Q9VH20

PR
Gene name
TAF1B
Protein name
TATA box-binding protein-associated factor RNA polymerase I subunit B
Names
TATA box-binding protein-associated factor 1B, TBP-associated factor 1B
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG6241
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VH20

Entry ID Method Resolution Chain Position Source
AF-Q9VH20-F1 Predicted AlphaFoldDB

No variants for Q9VH20

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VH20

No associated diseases with Q9VH20

No regional properties for Q9VH20

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9VH20

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
RNA polymerase I core factor complex A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.
RNA polymerase transcription factor SL1 complex A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
RNA polymerase I core promoter sequence-specific DNA binding Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.

2 GO annotations of biological process

Name Definition
nucleolar large rRNA transcription by RNA polymerase I The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.
RNA polymerase I preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P40992 RRN7 RNA polymerase I-specific transcription initiation factor RRN7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q1JQD6 TAF1B TATA box-binding protein-associated factor RNA polymerase I subunit B Bos taurus (Bovine) PR
P97358 Taf1b TATA box-binding protein-associated factor RNA polymerase I subunit B Mus musculus (Mouse) PR
D3ZYB7 Taf1b TATA box-binding protein-associated factor RNA polymerase I subunit B Rattus norvegicus (Rat) PR
O01914 F23H11.2 TATA box-binding protein-associated factor RNA polymerase I subunit B Caenorhabditis elegans PR
Q5XVF0 MEE12 TATA box-binding protein-associated factor RNA polymerase I subunit B Arabidopsis thaliana (Mouse-ear cress) PR
F1R3W0 taf1b TATA box-binding protein-associated factor RNA polymerase I subunit B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEEVLETMQL ENMHCDVCEG TTFQEREGFY YCVECGTQKD QIRAVDITAE DNFDDTAAGR
70 80 90 100 110 120
YTARTIRQKK DTEKEDEDDI TSWEFYNYVL RGFLQELLNM GAKPELKLMT LQVWAAYLDS
130 140 150 160 170 180
MEVAFSKSNK TGLPKLNVRA LPIDARIIYN HKTFKKGKKG KKSTLTGDPN DERAKFRLWN
190 200 210 220 230 240
RTKRNLDASG YRSHGGASES EGEQSLHLQW SMRARKSLKR HMPLKHLDKH SRDSKGSMSC
250 260 270 280 290 300
HSLRPRVKQL HNFDRNIYCL NIIKLYVVLG IALNMVEDDI QLSDLLRFID EEHLTKRCML
310 320 330 340 350 360
NYLPGNVAAK GKALLKDMEL SKMKDKVTNK LLRVNIACMS RFINLSEYQK PNLHSLAERY
370 380 390 400 410 420
ILELALPPRL LKYVNSLLDL HPPTFFNAMT VHPYPRYEAR TMAYILYAMK LLFGLDDLKE
430 440 450 460 470 480
RNISESAAKI NEKLLEVGGD EAPLLFVFTE WMEFVEMRKV IVSHYNQSFA RRFGVSTRTG
490 500 510 520 530 540
CQVDDILAKE WKEKEQGETF GWMQGSAAMK RQHENLTHII ETMLKDHFGE SSKESMEKEH
550 560 570 580 590 600
IEFQPSLTPA HSYFNRILLQ VSRSDGAKMK ITIPDHMKVD HSARNLDPFV LETTELSQYL
610 620 630 640 650 660
SQHGLKLRVE ELACQEDIQN VGIFRPLTII RGDGREYRAN TEIKTETWIS ELKRKEKRPD
670 680 690 700 710 720
FRFTQPTGTY GARYLKRITM RDARRVQLEI NNPFWDVTET PSFLLKLNDN EIPLDSLSSL
730 740 750 760 770 780
QTFEEGTMDP LNIPLDLPRR NLEKILNPEG SDRASDQVAS DINDEPPSPE TLLLQVSNFD
790 800 810 820 830 840
CWLLHGYMKR IRRHDKHELR QLFPCSFRWL LETCASTIGI VWEELYEELL IVEVMYHHSI
850 860 870
RDWSNHRNYL CIQHNTQEKD IRTLARTYKE LW