Q5XVF0
PR
Gene name |
MEE12 |
Protein name |
TATA box-binding protein-associated factor RNA polymerase I subunit B |
Names |
Central cell guidance protein, Protein MATERNAL EFFECT EMBRYO ARREST 12, TATA box-binding protein-associated factor 1B, TBP-associated factor 1B |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G02955 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5XVF0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5XVF0-F1 | Predicted | AlphaFoldDB |
85 variants for Q5XVF0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00203341 | 10 | A>T | No | 1000Genomes | |
| tmp_2_859724_G_T | 45 | G>C | No | 1000Genomes | |
| ENSVATH01621692 | 64 | P>T | No | 1000Genomes | |
| tmp_2_859823_C_G | 78 | R>G | No | 1000Genomes | |
| tmp_2_859842_C_A | 84 | S>Y | No | 1000Genomes | |
| ENSVATH01621693 | 91 | G>E | No | 1000Genomes | |
| ENSVATH05224616 | 92 | N>I | No | 1000Genomes | |
| ENSVATH01621694 | 93 | K>N | No | 1000Genomes | |
| ENSVATH05224618 | 96 | P>S | No | 1000Genomes | |
| ENSVATH05224619 | 100 | K>T | No | 1000Genomes | |
| ENSVATH00203343 | 104 | D>E | No | 1000Genomes | |
| ENSVATH13897788 | 106 | Y>C | No | 1000Genomes | |
| ENSVATH05224620 | 118 | A>G | No | 1000Genomes | |
| ENSVATH01621697 | 136 | V>I | No | 1000Genomes | |
| tmp_2_860004_C_G | 138 | A>G | No | 1000Genomes | |
| tmp_2_860052_T_A | 154 | F>Y | No | 1000Genomes | |
| ENSVATH05224622 | 157 | T>P | No | 1000Genomes | |
| tmp_2_860074_T_G | 161 | I>M | No | 1000Genomes | |
| ENSVATH05224623 | 171 | Y>F | No | 1000Genomes | |
| ENSVATH05224624 | 174 | L>F | No | 1000Genomes | |
| ENSVATH00203345 | 184 | N>S | No | 1000Genomes | |
| ENSVATH05224625 | 185 | N>S | No | 1000Genomes | |
| tmp_2_860169_A_T | 193 | Q>L | No | 1000Genomes | |
| ENSVATH01621702 | 195 | E>V | No | 1000Genomes | |
| ENSVATH10749039 | 198 | E>Q | No | 1000Genomes | |
| ENSVATH05224632 | 227 | I>V | No | 1000Genomes | |
| ENSVATH05224633 | 232 | M>I | No | 1000Genomes | |
| tmp_2_860463_G_C | 263 | E>Q | No | 1000Genomes | |
| tmp_2_860508_C_A | 278 | Q>K | No | 1000Genomes | |
| tmp_2_860532_T_A | 286 | C>S | No | 1000Genomes | |
| tmp_2_860538_G_T | 288 | V>L | No | 1000Genomes | |
| ENSVATH00203349 | 290 | V>A | No | 1000Genomes | |
| tmp_2_860574_A_T | 300 | I>F | No | 1000Genomes | |
| tmp_2_860598_C_G | 308 | R>G | No | 1000Genomes | |
| ENSVATH00203352 | 315 | T>I | No | 1000Genomes | |
| tmp_2_860632_C_A | 319 | P>H | No | 1000Genomes | |
| ENSVATH05224636 | 321 | P>L | No | 1000Genomes | |
| ENSVATH13897789 | 324 | N>K | No | 1000Genomes | |
| ENSVATH13897790 | 347 | A>V | No | 1000Genomes | |
| tmp_2_860794_G_T | 373 | C>F | No | 1000Genomes | |
| ENSVATH01621712 | 379 | I>M | No | 1000Genomes | |
| ENSVATH01621713 | 385 | L>F | No | 1000Genomes | |
| tmp_2_860878_T_C | 401 | V>A | No | 1000Genomes | |
| ENSVATH05224638 | 404 | S>G | No | 1000Genomes | |
| ENSVATH01621715 | 405 | D>E | No | 1000Genomes | |
| ENSVATH01621716 | 407 | D>V | No | 1000Genomes | |
| ENSVATH05224639 | 408 | S>L | No | 1000Genomes | |
| ENSVATH05224640 | 409 | E>K | No | 1000Genomes | |
| ENSVATH05224641 | 410 | T>I | No | 1000Genomes | |
| ENSVATH05224642 | 411 | N>T | No | 1000Genomes | |
| ENSVATH00203354 | 413 | G>S | No | 1000Genomes | |
| ENSVATH05224644 | 415 | A>P | No | 1000Genomes | |
| ENSVATH05224645 | 417 | K>E | No | 1000Genomes | |
| tmp_2_860929_C_A | 418 | A>E | No | 1000Genomes | |
| ENSVATH00203355 | 418 | A>T | No | 1000Genomes | |
| tmp_2_860942_T_A | 422 | D>E | No | 1000Genomes | |
| ENSVATH05224646 | 424 | Q>E | No | 1000Genomes | |
| ENSVATH01621718 | 424 | Q>L | No | 1000Genomes | |
| ENSVATH10749040 | 433 | K>N | No | 1000Genomes | |
| tmp_2_861131_C_G | 485 | D>E | No | 1000Genomes | |
| tmp_2_861134_G_T | 486 | E>D | No | 1000Genomes | |
| tmp_2_861238_A_T | 489 | E>D | No | 1000Genomes | |
| ENSVATH01621727 | 489 | E>K | No | 1000Genomes | |
| ENSVATH00203357 | 490 | C>R | No | 1000Genomes | |
| tmp_2_861249_A_G | 493 | K>R | No | 1000Genomes | |
| ENSVATH05224652 | 497 | D>E | No | 1000Genomes | |
| ENSVATH01621729 | 498 | W>R | No | 1000Genomes | |
