Q9WTT2

PR
Gene name
Clpb (Skd3)
Protein name
Caseinolytic peptidase B protein homolog
Names
Suppressor of potassium transport defect 3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:65041
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

613-677 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9WTT2

Entry ID Method Resolution Chain Position Source
AF-Q9WTT2-F1 Predicted AlphaFoldDB

No variants for Q9WTT2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9WTT2

No associated diseases with Q9WTT2

9 regional properties for Q9WTT2

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 423 - 646 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1211 - 1444 IPR003439-2
domain AAA+ ATPase domain 450 - 639 IPR003593-1
domain AAA+ ATPase domain 1237 - 1419 IPR003593-2
domain ABC transporter type 1, transmembrane domain 82 - 350 IPR011527-1
domain ABC transporter type 1, transmembrane domain 860 - 1158 IPR011527-2
conserved_site ABC transporter-like, conserved site 548 - 562 IPR017871
domain CFTR regulator domain 639 - 849 IPR025837
domain Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1 389 - 670 IPR047082

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion intermembrane space
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

3 GO annotations of biological process

Name Definition
antiviral innate immune response A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
RIG-I signaling pathway The series of molecular signals initiated by the binding of viral RNA to a pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I is a cytoplasmic receptor that detects RNA synthesized during viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0ABH9 clpA ATP-dependent Clp protease ATP-binding subunit ClpA Escherichia coli (strain K12) PR
Q60649 Clpb Caseinolytic peptidase B protein homolog Mus musculus (Mouse) PR
Q7F9I1 CLPC1 Chaperone protein ClpC1, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q53LY0 CLPC3 Chaperone protein ClpC3, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q2QVG9 CLPC2 Chaperone protein ClpC2, chloroplastic Oryza sativa subsp japonica (Rice) PR
P42730 CLPB1 Chaperone protein ClpB1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXJ7 CLPC2 Chaperone protein ClpC2, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9FI56 CLPC1 Chaperone protein ClpC1, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
P31541 CD4A ATP-dependent Clp protease ATP-binding subunit ClpA homolog CD4A, chloroplastic Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P31542 CD4B ATP-dependent Clp protease ATP-binding subunit ClpA homolog CD4B, chloroplastic Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MMLSAVLRRT APAPRLFLGL IKSPSLQSRG GAYNRSVITG DRGEPQRLRT AAWVRPGASS
70 80 90 100 110 120
VLFPGRGAAT GGRRGERTEI PYLTAASSGR GPSPEETLPG QDSWNGVPNK AGLGMWALAM
130 140 150 160 170 180
ALVVQCYNKN PSNKDAALME AARANNVQEV RRLLSEGADV NARHKLGWTA LMVAAISHNE
190 200 210 220 230 240
SVVQVLLAAG ADPNLGDDFS SVYKTANEQG VHSLEVLVTR EDDFNNRLNH RASFKGCTAL
250 260 270 280 290 300
HYAVLADDYS IVKELLGGGA NPLQRNEMGH TPLDYAREGE VMKLLKTSET KYMEKQRKRE
310 320 330 340 350 360
AEERRRFPLE QRLEQHIIGQ ESAIATVGAA IRRKENGWYD EEHPLVFLFL GSSGIGKTEL
370 380 390 400 410 420
AKQTAKYMHK DAKKGFIRLD MSEFQERHEV AKFIGSPPGY IGHEEGGQLT KKLKQCPNAV
430 440 450 460 470 480
VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK GKTIDCKDAI FIMTSNVASD EIAQHALQLR
490 500 510 520 530 540
QEALEMSRNR IAENLGDVQI SDKITISKNF KENMIRPILK AHFRRDEFLG RINEIVYFLP
550 560 570 580 590 600
FCHSELIQLV NKELNFWAKR AKQRHNITLL WDREVADVLV DGYNVQYGAR SIKHEVERRV
610 620 630 640 650 660
VNQLAAAYEQ DLLPGGCTLR ITVEDSDKQL LKSPELPSPQ AEKRPPTLRL EIIDKDSKTH
670
KLDIQAPLHP EKVCYTI