Q9FI56

PR
Gene name
CLPC1
Protein name
Chaperone protein ClpC1, chloroplastic
Names
ATP-dependent Clp protease ATP-binding subunit ClpC homolog 1, Casein lytic proteinase C1, Protein DE-REGULATED CAO ACCUMULATION 1, Protein IRON-RESCUED MUTANT 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G50920
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9FI56

Entry ID Method Resolution Chain Position Source
5GUI X-ray 120 A A 94-238 PDB
AF-Q9FI56-F1 Predicted AlphaFoldDB

4 variants for Q9FI56

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_20719733_A_G 23 V>A No 1000Genomes
tmp_5_20719601_C_T 67 S>N No 1000Genomes
tmp_5_20719568_G_A 78 A>V No 1000Genomes
ENSVATH12691511 835 E>Q No 1000Genomes

No associated diseases with Q9FI56

10 regional properties for Q9FI56

Type Name Position InterPro Accession
domain UVR domain 511 - 546 IPR001943
domain AAA+ ATPase domain 294 - 434 IPR003593-1
domain AAA+ ATPase domain 637 - 818 IPR003593-2
domain ATPase, AAA-type, core 299 - 415 IPR003959-1
domain ATPase, AAA-type, core 636 - 810 IPR003959-2
domain Clp, repeat (R) domain 95 - 237 IPR004176
conserved_site ClpA/B, conserved site 1 389 - 401 IPR018368
domain Clp ATPase, C-terminal 817 - 907 IPR019489
conserved_site ClpA/B, conserved site 2 671 - 689 IPR028299
domain ClpA/ClpB, AAA lid domain 437 - 538 IPR041546

Functions

Description
EC Number
Subcellular Localization
  • Plastid, chloroplast stroma
  • Plastid, chloroplast membrane
  • The membrane association is important for the in vivo functions
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast envelope The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
chloroplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma.
chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
plastid stroma The proteinaceous ground substance of plastids.
Tic complex The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent peptidase activity Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

4 GO annotations of biological process

Name Definition
chloroplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast.
protein import into chloroplast stroma The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import.
protein targeting to chloroplast The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved.
regulation of chlorophyll biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q60649 Clpb Caseinolytic peptidase B protein homolog Mus musculus (Mouse) PR
Q9WTT2 Clpb Caseinolytic peptidase B protein homolog Rattus norvegicus (Rat) PR
Q2QVG9 CLPC2 Chaperone protein ClpC2, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q53LY0 CLPC3 Chaperone protein ClpC3, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q7F9I1 CLPC1 Chaperone protein ClpC1, chloroplastic Oryza sativa subsp japonica (Rice) PR
P42730 CLPB1 Chaperone protein ClpB1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXJ7 CLPC2 Chaperone protein ClpC2, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
P31541 CD4A ATP-dependent Clp protease ATP-binding subunit ClpA homolog CD4A, chloroplastic Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P31542 CD4B ATP-dependent Clp protease ATP-binding subunit ClpA homolog CD4B, chloroplastic Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MAMATRVLAQ STPPSLACYQ RNVPSRGSGR SRRSVKMMCS QLQVSGLRMQ GFMGLRGNNA
70 80 90 100 110 120
LDTLGKSRQD FHSKVRQAMN VPKGKASRFT VKAMFERFTE KAIKVIMLAQ EEARRLGHNF
130 140 150 160 170 180
VGTEQILLGL IGEGTGIAAK VLKSMGINLK DARVEVEKII GRGSGFVAVE IPFTPRAKRV
190 200 210 220 230 240
LELSLEEARQ LGHNYIGSEH LLLGLLREGE GVAARVLENL GADPSNIRTQ VIRMVGENNE
250 260 270 280 290 300
VTANVGGGSS SNKMPTLEEY GTNLTKLAEE GKLDPVVGRQ PQIERVVQIL GRRTKNNPCL
310 320 330 340 350 360
IGEPGVGKTA IAEGLAQRIA SGDVPETIEG KKVITLDMGL LVAGTKYRGE FEERLKKLME
370 380 390 400 410 420
EIRQSDEIIL FIDEVHTLIG AGAAEGAIDA ANILKPALAR GELQCIGATT LDEYRKHIEK
430 440 450 460 470 480
DPALERRFQP VKVPEPTVDE TIQILKGLRE RYEIHHKLRY TDESLVAAAQ LSYQYISDRF
490 500 510 520 530 540
LPDKAIDLID EAGSRVRLRH AQVPEEAREL EKELRQITKE KNEAVRGQDF EKAGTLRDRE
550 560 570 580 590 600
IELRAEVSAI QAKGKEMSKA ESETGEEGPM VTESDIQHIV SSWTGIPVEK VSTDESDRLL
610 620 630 640 650 660
KMEETLHKRI IGQDEAVKAI SRAIRRARVG LKNPNRPIAS FIFSGPTGVG KSELAKALAA
670 680 690 700 710 720
YYFGSEEAMI RLDMSEFMER HTVSKLIGSP PGYVGYTEGG QLTEAVRRRP YTVVLFDEIE
730 740 750 760 770 780
KAHPDVFNMM LQILEDGRLT DSKGRTVDFK NTLLIMTSNV GSSVIEKGGR RIGFDLDYDE
790 800 810 820 830 840
KDSSYNRIKS LVTEELKQYF RPEFLNRLDE MIVFRQLTKL EVKEIADILL KEVFERLKKK
850 860 870 880 890 900
EIELQVTERF KERVVDEGYN PSYGARPLRR AIMRLLEDSM AEKMLAREIK EGDSVIVDVD
910 920
AEGNVTVLNG GSGTPTTSLE EQEDSLPVA