P42730
PR
Gene name |
CLPB1 (DLT1) |
Protein name |
Chaperone protein ClpB1 |
Names |
ATP-dependent Clp protease ATP-binding subunit ClpB homolog 1, Casein lytic proteinase B1, Heat shock protein 101, Protein DEFECTIVE IN LONG-TERM ACQUIRED THERMOTOLERANCE |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G74310 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P42730
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P42730-F1 | Predicted | AlphaFoldDB |
43 variants for P42730
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH01535073 | 17 | A>S | No | 1000Genomes | |
| tmp_1_27939692_G_T | 57 | N>K | No | 1000Genomes | |
| tmp_1_27939688_C_A | 59 | A>S | No | 1000Genomes | |
| ENSVATH05143822 | 63 | E>G | No | 1000Genomes | |
| tmp_1_27939622_C_A | 81 | D>Y | No | 1000Genomes | |
| tmp_1_27939582_C_A | 94 | R>L | No | 1000Genomes | |
| tmp_1_27939517_C_A | 116 | G>C | No | 1000Genomes | |
| ENSVATH14478667 | 133 | A>G | No | 1000Genomes | |
| tmp_1_27939435_T_G | 143 | K>T | No | 1000Genomes | |
| tmp_1_27939420_T_C | 148 | E>G | No | 1000Genomes | |
| ENSVATH05143820 | 152 | V>I | No | 1000Genomes | |
| ENSVATH05143817 | 192 | V>A | No | 1000Genomes | |
| ENSVATH00142526 | 269 | D>E | No | 1000Genomes | |
| tmp_1_27939055_C_T | 270 | A>T | No | 1000Genomes | |
| ENSVATH14478666 | 271 | E>G | No | 1000Genomes | |
| tmp_1_27938941_G_T | 308 | Q>K | No | 1000Genomes | |
| tmp_1_27938881_C_T | 328 | A>T | No | 1000Genomes | |
| tmp_1_27938715_G_A | 383 | T>I | No | 1000Genomes | |
| tmp_1_27938523_T_A | 419 | K>M | No | 1000Genomes | |
| ENSVATH05143813 | 443 | I>V | No | 1000Genomes | |
| tmp_1_27938447_C_A | 444 | E>D | No | 1000Genomes | |
| tmp_1_27938303_G_A | 446 | R>W | No | 1000Genomes | |
| tmp_1_27938237_C_T | 468 | E>K | No | 1000Genomes | |
| tmp_1_27938215_C_T | 475 | R>K | No | 1000Genomes | |
| ENSVATH01535051 | 480 | R>K | No | 1000Genomes | |
| ENSVATH05143808 | 522 | S>F | No | 1000Genomes | |
| ENSVATH14478665 | 569 | K>N | No | 1000Genomes | |
| ENSVATH14478664 | 622 | Q>K | No | 1000Genomes | |
| ENSVATH13807186 | 644 | V>I | No | 1000Genomes | |
| tmp_1_27937517_C_T | 680 | V>M | No | 1000Genomes | |
| tmp_1_27937487_T_G | 690 | T>P | No | 1000Genomes | |
| ENSVATH05143803 | 731 | T>S | No | 1000Genomes | |
| tmp_1_27937287_C_G | 756 | L>F | No | 1000Genomes | |
| tmp_1_27937229_C_T | 776 | V>I | No | 1000Genomes | |
| ENSVATH00142517 | 798 | T>A | No | 1000Genomes | |
| tmp_1_27937144_T_G | 804 | Y>S | No | 1000Genomes | |
| tmp_1_27936948_C_T | 835 | V>I | No | 1000Genomes | |
| ENSVATH14478661 | 847 | Y>N | No | 1000Genomes | |
| tmp_1_27936903_C_T | 850 | A>T | No | 1000Genomes | |
| ENSVATH13807180 | 853 | G>D | No | 1000Genomes | |
| tmp_1_27936817_A_T | 878 | H>Q | No | 1000Genomes | |
| tmp_1_27936794_C_T | 886 | S>N | No | 1000Genomes | |
| ENSVATH04081801 | 912 | D>Y | No | 1000Genomes |
No associated diseases with P42730
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to heat | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| cellular response to hypoxia | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| positive regulation of translation | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| protein unfolding | The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. |
