D3ZYB7

PR
Gene name
Taf1b
Protein name
TATA box-binding protein-associated factor RNA polymerase I subunit B
Names
RNA polymerase I-specific TBP-associated factor 63 kDa, TAFI63, TATA box-binding protein-associated factor 1B, TBP-associated factor 1B, Transcription initiation factor SL1/TIF-IB subunit B
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:690450
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

118-214 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for D3ZYB7

Entry ID Method Resolution Chain Position Source
AF-D3ZYB7-F1 Predicted AlphaFoldDB

1 variants for D3ZYB7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3320774448 504 I>V No EVA

No associated diseases with D3ZYB7

2 regional properties for D3ZYB7

Type Name Position InterPro Accession
domain Bromodomain associated domain 1 - 42 IPR006565
domain Transcription factor TFIID, subunit 8, C-terminal 81 - 134 IPR019473

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
RNA polymerase I core factor complex A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.
RNA polymerase transcription factor SL1 complex A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
RNA polymerase I core promoter sequence-specific DNA binding Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.

2 GO annotations of biological process

Name Definition
nucleolar large rRNA transcription by RNA polymerase I The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.
RNA polymerase I preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P40992 RRN7 RNA polymerase I-specific transcription initiation factor RRN7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q1JQD6 TAF1B TATA box-binding protein-associated factor RNA polymerase I subunit B Bos taurus (Bovine) PR
Q9VH20 TAF1B TATA box-binding protein-associated factor RNA polymerase I subunit B Drosophila melanogaster (Fruit fly) PR
P97358 Taf1b TATA box-binding protein-associated factor RNA polymerase I subunit B Mus musculus (Mouse) PR
O01914 F23H11.2 TATA box-binding protein-associated factor RNA polymerase I subunit B Caenorhabditis elegans PR
Q5XVF0 MEE12 TATA box-binding protein-associated factor RNA polymerase I subunit B Arabidopsis thaliana (Mouse-ear cress) PR
F1R3W0 taf1b TATA box-binding protein-associated factor RNA polymerase I subunit B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDVEQMKAFT DRCSQCAAVS WGLTDEGKYY CTSCHNVTDR SEEVVSTAVI PNTKINSISR
70 80 90 100 110 120
GLRQRSKHEK GWDWYVCEGF QCILYHQAEA LETLGVSPEL KNEVLHSFWK RYLQKSKQAY
130 140 150 160 170 180
CKNPVRTSGR KAKVLEDNLQ SSDWGSDFEL LSDTTCPPES GAEFQSDSQT PKPFPATKRS
190 200 210 220 230 240
SKSASVCSGS VDGVEYSERK EKGLLKMTVP RTLALCYLSL LWQRETITLS DLLRFVEEDR
250 260 270 280 290 300
IPYINAFKVF PEEMKVYGRD KGIFAVESWP DYEDIYKNMI EVAVFLDLPR FPDITEDCYL
310 320 330 340 350 360
HPNTLCMKYL LEVNLPEEMY TLTCQVVKLT GIGEVDFLTF DPIAKMTRTV KHDVQAVAVI
370 380 390 400 410 420
VLVLKLLFLL DDKLEWSYSD LAEAYNEGHK EETPQFDFRK WYQVMKKTFD EKRRKWEEAR
430 440 450 460 470 480
AKYVWKTKRP LYRSHIDKSV AYKRREMVEN LQKQFSALIG SAPEVERQAP SSFQLNWTGE
490 500 510 520 530 540
DTGSPCFHGH SLQGLLISKG QALITKNSLY WLSTHKFCKS YCKHVTTYEE SNFSLSYQFI
550 560 570 580
LNIFSFLLRI KTSALHEEVS LLEKKLFEKK YNESKRSSRS KKVRRH