Q60649

PR
Gene name
Clpb (Skd3)
Protein name
Caseinolytic peptidase B protein homolog
Names
Suppressor of potassium transport defect 3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20480
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

611-677 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q60649

Entry ID Method Resolution Chain Position Source
AF-Q60649-F1 Predicted AlphaFoldDB

19 variants for Q60649

Variant ID(s) Position Change Description Diseaes Association Provenance
rs31817744 37 V>I No EVA
rs250799153 87 S>L No EVA
rs227657164 102 D>E No EVA
rs3388928828 108 P>T No EVA
rs3397934645 174 A>P No EVA
rs3398088062 185 V>D No EVA
rs3388913840 218 V>A No EVA
rs3388918702 274 D>Y No EVA
rs3388923025 280 E>K No EVA
rs3388923086 328 G>D No EVA
rs3388932802 392 K>M No EVA
rs3388929083 414 K>N No EVA
rs3388932728 487 S>N No EVA
rs3388909452 522 H>Y No EVA
rs3398337714 585 V>F No EVA
rs3388928865 627 D>G No EVA
rs3388925060 666 A>T No EVA
rs3388902657 674 C>Y No EVA
rs3388929248 675 Y>H No EVA

No associated diseases with Q60649

5 regional properties for Q60649

Type Name Position InterPro Accession
repeat Ankyrin repeat 128 - 198 IPR002110-1
repeat Ankyrin repeat 235 - 276 IPR002110-2
domain AAA+ ATPase domain 343 - 497 IPR003593
domain ATPase, AAA-type, core 346 - 535 IPR003959
domain Clp ATPase, C-terminal 541 - 630 IPR019489

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion intermembrane space
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

3 GO annotations of biological process

Name Definition
antiviral innate immune response A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
RIG-I signaling pathway The series of molecular signals initiated by the binding of viral RNA to a pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I is a cytoplasmic receptor that detects RNA synthesized during viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0ABH9 clpA ATP-dependent Clp protease ATP-binding subunit ClpA Escherichia coli (strain K12) PR
Q9WTT2 Clpb Caseinolytic peptidase B protein homolog Rattus norvegicus (Rat) PR
Q7F9I1 CLPC1 Chaperone protein ClpC1, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q53LY0 CLPC3 Chaperone protein ClpC3, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q2QVG9 CLPC2 Chaperone protein ClpC2, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q9SXJ7 CLPC2 Chaperone protein ClpC2, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
P42730 CLPB1 Chaperone protein ClpB1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FI56 CLPC1 Chaperone protein ClpC1, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
P31541 CD4A ATP-dependent Clp protease ATP-binding subunit ClpA homolog CD4A, chloroplastic Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P31542 CD4B ATP-dependent Clp protease ATP-binding subunit ClpA homolog CD4B, chloroplastic Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MMLSAVLRRT TPAPRLFLGL IKSPSLQSRG GAYGRGVVTG DRGEPQRLRA AAWVRPGASS
70 80 90 100 110 120
TFVPGRGAAT WGRRGERTEI PYLTAASSER GPSPEETLPG QDSWNGVPNK TGLGMWALAM
130 140 150 160 170 180
ALVVQCYSKN PSNKDAALME AARANNVQEV RRLLSEGADV NARHKLGWTA LMVASISHNE
190 200 210 220 230 240
SVVQVLLAAG ADPNLGDEFS SVYKTANEQG VHSLEVLVTR EDDFNNRLNH RASFKGCTAL
250 260 270 280 290 300
HYAVLADDYS IVKELLDRGA NPLQRNEMGH TPLDYAREGE VMKLLKTSET KYMEKQRKRE
310 320 330 340 350 360
AEERRRFPLE QRLKEHIIGQ ESAIATVGAA IRRKENGWYD EEHPLVFLFL GSSGIGKTEL
370 380 390 400 410 420
AKQTAKYMHK DAKKGFIRLD MSEFQERHEV AKFIGSPPGY IGHEEGGQLT KKLKQCPNAV
430 440 450 460 470 480
VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK GKTIDCKDAI FIMTSNVASD EIAQHALQLR
490 500 510 520 530 540
QEALEMSRNR IAENLGDVQM SDKITISKNF KENVIRPILK AHFRRDEFLG RINEIVYFLP
550 560 570 580 590 600
FCHSELIQLV NKELNFWAKR AKQRHNITLL WDREVADVLV DGYNVHYGAR SIKHEVERRV
610 620 630 640 650 660
VNQLAAAYEQ DLLPGGCTLR ITVEDSDKHL LKSPELPSPQ AEKRPPTLRL EIIDKDSKTR
670
KLDIQAPLHP EKVCYTI