| ENSVATH01621730 | 499 | D>E | No | 1000Genomes | |
| ENSVATH05224653 | 501 | D>N | No | 1000Genomes | |
| ENSVATH00203358 | 510 | Y>D | No | 1000Genomes | |
| tmp_2_861302_G_C | 511 | D>H | No | 1000Genomes | |
| tmp_2_861350_A_G | 527 | R>G | No | 1000Genomes | |
| ENSVATH05224655 | 533 | I>K | No | 1000Genomes | |
| ENSVATH05224656 | 534 | G>D | No | 1000Genomes | |
| ENSVATH05224657 | 538 | S>F | No | 1000Genomes | |
| ENSVATH05224658 | 545 | S>T | No | 1000Genomes | |
| ENSVATH01621732 | 554 | I>R | No | 1000Genomes | |
| ENSVATH05224659 | 561 | T>R | No | 1000Genomes | |
| ENSVATH00203360 | 561 | T>S | No | 1000Genomes | |
| ENSVATH05224660 | 565 | D>E | No | 1000Genomes | |
| tmp_2_861561_C_T | 597 | A>V | No | 1000Genomes | |
| ENSVATH10749044 | 631 | L>M | No | 1000Genomes | |
| ENSVATH13897792 | 641 | V>I | No | 1000Genomes | |
| ENSVATH05224663 | 661 | G>R | No | 1000Genomes | |
| tmp_2_861759_A_G | 663 | D>G | No | 1000Genomes |
No associated diseases with Q5XVF0
1 regional properties for Q5XVF0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Transcription initiation factor Rrn7, Zinc-finger | 1 - 29 | IPR021752 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| RNA polymerase I core factor complex | A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p. |
| RNA polymerase transcription factor SL1 complex | A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| RNA polymerase I core promoter sequence-specific DNA binding | Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| embryo development ending in seed dormancy | The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. |
| nucleolar large rRNA transcription by RNA polymerase I | The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I. |
| RNA polymerase I preinitiation complex assembly | The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40992 | RRN7 | RNA polymerase I-specific transcription initiation factor RRN7 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q1JQD6 | TAF1B | TATA box-binding protein-associated factor RNA polymerase I subunit B | Bos taurus (Bovine) | PR |
| Q9VH20 | TAF1B | TATA box-binding protein-associated factor RNA polymerase I subunit B | Drosophila melanogaster (Fruit fly) | PR |
| P97358 | Taf1b | TATA box-binding protein-associated factor RNA polymerase I subunit B | Mus musculus (Mouse) | PR |
| D3ZYB7 | Taf1b | TATA box-binding protein-associated factor RNA polymerase I subunit B | Rattus norvegicus (Rat) | PR |
| O01914 | F23H11.2 | TATA box-binding protein-associated factor RNA polymerase I subunit B | Caenorhabditis elegans | PR |
| F1R3W0 | taf1b | TATA box-binding protein-associated factor RNA polymerase I subunit B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MICTECENDA | FDEEDDGYYY | CQRCGVQVEN | LIQTGVDDGD | LIGEGGGTQG | ALYNPKHRRT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EPQPITPSQP | RFTDDTSRYS | QFKSQFESEN | GNKELPREVK | RAPDSYVDKE | PTEPVDFAAE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TLSYENYYDE | ARDRYVKAFL | MMITYQCDAL | VDKFNVTPLI | IGLVGPISLR | YVALSGVYHK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DWANNAIRDS | EHQSEDGEVK | DAKRLKRHKA | EPRNIDGKRA | VTIWFGILKK | TMPLSSSLVI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SFLACHQAGA | PVLPTDIVRW | AREGKLPYLS | CFLDIREQMG | ERSAACPVKV | SIMARPFQVI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SAQMLEARAS | VIADTIGLPL | PPVNFYGIAS | NYIKQLSIPE | DKILDLARLI | QNWSLPPELY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSTNEQKLPS | RVCVMSILIV | AIRMLYNING | LGVWERSLGF | VNASDGDSET | NSGTAEKATE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FDTQELLKNL | EAKYHEVAAE | TLESEKDLVS | YLSLGKNEFF | AGLEEDSPDD | TYRIVDNLWN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GYPKDEDIEC | LPKRGRDWDD | DVSLNQLSLY | DSRFSDGNNP | CSSSSRRNES | VSIGLDLSSS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EHRESSSPEK | LKEIAIKRLI | TDMGDDLFCY | IPPRVKVKRL | DYLQYVRKKE | DGALIYAAHA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DYYILLRVCA | KVAEIDVRNM | HRGVLSFERR | LAWIEKRIDQ | VLHLTRPLMT | CKHCCDDGNI |
| GEDQDD |