AiPD: Autoinhibited Protein Database

Gene name	clpA (lopD, b0882, JW0866)
Protein name	ATP-dependent Clp protease ATP-binding subunit ClpA
Names
Species	Escherichia coli (strain K12)
KEGG Pathway	eco:b0882
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

114-193 (Predicted disordered autoinhibitory region) PR

114-193 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1K6K	X-ray	180 A	A	1-143	PDB
1KSF	X-ray	260 A	X	1-758	PDB
1LZW	X-ray	250 A	B	1-146	PDB
1MBU	X-ray	230 A	A/B	1-142	PDB
1MBV	X-ray	330 A	A	1-142	PDB
1MBX	X-ray	225 A	A/B	1-142	PDB
1MG9	X-ray	230 A	B	1-146	PDB
1R6B	X-ray	225 A	X	1-758	PDB
1R6C	X-ray	215 A	X	1-143	PDB
1R6O	X-ray	225 A	A/B	1-143	PDB
1R6Q	X-ray	235 A	A/B	1-143	PDB
5OFO	EM	460 A	A/B/C/D/E/F	609-635	PDB
5OG1	EM	450 A	A/B/C/D/E/F	609-635	PDB
6UQE	EM	300 A	A/B/C/D/E/F	169-746	PDB
6UQO	EM	310 A	A/B/C/D/E/F	169-746	PDB
6W1Z	EM	270 A	A/B/C/D/E/F	1-758	PDB
6W20	EM	300 A	A/B/C/D/E/F	1-758	PDB
6W21	EM	330 A	A/B/C/D/E/F	1-758	PDB
6W22	EM	300 A	A/B/C/D/E/F	1-758	PDB
6W23	EM	310 A	A/B/C/D/E/F	1-758	PDB
6W24	EM	340 A	A/B/C/D/E/F	1-758	PDB
7UIV	EM	338 A	A/B/C/D/E/F	1-758	PDB
7UIW	EM	333 A	A/B/C/D/E/F	1-758	PDB
7UIX	EM	324 A	A/B/C/D/E/F	1-758	PDB
7UIY	EM	322 A	A/B/C/D/E/F	1-758	PDB
7UIZ	EM	324 A	A/B/C/D/E/F	1-758	PDB
7UJ0	EM	326 A	A/B/C/D/E/F	1-758	PDB
AF-P0ABH9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P0ABH9

Type	Name	Position	InterPro Accession
domain	AAA+ ATPase domain	206 - 352	IPR003593-1
domain	AAA+ ATPase domain	487 - 654	IPR003593-2
domain	ATPase, AAA-type, core	211 - 342	IPR003959-1
domain	ATPase, AAA-type, core	486 - 647	IPR003959-2
domain	Clp, repeat (R) domain	1 - 145	IPR004176
conserved_site	ClpA/B, conserved site 1	302 - 314	IPR018368
domain	Clp ATPase, C-terminal	653 - 744	IPR019489
conserved_site	ClpA/B, conserved site 2	518 - 536	IPR028299
domain	ClpA/ClpB, AAA lid domain	350 - 452	IPR041546

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endopeptidase Clp complex	A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent peptidase activity	Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis.

Name	Definition
cellular response to heat	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
protein quality control for misfolded or incompletely synthesized proteins	The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.
protein unfolding	The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
response to oxidative stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q60649	Clpb	Caseinolytic peptidase B protein homolog	Mus musculus (Mouse)	PR
Q9WTT2	Clpb	Caseinolytic peptidase B protein homolog	Rattus norvegicus (Rat)	PR
P42730	CLPB1	Chaperone protein ClpB1	Arabidopsis thaliana (Mouse-ear cress)	PR