDB |
No variants for A2BGG1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2BGG1 | |||||
No associated diseases with A2BGG1
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| sarcomere | The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
| sarcoplasmic reticulum | A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatase regulator activity | Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. |
| phosphatidylinositol-3-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| locomotory behavior | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. |
| phosphatidylinositol dephosphorylation | The process of removing one or more phosphate groups from a phosphatidylinositol. |
| skeletal muscle fiber development | The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5F452 | MTMR8 | Myotubularin-related protein 8 | Gallus gallus (Chicken) | PR |
| Q9Y216 | MTMR7 | Myotubularin-related protein 7 | Homo sapiens (Human) | PR |
| Q96QG7 | MTMR9 | Myotubularin-related protein 9 | Homo sapiens (Human) | PR |
| Q9Y217 | MTMR6 | Myotubularin-related protein 6 | Homo sapiens (Human) | PR |
| Q9Z2C9 | Mtmr7 | Myotubularin-related protein 7 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLSLGSGGAK | SSKPSFVSYV | TPEEIKLEKD | PQKKEKHPDL | LPGEVVFCSA | NPILKYTQDD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LSQRGVFGTL | LCTNFRVAFI | SDDAPQEEMS | KTFKNKLYGE | NDIPLMCVDH | IYGVYDEKRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LITGGLVKNK | CPSKMIIHCK | DLRVFQFCLT | FSKEEDAKRI | FQGIAHHCLE | EKSLKCVFAF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SYLRSTNPEM | LRKREAIMFD | SPEDWTQEMK | RTKAQCRLVT | ENENFELSQR | LPQYFVIPSA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LGDLFNYQGK | GLPIWCWSHH | SGCALFKASF | PSMTQEDGDF | QSHLDTMITA | VARNYLYSVK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TEDLSESLPT | LQDIQQSYNK | FKQYFLIDNT | TDFWLSDVKW | FSSLESSGWL | DIIRQCLQKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VEVVECLEKD | NTNVLITEEE | GTDLCCVISS | LAQIMLDPYY | RTLMGFQSLV | QKEWVAGCHA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FLDRCNHLHQ | KDKECHSPVF | LLFLECVWQL | VQQHSPAFQF | SETYLTVLSD | SVHVPIFSTF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LFNSAHHRES | VMKAESPIAQ | SRPLSCPTVW | DWSVQFDSKA | QNFFFNPLYS | EKVKHERTVR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RPHKHKHQRQ | LSLPSSAFKT | PTKKGFFKDE | TDSLKKMLRV | KRISRWMGSP | DSPVVASREF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YESWQQRPLD | YHGLLLPSLD | GPSVRIWMQR | YLRWIPEVHI | MGGGSVAIMT | KLMELLSQVE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DLKRVLEQRD | PSLATQPDHP | PPLHHRLPSF | GSSGRLSSSF | PFTYSRNRSF | KPIIPTGLMQ |
| 730 | |||||
| SLMVADNLAN | QEDETS |