AiPD: Autoinhibited Protein Database

Gene name	CLPC2
Protein name	Chaperone protein ClpC2, chloroplastic
Names	ATP-dependent Clp protease ATP-binding subunit ClpC homolog 2, AtClpC, Casein lytic proteinase C2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G48870
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

224-307 (Predicted disordered autoinhibitory region) PR

224-307 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9SXJ7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH02472947	8	L>R	No	1000Genomes
tmp_3_18125971_A_T	13	F>Y	No	1000Genomes
ENSVATH06274698	33	K>M	No	1000Genomes
ENSVATH06274697	34	M>V	No	1000Genomes
ENSVATH06274696	39	A>S	No	1000Genomes
ENSVATH14404275	40	P>S	No	1000Genomes
ENSVATH06274695	44	I>N	No	1000Genomes
ENSVATH02472945	52	P>Q	No	1000Genomes
ENSVATH12649489	53	R>I	No	1000Genomes
tmp_3_18125825_A_T	62	L>I	No	1000Genomes
ENSVATH00409382	102	G>R	No	1000Genomes
tmp_3_18125558_T_C	151	I>V	No	1000Genomes
ENSVATH12649443	227	R>C	No	1000Genomes
ENSVATH12649442	239	N>T	No	1000Genomes
tmp_3_18125132_C_T	248	R>Q	No	1000Genomes
tmp_3_18124810_T_C	295	D>G	No	1000Genomes
tmp_3_18124753_C_T	314	R>K	No	1000Genomes
tmp_3_18124678_C_T	339	R>Q	No	1000Genomes
ENSVATH06274684	347	E>D	No	1000Genomes
ENSVATH02472935	353	T>M	No	1000Genomes
tmp_3_18124101_A_G	463	I>T	No	1000Genomes
ENSVATH14404265	522	A>T	No	1000Genomes
tmp_3_18123501_C_T	574	R>Q	No	1000Genomes
tmp_3_18123491_T_A	577	E>D	No	1000Genomes
tmp_3_18123457_C_T	589	G>R	No	1000Genomes
ENSVATH06274671	595	S>F	No	1000Genomes
ENSVATH06274666	729	R>H	No	1000Genomes
tmp_3_18122917_C_A	769	D>Y	No	1000Genomes
tmp_3_18122613_C_T	870	R>K	No	1000Genomes
tmp_3_18122595_A_G	876	V>A	No	1000Genomes
ENSVATH02472927	877	D>E	No	1000Genomes
tmp_3_18122403_G_T	940	A>D	No	1000Genomes
ENSVATH06274662	947	D>G	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Cadherin-like	49 - 137	IPR002126-1
domain	Cadherin-like	138 - 246	IPR002126-2
domain	Cadherin-like	246 - 351	IPR002126-3
domain	Cadherin-like	352 - 566	IPR002126-4
domain	Cadherin-like	583 - 687	IPR002126-5
domain	Cadherin, N-terminal	34 - 116	IPR013164
conserved_site	Cadherin conserved site	234 - 244	IPR020894-1
conserved_site	Cadherin conserved site	444 - 454	IPR020894-2
conserved_site	Cadherin conserved site	554 - 564	IPR020894-3
domain	Cadherin, C-terminal catenin-binding domain	815 - 936	IPR031904
domain	Cadherin, cytoplasmic C-terminal domain	692 - 775	IPR032455

		Description
EC Number
Subcellular Localization	Plastid, chloroplast stroma Plastid, chloroplast membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast envelope	The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
chloroplast membrane	Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope.
chloroplast stroma	The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plastid	Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
plastid stroma	The proteinaceous ground substance of plastids.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Name	Definition
chloroplast organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast.
protein import into chloroplast stroma	The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q60649	Clpb	Caseinolytic peptidase B protein homolog	Mus musculus (Mouse)	PR
Q9WTT2	Clpb	Caseinolytic peptidase B protein homolog	Rattus norvegicus (Rat)	PR
Q2QVG9	CLPC2	Chaperone protein ClpC2, chloroplastic	Oryza sativa subsp japonica (Rice)	PR
Q53LY0	CLPC3	Chaperone protein ClpC3, chloroplastic	Oryza sativa subsp japonica (Rice)	PR
Q7F9I1	CLPC1	Chaperone protein ClpC1, chloroplastic	Oryza sativa subsp japonica (Rice)	PR
P42730	CLPB1	Chaperone protein ClpB1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FI56	CLPC1	Chaperone protein ClpC1, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
P31541	CD4A	ATP-dependent Clp protease ATP-binding subunit ClpA homolog CD4A, chloroplastic	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	PR
P31542	CD4B	ATP-dependent Clp protease ATP-binding subunit ClpA homolog CD4B, chloroplastic	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	PR