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P0ABH9 | clpA | ATP-dependent Clp protease ATP-binding subunit ClpA | Escherichia coli (strain K12) | PR |
| Q60649 | Clpb | Caseinolytic peptidase B protein homolog | Mus musculus (Mouse) | PR |
| Q9WTT2 | Clpb | Caseinolytic peptidase B protein homolog | Rattus norvegicus (Rat) | PR |
| Q7F9I1 | CLPC1 | Chaperone protein ClpC1, chloroplastic | Oryza sativa subsp japonica (Rice) | PR |
| Q53LY0 | CLPC3 | Chaperone protein ClpC3, chloroplastic | Oryza sativa subsp japonica (Rice) | PR |
| Q2QVG9 | CLPC2 | Chaperone protein ClpC2, chloroplastic | Oryza sativa subsp japonica (Rice) | PR |
| Q9SXJ7 | CLPC2 | Chaperone protein ClpC2, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FI56 | CLPC1 | Chaperone protein ClpC1, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P31541 | CD4A | ATP-dependent Clp protease ATP-binding subunit ClpA homolog CD4A, chloroplastic | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P31542 | CD4B | ATP-dependent Clp protease ATP-binding subunit ClpA homolog CD4B, chloroplastic | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNPEKFTHKT | NETIATAHEL | AVNAGHAQFT | PLHLAGALIS | DPTGIFPQAI | SSAGGENAAQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SAERVINQAL | KKLPSQSPPP | DDIPASSSLI | KVIRRAQAAQ | KSRGDTHLAV | DQLIMGLLED |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SQIRDLLNEV | GVATARVKSE | VEKLRGKEGK | KVESASGDTN | FQALKTYGRD | LVEQAGKLDP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIGRDEEIRR | VVRILSRRTK | NNPVLIGEPG | VGKTAVVEGL | AQRIVKGDVP | NSLTDVRLIS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDMGALVAGA | KYRGEFEERL | KSVLKEVEDA | EGKVILFIDE | IHLVLGAGKT | EGSMDAANLF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPMLARGQLR | CIGATTLEEY | RKYVEKDAAF | ERRFQQVYVA | EPSVPDTISI | LRGLKEKYEG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HHGVRIQDRA | LINAAQLSAR | YITGRHLPDK | AIDLVDEACA | NVRVQLDSQP | EEIDNLERKR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MQLEIELHAL | EREKDKASKA | RLIEVRKELD | DLRDKLQPLT | MKYRKEKERI | DEIRRLKQKR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EELMFSLQEA | ERRYDLARAA | DLRYGAIQEV | ESAIAQLEGT | SSEENVMLTE | NVGPEHIAEV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VSRWTGIPVT | RLGQNEKERL | IGLADRLHKR | VVGQNQAVNA | VSEAILRSRA | GLGRPQQPTG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SFLFLGPTGV | GKTELAKALA | EQLFDDENLL | VRIDMSEYME | QHSVSRLIGA | PPGYVGHEEG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GQLTEAVRRR | PYCVILFDEV | EKAHVAVFNT | LLQVLDDGRL | TDGQGRTVDF | RNSVIIMTSN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LGAEHLLAGL | TGKVTMEVAR | DCVMREVRKH | FRPELLNRLD | EIVVFDPLSH | DQLRKVARLQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| MKDVAVRLAE | RGVALAVTDA | ALDYILAESY | DPVYGARPIR | RWMEKKVVTE | LSKMVVREEI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DENSTVYIDA | GAGDLVYRVE | SGGLVDASTG | KKSDVLIHIA | NGPKRSDAAQ | AVKKMRIEEI |
| 910 | |||||
| EDDDNEEMIE | D |