Q9Z2C4
Gene name |
Mtmr1 |
Protein name |
Myotubularin-related protein 1 |
Names |
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:53332 |
EC number |
3.1.3.64: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z2C4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z2C4-F1 | Predicted | AlphaFoldDB |
26 variants for Q9Z2C4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3408312036 | 55 | T>I | No | EVA | |
| rs3389571489 | 127 | V>E | No | EVA | |
| rs3410985356 | 172 | N>K | No | EVA | |
| rs3409278737 | 221 | N>S | No | EVA | |
| rs29042423 | 249 | S>C | No | EVA | |
| rs3410664109 | 288 | A>S | No | EVA | |
| rs3410985426 | 291 | R>C | No | EVA | |
| rs3411243260 | 311 | Q>H | No | EVA | |
| rs3410243328 | 317 | N>T | No | EVA | |
| rs3411243327 | 318 | D>N | No | EVA | |
| rs3410509325 | 364 | N>V | No | EVA | |
| rs3389518405 | 372 | E>* | No | EVA | |
| rs3409813911 | 402 | S>P | No | EVA | |
| rs3410509304 | 405 | L>I | No | EVA | |
| rs3410823074 | 406 | S>A | No | EVA | |
| rs3410509301 | 419 | V>I | No | EVA | |
| rs3389571632 | 432 | E>V | No | EVA | |
| rs3389558105 | 466 | T>S | No | EVA | |
| rs3389556962 | 496 | H>L | No | EVA | |
| rs3389555173 | 499 | A>P | No | EVA | |
| rs3410614252 | 522 | A>T | No | EVA | |
| rs3389571623 | 619 | H>L | No | EVA | |
| rs3389563158 | 624 | E>G | No | EVA | |
| rs3410664092 | 636 | V>M | No | EVA | |
| rs3389511201 | 637 | E>G | No | EVA | |
| rs3410768274 | 640 | Q>* | No | EVA |
No associated diseases with Q9Z2C4
7 regional properties for Q9Z2C4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Tyrosine-specific protein phosphatases domain | 411 - 473 | IPR000387 |
| domain | Protein-tyrosine phosphatase, catalytic | 390 - 538 | IPR003595 |
| domain | GRAM domain | 97 - 210 | IPR004182 |
| domain | Myotubularin-like, phosphatase domain | 217 - 605 | IPR010569 |
| active_site | Protein-tyrosine phosphatase, active site | 440 - 450 | IPR016130 |
| domain | Myotubularin-related protein 1, protein tyrosine phosphatase domain | 290 - 538 | IPR030587 |
| domain | MTMR1, PH-GRAM | 111 - 210 | IPR037857 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.64 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. |
| phosphatidylinositol-3-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidylinositol dephosphorylation | The process of removing one or more phosphate groups from a phosphatidylinositol. |
| regulation of phosphatidylinositol dephosphorylation | Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q13613 | MTMR1 | Myotubularin-related protein 1 | Homo sapiens (Human) | PR |
| Q9Z2C5 | Mtm1 | Myotubularin | Mus musculus (Mouse) | PR |
| Q9Z2D1 | Mtmr2 | Myotubularin-related protein 2 | Mus musculus (Mouse) | PR |
| Q9Z2C9 | Mtmr7 | Myotubularin-related protein 7 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRPVAAAAA | ASAASCEGAG | GPGPGPGASW | RPSRVAGGAS | ASSRHPSIET | LDSPTGSHVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WCKQLIAATI | SSQISGSVTS | ENVSRDYKAL | RDGNKLAQME | EAPLFPGESI | KAIVKDVIYI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CPFMGAVSGT | LTVTDFKMYF | KNVERDPHFV | LDVPLGVISR | VEKIGAQSHG | DNSCGIEIVC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KDMRNLRLAY | KQEEQRKLGI | FENLNKHAFP | LSNGQVLFAF | NYKEKFPVNG | WKVYDPVSEY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KRQGLPNESW | KISKINSNYE | FCDTYPAIIV | VPTSVKDDDL | SKVAAFRAKG | RVPVLSWIHP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESQATITRCS | QPLVGPNDKR | CKEDEKYLQT | IMDANAQSHK | LTIFDARQNS | VADTNKAKGG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GYENESAYPN | AELIFLEIHN | IHVMRESLRK | LKEIVYPSID | ESHWLSNVDG | THWLEYIRVL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LAGAVRIADK | IESGKTSVVI | HCSDGWDRTS | QLTSLAMLML | DSYYRTIKGF | EALIEKEWIS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FGHRFALRVG | HGDDNHADAD | RSPIFLQFID | CVWQMTRQFP | SAFEFNELFL | ITILDHLYSC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LFGTFLCNCE | QQRIKEDVYT | NTISLWSYIN | SQLDEFSNPF | FVNYENHVLY | PVASMSHLEL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| WVNYYVRWNP | RMRPQMPIHQ | NLKELLAIKA | ELQKRVEDLQ | REMATRTISS | SSERGSSPTH |
| SATPVHTSV |